期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 42, 期 3, 页码 256-263出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2007.11.006
关键词
hydrogel; konjac glucomannan; controlled release; DNA delivery
In this study, hydrogels for DNA-controlled release was prepared with konjac glucomannan (KGM), a water-soluble non-ionic polysaccharide, by means of deacetylated reaction and physically cross-linking method under mild conditions. The properties of the KGM hydrogels were analyzed by FTIR spectra and scanning electron microscopy (SEM). The integrality of the released DNA was investigated by circular dichroism (CD). The DNA release kinetics was performed using the DNA-loaded KGM gels in buffer solutions of pH 7.4 at 37 +/- 0.5 degrees C. Peppas model and Higuchi model were used to analysis the DNA release mechanism; the data indicated that the DNA release can be controlled by changing the preparation conditions and the structure parameters of the gels. This study suggested that the KGM hydrogels have a potential use for advanced controlled release. (C) 2007 Elsevier B.V. All rights reserved.
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