期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 54, 期 -, 页码 78-82出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.07.002
关键词
Chemokine receptor; Cancer; Metastasis formation; Cell migration; Lymph node homing
资金
- Swiss National Science Foundation [SNF 31003A-143841/1]
- Thurguische Krebsliga
- Novartis Foundation for medial-biological research
- Thurgauische Stiftung fur Wissenschaft und Forschung
- Swiss State Secretariat for Education and Research
- Research Training Group [1331]
The CC-chemokine receptor 7 (CCR7) coordinates the migration of cancer cells as well as immune cells towards lymphatic organs where its two ligands CCL19 and CCL21 are constitutively expressed. Here we provide a topological model of CCR7, which belongs to the class A of G-protein coupled, seven-transmembrane spanning receptors, and describe how CCR7 expression is regulated. We focus on its role in cancer cell migration and metastasis formation and discuss how cancer cells can utilize CCR7 or its ligands to escape from immune surveillance. (C) 2014 Elsevier Ltd. All rights reserved.
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