Article
Biochemistry & Molecular Biology
Tingting Peng, Yinyin Xie, Hanqing Sheng, Cui Wang, Yajun Lian, Nanchang Xie
Summary: Mitochondrial quality control mechanisms ensure the stability and function of mitochondria. Mitochondrial-derived vesicles play a crucial role in defending against oxidative stress. Abnormal MDVs can disrupt metabolite clearance and immune response, leading to pathological conditions.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Paria Ali Pour, Sina Hosseinian, Arash Kheradvar
Summary: Mitochondrial transplantation is a novel cellular biotherapy that shows promise in alleviating mitochondrial damage and dysfunction, and potentially improving outcomes of various diseases related to mitochondrial function. By transferring mitochondria from different sources into cells, it has been shown to positively modulate bioenergetics and improve disease outcomes.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Man Liu, Samuel C. Dudley
Summary: Magnesium is essential for cell functions and its deficiency (HypoMg) can lead to cardiovascular diseases. Magnesium supplementation and TRPM7 kinase inhibition may have therapeutic effects for HypoMg and other diseases.
Review
Biochemistry & Molecular Biology
Marco D'Amato, Francesca Morra, Ivano Di Meo, Valeria Tiranti
Summary: Mitochondrial diseases are genetic conditions caused by mutations in nuclear or mitochondrial DNA. Existing therapies are insufficient for treating the wide range of mtDNA mutations. Mitochondrial transplantation offers a potential solution by transferring healthy mitochondria to dysfunctional cells or tissues. This review explores the mechanisms and methods of intercellular mitochondrial transfer and discusses its potential therapeutic applications. Mitochondrial transplantation could induce a shift in heteroplasmy and potentially attenuate or prevent pathological phenotypes. However, further research is needed before its widespread use in mitochondrial medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Anezka Vodickova, Shon A. Koren, Andrew P. Wojtovich
Summary: Mitochondria are vital for neuronal survival and their dysfunction is associated with neurodegenerative diseases. Different types of mitochondrial dysfunction are linked to distinct neuropathologies. Understanding the relationship between mitochondrial changes and neuropathology will lead to new therapeutic strategies.
Review
Pharmacology & Pharmacy
Walter H. Moos, Douglas V. Faller, Ioannis P. Glavas, David N. Harpp, Natalia Kamperi, Iphigenia Kanara, Krishna Kodukula, Anastasios N. Mavrakis, Julie Pernokas, Mark Pernokas, Carl A. Pinkert, Whitney R. Powers, Kosta Steliou, Constantin Tamvakopoulos, Demetrios G. Vavvas, Robert J. Zamboni, Konstantina Sampani
Summary: This article traces the connections between biochemical pathways, pathogenesis, and metabolic diseases, emphasizing the crucial role of mitochondria in metabolic disorders and the genetic, metabolic, and mitochondrial factors in various diseases such as diabetes and heart failure.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Elad Jacoby, Moriya Ben Yakir-Blumkin, Shiri Blumenfeld-Kan, Yehuda Brody, Amilia Meir, Naomi Melamed-Book, Tina Napso, Gat Pozner, Esraa Saadi, Ayelet Shabtay-Orbach, Natalie Yivgi-Ohana, Noa Sher, Amos Toren
Summary: The study introduces a novel approach called Mitochondrial Augmentation Therapy (MAT) that can ex vivo augment hematopoietic stem and progenitor cells (HSPCs) with normal exogenous mitochondria, improving their mitochondrial content and oxygen consumption, and showing potential disease-modifying therapy effects in animal models.
NPJ REGENERATIVE MEDICINE
(2021)
Editorial Material
Multidisciplinary Sciences
Anna Nowogrodzki
Summary: The United States has made progress in reducing child mortality, but adults have been neglected in this regard.
Article
Behavioral Sciences
Muneeb U. Rehman, Nouroz Sehar, Nawab John Dar, Andleeb Khan, Azher Arafah, Summya Rashid, Shahzada Mudasir Rashid, Majid Ahmad Ganaie
Summary: Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease (PD), and Huntington disease (HD) pose significant social and economic challenges due to their high prevalence and poor treatment outcomes. The lack of clarity regarding the underlying mechanisms of these diseases hampers drug development efforts. However, shared pathways such as mitochondrial dysfunction, oxidative stress, and inflammation provide potential targets for therapeutic interventions to slow down or stop disease progression. This review aims to highlight recent advancements and findings in understanding shared mechanisms, providing insights for the development of more effective pharmacological interventions to reduce the onset or severity of NDs.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Medicine, Research & Experimental
Mingchu Sun, Wenhua Jiang, Nan Mu, Zihui Zhang, Lu Yu, Heng Ma
Summary: Cardiovascular disease (CVD) is the leading cause of noncommunicable disease-related death worldwide, and effective therapeutic strategies against CVD are urgently needed. Mitochondria dysfunction involves in the onset and development of CVD. Nowadays, mitochondrial transplantation, an alternative treatment aimed at increasing mitochondrial number and improving mitochondrial function, has been emerged with great therapeutic potential. Substantial evidence indicates that mitochondrial transplantation improves cardiac function and outcomes in patients with CVD. Therefore, mitochondrial transplantation has profound implications in the prevention and treatment of CVD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
James M. Porter, Lea Guerassimoff, Francisco Rafael Castiello, Andre Charette, Maryam Tabrizian
Summary: Islet transplantation is a long-term cure for Type 1 Diabetes (T1D), and the study of INGAP-P variants shows potential for improving the insulin output of transplanted cells. A proof-of-concept study investigated novel molecular variants of INGAP-P and identified four peptide variants with statistically significant enhancements in insulin secretion and gene expression. This study highlights the potential of customized peptides for type 1 diabetes therapy and provides a foundation for future research.
Article
Cell Biology
Bani Bandana Ganguly, Nitin N. Kadam
Summary: Genome-wide deregulation leads to mitochondrial dysfunction in individuals with Down syndrome, resulting in oxidative stress, increased production of reactive oxygen species (ROS), and cell death. The impairment in mitochondrial network is closely linked to cellular and systemic pathology, causing various clinical manifestations such as intellectual disability, early aging, neurodegeneration, and Alzheimer's disease-related dementia. Therapeutic challenges involve improving mitochondrial defects using natural compounds like polyphenols, antioxidants, and flavonoids, which have shown promising outcomes in animal models and humans with Down syndrome.
Editorial Material
Multidisciplinary Sciences
Jyoti Madhusoodanan
Summary: Genomic jigsaw puzzles and timely vaccinations are among the notable highlights in studies about hepatitis B.
Editorial Material
Multidisciplinary Sciences
Liam Drew
Summary: The global effort to eliminate the disease primarily relies on blocking the most common mode of viral infection.
Editorial Material
Multidisciplinary Sciences
Bianca Nogrady
Summary: Pain is the main symptom in sickle-cell disease, but it is not well understood, and people with this disease face both medical and socioeconomic challenges when seeking effective relief.
Article
Cell & Tissue Engineering
Po-Jui Huang, Chi-Chung Kuo, Hsiu-Chin Lee, Ching-I Shen, Fu-Chou Cheng, Shih-Fang Wu, Jui-Chih Chang, Hung-Chuan Pan, Shinn-Zong Lin, Chin-San Liu, Hong-Lin Su
CELL TRANSPLANTATION
(2016)
Article
Medical Laboratory Technology
Jui-Chih Chang, Shey-Lin Wu, Ko-Hung Liu, Ya-Hui Chen, Chieh-Sen Chuang, Fu-Chou Cheng, Hong-Lin Su, Yau-Huei Wei, Shou-Jen Kuo, Chin-San Liu
TRANSLATIONAL RESEARCH
(2016)
Article
Medicine, Research & Experimental
Chieh-Sen Chuang, Jui-Chih Chang, Fu-Chou Cheng, Ko-Hung Liu, Hong-Lin Su, Chin-San Liu
Article
Pediatrics
Chien-Chou Hsiao, Jui-Chih Chang, Lon-Yen Tsao, Rei-Cheng Yang, Hsiao-Meng Chen, Cheng-Han Lee, Ching-Yuang Lin, Yi-Giien Tsai
PEDIATRICS AND NEONATOLOGY
(2017)
Article
Neurosciences
Shin-Wu Liu, Jui-Chih Chang, Sheng-Fei Chuang, Ko-Hung Liu, Wen-Ling Cheng, Hui-Ju Chang, Huei-Shin Chang, Ta-Tsung Lin, Ching-Liang Hsieh, Wei-Yong Lin, Mingli Hsieh, Shou-Jen Kuo, Chin-San Liu
Article
Biochemistry & Molecular Biology
Yu-Ling Wu, Jui-Chih Chang, Wei-Yong Lin, Chien-Chun Li, Mingli Hsieh, Haw-Wen Cheng, Tsu-Shing Wang, Wen-Tzu Wu, Chin-San Liu, Kai-Li Liu
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Multidisciplinary Sciences
Jui-Chih Chang, Fredrik Hoel, Ko-Hung Liu, Yau-Huei Wei, Fu-Chou Cheng, Shou-Jen Kuo, Karl Johan Tronstad, Chin-San Liu
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Yu-Ling Wu, Jui-Chih Chang, Wei-Yong Lin, Chien-Chun Li, Mingli Hsieh, Haw-Wen Chen, Tsu-Shing Wang, Chin-San Liu, Kai-Li Liu
SCIENTIFIC REPORTS
(2017)
Article
Medicine, Research & Experimental
Chieh-Sen Chuang, Jui-Chih Chang, Bing-Wen Soong, Sheng-Fei Chuang, Ta-Tsung Lin, Wen-Ling Cheng, Harry T. Orr, Chin-San Liu
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Sheylin Wu, Kohung Liu, Wenling Cheng, Shihli Su, Yongshiou Lin, Tatsung Lin, Yushan Cheng, Juichih Chang, Yuling Wu, Chinsan Liu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biotechnology & Applied Microbiology
Jui-Chih Chang, Huei-Shin Chang, Yao-Chung Wu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ju Chang, Shou-Tung Chen, Chin-San Liu
ONCOTARGETS AND THERAPY
(2020)
Article
Nutrition & Dietetics
Yu-Ling Wu, Jui-Chih Chang, Hai-Lun Sun, Wen-Ling Cheng, Yu-Pei Yen, Yong-Shiou Lin, Yi-Chun Chao, Ko-Hung Liu, Ching-Shan Huang, Kai-Li Liu, Chin-San Liu
Summary: This study demonstrated the protective effect of Coenzyme Q10 (CoQ10) in spinocerebellar ataxia type 3 (SCA3) treatment. Results showed that CoQ10 supplementation significantly improved locomotion in mice and restored the structure of the cerebellar layers. Moreover, CoQ10 facilitated the clearance of mutant ataxin-3 protein through autophagy and restored the expression of antioxidant enzymes. Additionally, CoQ10 treatment prevented muscle weight loss and muscle atrophy in diseased mice.
Article
Biochemical Research Methods
Ying-Ting Lin, Sung-Tzu Chen, Jui-Chih Chang, Ren-Jie Teoh, Chin-San Liu, Gou-Jen Wang
Article
Materials Science, Biomaterials
Chien-Hui Su, Jyun-Wei Chen, Li-Da Chen, Jui-Chih Chang, Chin-San Liu, Cheng-Chung Chang, Gou-Jen Wang
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Engineering, Multidisciplinary
Yu-Han Hsiao, Ching-Wen Li, Jui-Chih Chang, Sung-Tzu Chen, Chin-San Liu, Gou-Jen Wang
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
