Article
Multidisciplinary Sciences
Maria A. Duque-Correa, David Goulding, Faye H. Rodgers, Claire Cormie, Kate Rawlinson, J. Andrew Gillis, Allison J. Bancroft, Hayley M. Bennett, Magda Lotkowska, Adam J. Reid, Anneliese Speak, Paul Scott, Nicholas Redshaw, Catherine McCarthy, Cordelia Brandt, Catherine Sharpe, Caroline Ridley, Judit Gali Moya, Claudia M. Carneiro, Tobias Starborg, Kelly S. Hayes, Nancy Holroyd, Mandy Sanders, David J. Thornton, Richard K. Grencis, Matthew Berriman
Summary: Whipworms are large parasites causing chronic disease in humans and other mammals. Researchers have discovered how the larvae invade host epithelial cells, establishing infection by degrading mucus layers and creating tunnels. This interaction between the whipworm and the host triggers an immune response and tissue repair.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Sameer Tiwari, Sharmin Begum, France Moreau, Hayley Gorman, Kris Chadee
Summary: This study reveals that autophagy plays a crucial role in regulating cellular homeostasis in goblet cells during high mucin biosynthesis. Additionally, IL-22 treatment can correct misfolded MUC2 proteins and alleviate the autophagy process in cells.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Xueqin Sang, Qingyu Wang, Yueyan Ning, Huihui Wang, Rui Zhang, Yixuan Li, Bing Fang, Cong Lv, Yan Zhang, Xiaoyu Wang, Fazheng Ren
Summary: During aging, the protective function of mucus barrier, especially in the colon, decreases, leading to an increased incidence of colon-related diseases. This study investigated the changes in the colonic mucus barrier with aging and found that the aged colon exhibited dysfunction and altered properties in the mucus layer. The expression of goblet cells, glycosyltransferase, and enzymes involved in mucin core structure formation and glycan modification were affected by aging. The results indicate the importance of the goblet cells/glycosyltransferase/O-glycan axis in maintaining the physicochemical properties of colonic mucus and the stability of the intestinal environment.
Article
Immunology
Pia M. Vornewald, Ruth Forman, Rouan Yao, Naveen Parmar, Havard T. Lindholm, Lilith S. K. Lee, Mara Martin-Alonso, Kathryn J. Else, Menno J. Oudhoff
Summary: This study investigates the role of MMP17 in intestinal homeostasis and immune response to infection. The results show that MMP17-deficient mice do not have altered resistance during bacterial infection, but show increased resistance during helminth infection. Mechanistically, MMP17 regulates goblet cell maturation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yada Duangnumsawang, Juergen Zentek, Farshad Goodarzi Boroojeni
Summary: Intestinal mucus is critical for protecting epithelial surfaces, supporting commensal bacteria, maintaining digestion, and facilitating nutrient transport. Goblet cell development and mucus production in poultry are influenced by age and dietary factors, affecting the mucosal barrier's protective mechanisms. Research on the impact of age and dietary factors on mucosal integrity in poultry needs further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Tingfeng Qin, Jie Yang, Dayin Huang, Zhijun Zhang, Yanling Huang, Hui Chen, Geyang Xu
Summary: DOCK4 plays a critical role in goblet cell differentiation and MUC2 production in the intestine, with its deletion leading to disordered intestinal epithelium, decreased goblet cells, and altered expression of related differentiation factors.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Seongho Ma, Jiah Yeom, Young-Hee Lim
Summary: This study investigates the mechanism of MUC2 expression in intestinal goblet cells stimulated by the short-chain fatty acid propionate. The study finds that propionate metabolism via a beta-oxidation-like pathway leads to hypoxia, which activates HIF-2 alpha and stimulates MUC2 production. These findings suggest that propionate-induced selective HIF-2 alpha stimulation plays a role in intestinal mucosal defense.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hassan Melhem, Daniel Regan-Komito, Jan Hendrik Niess
Summary: Maintaining intestinal health requires a clear segregation between epithelial cells and luminal microbes, which is achieved by the intestinal mucus layer produced by goblet cells. Disruption of goblet cells and mucus layer dysfunction are closely related to the pathogenesis of inflammatory bowel disease (IBD), but the molecular mechanisms regulating goblet cell physiology and the mucus layer remain unclear. Further research is needed to understand how internal (host) and external (diets and bacteria) factors modulate the mucus layer and its impact on the onset of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Varsha Singh, Kelli Johnson, Jianyi Yin, Sun Lee, Ruxian Lin, Huimin Yu, Julie In, Jennifer Foulke-Abel, Nicholas C. Zachos, Mark Donowitz, Yan Rong
Summary: One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer, which is partly due to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contributes to the reduced mucus layer. This study found that chronic inflammation in UC causes long-term changes in GCs, leading to abnormal mucus secretion, which may contribute to the recurrence of UC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Alejandro Bravo Iniguez, Qiyu Tian, Min Du, Mei-Jun Zhu
Summary: The metabolite alpha-ketoglutarate (aKG) shows potential for ameliorating colitis by reducing harmful metabolites and promoting goblet cell differentiation, resulting in a stronger mucus layer.
Article
Multidisciplinary Sciences
Daniel Song, Ethan Iverson, Logan Kaler, Allison Boboltz, Margaret A. Scull, Gregg A. Duncan
Summary: This study investigates the roles of mucins MUC5B and MUC5AC in airway clearance and demonstrates their individual contributions to mucociliary transport and coordination.
Review
Oncology
Kieran Palmer, Scott Weerasuriya, Kandiah Chandrakumaran, Brian Rous, Benjamin E. White, Sangeeta Paisey, Rajaventhan Srirajaskanthan, John K. Ramage
Summary: Goblet cell adenocarcinoma of the appendix is a rare and aggressive tumor with increasing incidence, and further research is needed to establish optimal management.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yaxin Liu, Zihan Yu, Lanping Zhu, Shuang Ma, Yang Luo, Huixi Liang, Qinlingfei Liu, Jihua Chen, Sitan Guli, Xin Chen
Summary: The gut mucosa is protected by mucus, with Mucin2 (MUC2) being the main component. Research on MUC2 has revealed its importance beyond maintaining the mucus barrier, with dysregulated MUC2 production being associated with various gut diseases. This review provides a comprehensive understanding of MUC2, including its structure, significance, and regulatory mechanisms. The aim is to offer guidance for future research and potential therapeutic approaches for MUC2-related diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Beatriz Lopez-Cauce, Andres Urquia, Luis Menchen, Kohei Homma, Francisco Bolas-Fernandez, Juan J. Garcia-Rodriguez, Marta Puerto
Summary: This study evaluated the immunomodulatory effect of AHCC(R) in a murine model of Trichinella spiralis infection. The results showed that AHCC(R) could modulate the expression levels of Th1 and Th2 cytokines, reduce tissue damage, decrease the number of adult Trichinella spiralis, and promote parasite expulsion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Henry Danahay, Sarah Lilley, Kathryn Adley, Holly Charlton, Roy Fox, Martin Gosling
Summary: Niclosamide and benzbromarone have been considered as clinical candidates for the treatment of airway diseases due to their activity as inhibitors of the calcium activated chloride channel TMEM16A. However, this study reveals that both compounds have off-target effects and also questions the classification of niclosamide as a TMEM16A blocker. The study further suggests a potential role of TMEM16A in the regulation of epithelial ion transport and mucus secretion in the airway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun
Summary: The study demonstrates that thioguanine nucleotide can inhibit Wnt/beta-catenin signaling via Rac1 to prevent carcinogenesis in colonic epithelial cells, independently of inflammation and autophagy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Md Ashik Ullah, Sonja Rittchen, Jia Li, Sumaira Z. Hasnain, Simon Phipps
Summary: In neonatal mice infected with PVM, treatment with the DP1 agonist BW245c increased IFN-lambda production and reduced viral load in the first week of infection. However, in the second week, BW245c treatment unexpectedly led to higher mortality, possibly due to viral spread, increased cellular infiltration, and elevated production of pro-inflammatory cytokines like TNF-alpha. Administering an anti-TNF-alpha antibody alleviated these effects, suggesting that pharmacological activation of DP1 receptor can boost antiviral immunity but may have detrimental consequences.
MUCOSAL IMMUNOLOGY
(2021)
Article
Pediatrics
Manisha Ramphul, Kathryn G. Welsh, Richard D. May, Michael A. Ghebre, Laura Rapley, Emma Suzanne Cohen, Athula Herath, William Monteiro, Karine Rousseau, David J. Thornton, Christopher E. Brightling, Erol A. Gaillard
Summary: The study found that sputum mediator profiles consistent with bacterial and viral respiratory infections, as well as T2 inflammation markers, co-exist in children with acute severe asthma attacks.
Article
Critical Care Medicine
Rhiannon B. Werder, Md Ashik Ullah, Muhammed Mahfuzur Rahman, Jennifer Simpson, Jason P. Lynch, Natasha Collinson, Sonja Rittchen, Ridwan B. Rashid, Md Al Amin Sikder, Herlina Y. Handoko, Bodie F. Curren, Ismail Sebina, Gunter Hartel, Alec Bissell, Sylvia Ngo, Tejasri Yarlagadda, Sumaira Z. Hasnain, Wenying Lu, Sukhwinder S. Sohal, Megan Martin, Simon Bowler, Lucy D. Burr, Laurent O. Martinez, Bernard Robaye, Kirsten Spann, Manuel A. R. Ferreira, Simon Phipps
Summary: The study discovers P2Y(13)-R as a novel regulator of the nuclear alarmins IL-33 and HMGB1, and demonstrates that targeting this GPCR through genetic deletion or treatment with small-molecule antagonists protects against the onset and exacerbations of asthma.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yuxue Cao, Prarthana Rewatkar, Ran Wang, Sumaira Z. Hasnain, Amirali Popat, Tushar Kumeria
Summary: Biologics, or macromolecular therapeutics of biological origin, have emerged as a rapidly growing class of drugs for the treatment of chronic and acute conditions. However, their administration via the parenteral route results in high cost, low patient compliance, and systemic toxicity, prompting researchers to focus on developing carriers for oral delivery. This review examines the challenges of oral biologics delivery, discusses conventional formulation strategies and their limitations, and explores the progress and limitations of using nanocarriers for oral delivery of biologics.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Meeting Abstract
Endocrinology & Metabolism
John B. Prins, Haressh Sajiir, Sahar Keshvari, Kuan Yau Wong, Jack Lockett, Michael McGuckin, Sumaira Z. Hasnain
Review
Immunology
Yong Hua Sheng, Sumaira Z. Hasnain
Summary: This article focuses on the dynamic function of mucins and mucus during infection, the regulation of the mucosal barrier, and how pathogens have evolved mechanisms to evade this defense system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yong H. Sheng, Julie M. Davies, Ran Wang, Kuan Yau Wong, Rabina Giri, Yuanhao Yang, Jakob Begun, Timothy H. Florin, Sumaira Z. Hasnain, Michael A. McGuckin
Summary: MUC1 plays a pro-tumorigenic role in colorectal cancer by regulating immune cell activity and interleukin-6 production. These findings provide a theoretical basis for the prevention and treatment of colorectal cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Md. Moniruzzaman, Kuan Yau Wong, Ran Wang, Hamish Symon, Alexandra Mueller, M. Arifur Rahman, Sumaira Z. Hasnain
Summary: IL-20 levels increase in UC patients, and IL-20 treatment can reduce ER stress in epithelial cells. However, this effect is lost in goblet cells. IL-20 has minimal effects on pathology in DSS and Winnie models, but decreases macrophage activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Immunology
Haressh Sajiir, Kuan Yau Wong, Alexandra Mueller, Sahar Keshvari, Ran Wang, Percival Wiid, Graeme Macdonald, John Prins, Michael A. McGuckin, Sumaira Z. Hasnain
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Haressh Sajiir, Kuanyau Wong, Alexander Mueller, Sahar Keshvari, Ran Wang, Graeme A. Macdonald, John Prins, Michael Mcguckin, Sumaira Z. Hasnain
Meeting Abstract
Gastroenterology & Hepatology
Rabina Giri, Robert Gordon, Graham W. Magor, Yaowu He, Thomas Kryza, Tashbib Khan, Veronika Schreiber, Sumaira Z. Hasnain, Adam Ewing, John Hooper, Timothy H. Florin, Andrew Perkins, Manish Gala, Jakob Begun
Meeting Abstract
Gastroenterology & Hepatology
Haressh Sajiir, Kuan Yau Wong, Alexandra Mueller, Sahar Keshvari, Ran Wang, Percival Wiid, Grant Ramm, Graeme Macdonald, John Prins, Michael McGuckin, Sumaira Hasnain
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
H. Sajiir, S. Keshvari, K. Y. Wong, A. Fotheringham, R. Wang, P. Wiid, J. Lockett, G. Macdonald, J. Prins, M. A. McGuckin, S. Z. Hasnain
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhi Qu, Kuan Yau Wong, Md. Moniruzzaman, Jakob Begun, Helder A. Santos, Sumaira Z. Hasnain, Tushar Kumeria, Michael A. McGuckin, Amirali Popat
Summary: The study proposes a smart drug delivery system using functionalized mesoporous silica nanoparticles and pH-responsive polymer to improve the release efficiency and reduce systemic side effects of oral glucocorticoids. Results show that this system can release drugs at colonic pH and demonstrate therapeutic efficacy in a mouse colitis model. Coated nanoparticles significantly decrease cytokine expression in the proximal colon, indicating colonic delivery effectiveness.
ADVANCED THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)