期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 45, 期 5, 页码 960-963出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2013.01.018
关键词
Copper transporter; Development; Cancer; Chemotherapy; Immunity
资金
- Sydney Medical School New Staff Grant
- Disciplines of Physiology, Anatomy and Histology, School of Medical Sciences, University of Sydney
- National Breast Cancer Foundation
- National Health and Medical Research Project [632778]
- National Breast Cancer Foundation [NC-13-10] Funding Source: researchfish
Copper is vital to cell function. The influx of reduced copper ions is controlled by two functionally homologous transmembrane solute carrier transporters CTR1 (encoded by SLC31A1) and CTR2 (encoded by SLC31A2). These copper transporters vary in their expression profiles and intracellular localisation patterns. CTR1 plays roles in the developing embryo as well as regulating homeostasis in the adult mammal. In contrast, the regulation, expression and function of CTR2 is poorly defined. Both are capable of transporting other divalent metal ions and are the primary transporters for platinum-based chemotherapeutic drugs such as cisplatin. This review summarises our current understanding of these two copper transporters and highlights their roles in cellular processes, embryonic development, differentiation, cancer, immunity and disease. (C) 2013 Elsevier Ltd. All rights reserved.
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