Article
Oncology
Yu-Hsuan Hung, Ya-Chin Hou, Shih-Han Hsu, Li-Yun Wang, Ya-Li Tsai, Yan-Shen Shan, Yung-Yeh Su, Wen-Chun Hung, Li-Tzong Chen
Summary: Perineural invasion and neurogenesis are common in pancreatic ductal adenocarcinoma (PDAC), and upregulated expression of semaphorin 3A (SEMA3A) is observed in PDAC. This study found that cancer-secreted SEMA3A promotes neural migration, neurite outgrowth, and neural recruitment, and these effects are dependent on the activation of receptors PLXNA1, NRP2, and MAPK. Inhibition of SEMA3A can reduce neural recruitment, tumor growth, and dissemination in PDAC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Ekaterina P. Kiseleva, Kristina V. Rutto
Summary: This article systematically analyzes the effects of Semaphorin 3A on T-lymphocytes, myeloid dendritic cells, and macrophages based on available literature from the past 20 years. The expression of Semaphorin 3A receptors in these cells is described in detail, and data from human and murine cells are compared. The article presents a comprehensive overview of the interaction between Semaphorin 3A and the mononuclear phagocyte system. Semaphorin 3A signaling mainly results in changes to the cytoskeletal machinery and cellular morphology, which regulate pathways involved in immune cell migration, adhesion, and cell-cell cooperation. It is increasingly recognized that Semaphorin 3A plays a crucial role in various phases of immune responses and is associated with many human diseases, making it a potential therapeutic target.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhaoyichun Zhang, Lei Lu, Tao Ye, Shibin Yu, Jing Zhang, Mian Zhang, Feng He, Qian Liu, Hongxu Yang, Jianying Feng
Summary: This study demonstrates the biological function of Sema4D/Plexin-B1 in early-stage TMJ osteoarthritis. Inhibiting Sema4D/Plexin-B1 signaling represents a promising strategy for new therapeutic approaches to osteoarthritis.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Shaoyu Wang, Kui Li, Hui Gao, Zepeng Liu, Shuang Shi, Qiang Tan, Zhengguang Wang
Summary: USP8 plays a significant role in the proliferation and early differentiation of sheep skeletal muscle satellite cells, with its expression level significantly increased during differentiation. Knocking down USP8 can promote early differentiation of satellite cells and suppress muscle satellite cell proliferation.
CZECH JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Pathology
Zachary M. Howard, Jeovanna Lowe, Anton J. Blatnik, Deztani Roberts, Arthur H. M. Burghes, Shyam S. Bansal, Jill A. Rafael-Fortney
Summary: The study found that mdx and Het mice have increased levels of chemokines and cytokines, with Het mice showing higher levels. Additionally, Het quadriceps contain more neutrophils and infiltrating monocytes, and have higher fibrotic and inflammatory gene expression levels in myeloid cells. These differences may affect the regenerative potential of dystrophic diaphragms and represent an improved model for testing anti-inflammatory therapies for DMD.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Zhaoze Sun, Kaixian Yan, Shuang Liu, Xijiao Yu, Jingyi Xu, Jinhua Liu, Shu Li
Summary: This study investigated the impact of Sema3A on osteogenic differentiation in inflammatory environments, revealing that Sema3A can protect BMSCs from LPS-mediated inhibition and promote bone regeneration.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Biology
Dan Yang, Hideaki Oike, Mitsuhiro Furuse, Shinobu Yasuo
Summary: The study found that the circadian clock in NIH3T3 cells can respond to periodic stimulation cycles of dexamethasone, entraining to 22 and 24-hour cycles during the stimulation period. Irregular dexamethasone treatment disrupted the expression of several clock and cell cycle genes, causing overall upregulation and phase shifts. Regular stimulation with dexamethasone also resulted in upregulation of certain genes, showing different effects compared to irregular treatment.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Veterinary Sciences
Yume Kitagawa, Kaho Hayakawa, Daichi Oikawa, Kazuki Ikeda, Maki Ikeda, Daiki Harada, Mitsuhiro Furuse
Summary: In modern society, stress caused by relationships and emotions is a significant social issue. This study aimed to investigate the impact of repeated restraint stress on the fatty acid composition and amino acid concentration in the skin of ICR mice. The results showed changes in fatty acid composition with an increase in saturated fatty acids and a decrease in unsaturated fatty acids, potentially leading to skin inflammation.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Cell Biology
Koichi Ojima, Masahiro Kigaki, Emi Ichimura, Takahiro Suzuki, Ken Kobayashi, Susumu Muroya, Takanori Nishimura
Summary: The dynamics of different isoforms of myosin in skeletal muscle have been studied using a mouse model expressing fluorescently tagged slow and fast myosin. The results showed that the response to protein turnover disturbance varied between slow and fast myofibers. These findings highlight the importance of studying endogenous myosin dynamics in different muscle fiber types.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Food Science & Technology
Masaya Ogata, Jumpei Uchiyama, Abdulatef M. Ahhmed, Seiichi Sakuraoka, Satoshi Taharaguchi, Ryoichi Sakata, Wataru Mizunoya, Shiro Takeda
Summary: The study investigated the inherent bacteria contributing to ACE inhibitory and antioxidant activities in dry-cured meat products. Results showed that different species of Lactobacillales order were important for the functional activities of the products.
Article
Biochemistry & Molecular Biology
Mohamed Z. Elhussiny, Phuong Tran, Ying Wang, Yoshimitsu Ouchi, Shogo Haraguchi, Elizabeth R. Gilbert, Mark A. Cline, Takashi Bungo, Mitsuhiro Furuse, Vishwajit S. Chowdhury
Summary: The study found that central injection of taurine can rapidly change the concentrations of free amino acids in the brain and plasma, which may play a role in thermoregulation, food intake, and stress response in chicks.
Article
Agriculture, Dairy & Animal Science
Phuong Tran, Mohamed Z. Elhussiny, Yuriko Tsuru, Ying Wang, Guofeng Han, Vishwajit S. Chowdhury, Mitsuhiro Furuse
Summary: Ornithine has been identified as a potential satiety signal in the brains of neonatal chicks. The study found that co-injection of the neuropeptide Y (NPY) and ornithine attenuated the orexigenic effect induced by NPY and modified the anabolic effect of central NPY. These findings suggest that brain ornithine interacts with NPY to regulate food intake in neonatal chicks.
JOURNAL OF POULTRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Susumu Muroya, Riko Nomura, Hirotaka Nagai, Koichi Ojima, Kazutsugu Matsukawa
Summary: This study aimed to compare the interbreed differences in muscle metabolites between Japanese Brown and Japanese Black beef with high marbling. By analyzing the metabolomic profiles of the muscles, flavor-related metabolites were identified. The results showed that there were differences in muscle metabolism and maturity between Japanese Brown beef and Japanese Black beef.
Article
Biochemistry & Molecular Biology
Tsubasa Ihara, Mizuki Hamada, Mitsuhiro Furuse
Summary: Heredity is a major factor in the pathogenesis of depression, but the specific mechanism is not fully understood. The present study suggests that the paternal strain has a significant impact on locomotor activity and depression-like behavior, potentially through the dysregulation of amino acid metabolism in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Shoko Sawano, Misaki Fukushima, Taiki Akasaka, Mako Nakamura, Ryuichi Tatsumi, Yoshihide Ikeuchi, Wataru Mizunoya
Summary: Skeletal muscle atrophy due to inactivity leads to changes in gene expression. However, little is known about the patterns of up-and downregulated gene expression during long-term and equilibrated muscle atrophy. This study used RNA-Seq to examine the changes in gene expression in long-term denervated mouse muscles. The results revealed that the expression of several genes, including E230016M11Rik, was significantly upregulated in both soleus and extensor digitorum longus (EDL) muscles.
Article
Oncology
Takahiro Maeno, Rio Arimatsu, Koichi Ojima, Yuki Yamaya, Hikaru Imakyure, Naruha Watanabe, Yusuke Komiya, Ken Kobayashi, Mako Nakamura, Takanori Nishimura, Ryuichi Tatsumi, Takahiro Suzuki
Summary: Satellite cells play a crucial role in skeletal muscle regeneration and hypertrophy through the formation of nascent myofibers. This study investigated the role of netrin-4, a multi-potent modulator, in regulating myofiber type commitment and myotube formation. The findings suggest that satellite cells synthesize netrin-4 during the initiation stage of myogenic differentiation to promote their own fusion through the MyoD-Myomixer signaling axis.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Shiro Takeda, Abdulatef M. Ahhmed, Kazuki Sogawa, Saki Mouri, Sakurako Kaneko, Ryoichi Sakata, Wataru Mizunoya
Summary: Venison, a type of game meat, contains bioactive peptides with antioxidative properties. The study investigated the antioxidant activity of venison treated by in vitro cooking and digestion. The results showed that the digested venison had increased antioxidant activity and contained two peptides with high DPPH-RS activities.
ANIMAL SCIENCE JOURNAL
(2023)
Article
Cell Biology
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Takashi Nakashima, Shoko Okuda, Yoshitaka Manabe, Shoko Sawano, Wataru Mizunoya, Ryuki Kaneko, Sakiho Tanaka, Takahiro Maeno, Yuji Matsuyoshi, Miyumi Seki, So Kuwakado, Kahona Zushi, Nasibeh Daneshvar, Mako Nakamura, Takahiro Suzuki, Kenji Sunagawa, Judy E. Anderson, Ronald E. Allen, Ryuichi Tatsumi
Summary: Mechanical perturbation triggers activation of myogenic stem cells, but with aging, extracellular HGF undergoes nitration and loses its binding with c-met, disturbing muscle homeostasis. These findings highlight the inhibitory effects of HGF nitration on myogenic stem cell dynamics and contribute to understanding age-related muscle atrophy and impaired regeneration.
Article
Biochemistry & Molecular Biology
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Miyumi Seki, Sakiho Tanaka, Yuji Matsuyoshi, Takashi Nakashima, Shoko Sawano, Wataru Mizunoya, Takahiro Suzuki, Mako Nakamura, Judy E. Anderson, Ryuichi Tatsumi
Summary: Protein tyrosine residue nitration is associated with changes in protein activity and function, and can be used to monitor the progression of pathological disorders. This study found that nitration affects muscle growth and regeneration, specifically impacting the functionality of hepatocyte growth factor. Nitration may perturb the dynamics of myogenic stem cells, leading to the progression of muscular disorders.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Veterinary Sciences
Emi Taniguchi, Ayumi Hattori, Kaito Kurogi, Yukihiro Hishida, Fumiko Watanabe, Mitsuhiro Furuse, Shinobu Yasuo
Summary: The study found that L-ornithine can stimulate the release of GH in mice. After oral administration of L-ornithine, the increase in GH release was first observed 150 minutes later and lasted for more than 90 minutes. This increase was delayed compared to the reported levels of L-ornithine in plasma and tissues.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Alaa Elgaabari, Nana Imatomi, Hirochika Kido, Miyumi Seki, Sakiho Tanaka, Yuji Matsuyoshi, Takashi Nakashima, Shoko Sawano, Wataru Mizunoya, Takahiro Suzuki, Mako Nakamura, Judy E. Anderson, Ryuichi Tatsumi
Summary: This study investigated the impact of protein tyrosine residue nitration on muscle growth, regeneration, and pathological disorders. The findings suggest that nitration disrupts the function of hepatocyte growth factor and may stimulate the progression of muscular disorders and diseases.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
