Review
Oncology
Marie Rajtmajerova, Andriy Trailin, Vaclav Liska, Kari Hemminki, Filip Ambrozkiewicz
Summary: The interplay between tumor and immune system is crucial in disease progression, and non-coding RNAs play an important role in the regulation of immune response. Understanding the mechanisms underlying tumor evolution is crucial for successful therapy.
Article
Biochemistry & Molecular Biology
Barbara Bellei, Silvia Caputo, Emilia Migliano, Gianluca Lopez, Valeria Marcaccini, Carlo Cota, Mauro Picardo
Summary: The study showed that the molecule Onco-P20, a combination of paclitaxel and hyaluronic acid, targets cells expressing high levels of CD44 and induces apoptotic cell death in sensitive carcinoma cells while causing growth arrest and gene expression changes in less sensitive fibroblasts. Onco-P20-treated fibroblasts exhibited reduced growth factor production, downmodulation of the Wnt signaling pathway, and acquired a pro-inflammatory profile, leading to reduced proliferation rate of carcinoma cells in their presence. Fibroblasts from skin cancer lesions also displayed anti-neoplastic activity under Onco-P20 treatment, suggesting it as a potential alternative therapy for NMSC.
Article
Oncology
Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara, Okio Hino, Liying Yang, Reo Maruyama, Akira Katakura, Takehiro Yasukawa, Akira Orimo
Summary: Cancer-associated fibroblasts (CAFs) promote tumor growth in human breast cancers. RUNX3 expression is higher in CAFs from cancerous regions compared to non-cancerous regions in breast cancer patients. Knockdown of RUNX3 in CAFs attenuates tumor growth and reduces cancer cell proliferation and microvessel formation.
Review
Oncology
Yi Li, Changyuan Wang, Ting Huang, Xijie Yu, Bole Tian
Summary: Breast cancer deaths are primarily caused by metastasis. There are several treatment options, but limited options for preventing or inhibiting breast tumor metastases. Studies have focused on the importance of the tumor microenvironment (TME) in metastasis of breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Llara Prieto-Fernandez, Irene Montoro-Jimenez, Beatriz de Luxan-Delgado, Maria Otero-Rosales, Juan P. Rodrigo, Fernando Calvo, Juana M. Garcia-Pedrero, Saul Alvarez-Teijeiro
Summary: Head and neck cancers (HNC) are aggressive malignancies with high mortality rates. Understanding the molecular processes of tumor formation and progression is crucial for improving diagnosis, prognosis, and treatment. Cancer-associated fibroblasts (CAFs) play a vital role in the tumor microenvironment, impacting tumor growth and metastasis. Targeting CAF functions could have a significant impact on HNC therapeutics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Charalampos Fotsitzoudis, Asimina Koulouridi, Ippokratis Messaritakis, Theocharis Konstantinidis, Nikolaos Gouvas, John Tsiaoussis, John Souglakos
Summary: Tumor microenvironment, including cancer-associated fibroblasts (CAFs), plays a significant role in tumor growth, metastasis, and therapy resistance. Detecting CAFs is crucial for prognosis assessment and potential treatment targets, but further research is needed.
Review
Oncology
Umar Mehraj, Abid Hamid Dar, Nissar A. Wani, Manzoor A. Mir
Summary: Breast cancer is the most common tumor type in women, and chemoresistance remains a significant challenge despite advancements in diagnosis and treatment. The tumor microenvironment plays a central role in opposing chemotherapy agents, with various stromal and immune cells contributing to the acquisition of resistant phenotypes. Understanding the role of TME components and cells in breast cancer chemoresistance is crucial for improving treatment outcomes.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Immunology
Zhiping Wang, Mengyan Zhang, Lingyun Liu, Yan Yang, Jianjian Qiu, Yilin Yu, Jiancheng Li
Summary: This study investigates the impact and prognostic significance of exosomal proteins derived from cancer-associated fibroblasts (CAFs) in esophageal squamous cell carcinoma (ESCC). The findings reveal that exosomes derived from CAFs enhance the proliferation, invasion, and migration of esophageal cancer cells. A prognostic signature based on CAFs-derived exosomal proteins is established, and it is found to serve as a reliable biomarker for predicting prognosis and evaluating the immune microenvironment in ESCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Bo Xiao, Mingwei Li, Mingxuan Cui, Chengliang Yin, Bo Zhang
Summary: The purpose of this study was to establish a comprehensive tumour microenvironment (TME)-relevant prognostic gene and target miRNA network for breast cancer patients. Based on a large-scale screening of TME-relevant prognostic genes for breast cancer patients, a prognostic model was established. The relationships between the potential TME prognostic genes and the prognosis of breast cancer patients were explored, and the functions of each primary TME member were investigated in the breast cancer cell line.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Shih-Hsuan Cheng, Hsin-Ying Clair Chiou, Jiunn-Wei Wang, Ming-Hong Lin
Summary: Gastrointestinal (GI) cancers are a major cause of cancer-related deaths worldwide. Despite advancements in current treatments, high recurrence rates still pose a challenge for patients with GI cancers. The tumor microenvironment (TME) plays a crucial role in tumor progression, metastasis, and chemotherapy resistance, particularly through the interaction of cytokines/chemokines produced by cancer-associated fibroblasts (CAFs). Understanding this crosstalk between CAFs and the TME can open new avenues for reducing therapeutic recurrence in GI cancers.
Article
Immunology
Tsz Kin Mak, Xing Li, Huaping Huang, Kaiming Wu, Zhijian Huang, Yulong He, Changhua Zhang
Summary: This study identifies the role of cancer-associated fibroblasts (CAFs) in gastric cancer (GC) by analyzing their association with prognosis, tumor microenvironment, cancer stem cells, immune response, and drug sensitivity using the CAFS-score. The findings provide valuable insights for improving prognosis and response to immunotherapy in GC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wenjing Gong, Yang Guo, Hang Yuan, Rui Chai, Ziang Wan, Boan Zheng, Xinye Hu, Bingchen Chen, Shan Gao, Qiaoqiong Dai, Peng Yu, Shiliang Tu
Summary: Hypoxia and exosome-mediated transfer of miRNAs from cancer-associated fibroblasts (CAFs) promote colorectal cancer (CRC) progression.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maria Francesca Santolla, Marianna Talia, Marcello Maggiolini
Summary: The study identified higher expression levels of FGF2 and S100A4 in TNBC patients compared to non-TNBC patients, and demonstrated that FGF2 induces the upregulation and secretion of S100A4 in TNBC cells via FGFR1 signaling pathway. This activation leads to angiogenic effects in vascular endothelial cells and promotes the migration of cancer-associated fibroblasts in TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Turid Hellevik, Rodrigo Berzaghi, Kristin Lode, Ashraful Islam, Inigo Martinez-Zubiaurre
Summary: Radiotherapy not only kills malignant cells through ionizing radiation, but also activates anti-tumor immune responses. Cancer-associated fibroblasts (CAFs) are important components of the tumor microenvironment, playing central roles in cancer development and immune evasion. Despite the known immunoregulatory functions of CAFs, the interaction between CAFs and immune cells after radiation remains poorly understood.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
MingHua Cui, YueHui Liu, Li Cheng, Tao Li, YongZhi Deng, Da Liu
Summary: Ovarian cancer is a highly deadly malignancy among women, and its complex pathogenesis remains largely unknown. The tumor microenvironment plays a crucial role in tumor progression and treatment. MicroRNAs have been shown to regulate ovarian cancer development by affecting the tumor microenvironment. Therefore, identifying new tumor biomarkers and therapeutic targets is of great significance for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Xiaolong Shi, Yufei Zhou, Pei Guo, Jingyao Ren, He Zhang, Qiqi Dong, Chunji Jiang, Chao Zhong, Zheng Zhang, Shubo Wan, Xinhua Zhao, Haiqiu Yu
Summary: Intercropping of peanut and sorghum can improve soil properties and microbial community structure, enhancing nutrient availability, enzymatic activities, and plant adaptability under salt stress conditions.
LAND DEGRADATION & DEVELOPMENT
(2023)
Article
Computer Science, Artificial Intelligence
Chao Wang, Yunchu Zhang, Yanfei Zhou, Shaohan Sun, Hanyuan Zhang, Yepeng Wang
Summary: This paper proposes a novel algorithm DFV-YOLOv5 for occupancy detection, which tackles the problems of slow model convergence and poor detection performance for densely occluded targets. The proposed algorithm uses the anchor-free mechanism and decoupled detection heads to improve the detection accuracy and robustness. Experimental results show the practicality and superiority of the algorithm in occupancy detection compared to mainstream target detection models.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Engineering, Geological
Chao Zhang, Chao Ding, Yun Zhou, Guangyu Wang, Fei Shi, Weiyuan Huang
Summary: A novel stair system is proposed in this study, which is a prefabricated reinforced concrete staircase isolated by high damping rubber (HDR) bearings that can alleviate the detrimental diagonal bracing effect of traditional staircases under lateral inputs. The remarkable properties of HDR bearings are verified through material tests, and a parametric study is conducted to understand the behavior of the developed system. The results confirm that the proposed system can mitigate the detrimental effect and improve the seismic performance, with the rubber thickness of the HDR bearings playing a significant role.
BULLETIN OF EARTHQUAKE ENGINEERING
(2023)
Article
Environmental Sciences
Haolan Wang, Wenlong Zhang, Yi Li, Yu Gao, Nan Yang, Lihua Niu, Huanjun Zhang, Longfei Wang
Summary: This study investigates the impact of trophic interactions on the assembly of multi-trophic microbial communities and nitrogen transformation potential in typical urban river bends. The results indicate that trophic interactions strongly shape microbial communities, leading to increased abundance in multitrophic microbial communities and enhanced nitrogen transformation potential. This research provides a theoretical basis for the regulation and restoration of urban rivers.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Biochemical Research Methods
Wenxian Wang, Dan Yang, Yufei Zhou, Yuding Zhang, Lijiao Guan, Xianfen Zhang, Weiming Xue, Saipeng Huang
Summary: This study successfully constructed highly sensitive and functional carbon quantum dots for the detection of tyrosinase activity. These carbon quantum dots showed excellent linear relationship and broad linear range with high accuracy and recovery in human serum samples. Furthermore, they demonstrated good cellular imaging capability and biocompatibility, making them suitable for intracellular tyrosinase detection. This research holds potential biomedical applications in early diagnosis of melanoma and other tyrosinase-related diseases.
JOURNAL OF FLUORESCENCE
(2023)
Article
Surgery
Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Yang-Dan Liu, Yu-Xin Liu, Dan-Ning Zheng, Yi-Fan Zhang, Li Yu
Summary: Sal-B could improve the effect of fat transplantation by inhibiting the polarization of M1 macrophages through NF-kappa B signaling. The results showed that Sal-B significantly improved fat graft survival and attenuated adipose tissue fibrosis and inflammation. In addition, Sal-B had an inhibitory effect on NF-kappa B signaling.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Computer Science, Information Systems
Yujie Zhou, Ruyan Wang, Xingyue Mo, Zhidu Li, Tong Tang
Summary: This study proposes a robust hierarchical federated learning (R-HFL) framework that utilizes cloud-edge cooperation to enhance communication efficiency and system resistance to abnormal behaviors in distributed machine learning training.
Article
Management
James M. Raymo, Yanfei Zhou
Summary: A significant number of impoverished mothers in Japan do not work, which defies conventional theories of labor supply and the expectation of gender equality. Unlike in the United States and other countries, well-known barriers to employment for low-income mothers do not seem to apply in Japan. This study seeks to understand this phenomenon by examining the reasons given by these mothers for not working and the factors influencing maternal employment based on their husbands' income. The prioritization of childrearing and traditional gender roles were found to be strong predictors of non-employment among all mothers, regardless of their husbands' income level.
GENDER WORK AND ORGANIZATION
(2023)
Article
Plant Sciences
Xiaolong Shi, Yufei Zhou, Xinhua Zhao, Pei Guo, Jingyao Ren, He Zhang, Qiqi Dong, Zheng Zhang, Haiqiu Yu, Shubo Wan
Summary: Soil metabolomics and metagenome sequencing were used to investigate the salt-stress response in peanuts intercropped with sorghum. The study found that carbohydrate metabolism was the most differentially expressed pathway, with certain metabolites more abundant in intercropped peanuts under salt stress. In addition, there was a higher abundance of specific microbial taxa in intercropped peanuts under salt stress. These findings suggest that intercropping can indirectly influence beneficial microbial communities and potentially enhance peanut's salt tolerance.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Environmental Sciences
Nan Yang, Xing Hou, Yi Li, Huanjun Zhang, Jun Wang, Xiaodong Hu, Wenlong Zhang
Summary: This study investigates the effects of water diversion on microbial communities in different habitats. It finds that increased connectivity between aquatic habitats due to water diversion can homogenize microbial communities and reduce heterogeneity. Stochastic processes play an important role in shaping microbial community assembly, with dispersal limitation and variable selection being the dominant mechanisms in isolated lakes. The study provides important insights for water resource allocation and project management.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Yunwen Xue, Minhua Gu, Cuilan Chen, Yujian Yao, Yuzhen Li, Guohu Weng, Yong Gu
Summary: The ApoE mimetic peptide COG1410 can alleviate blood-brain barrier (BBB) damage and neuroinflammation caused by cerebral ischemia-reperfusion injury.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Plant Sciences
Yan Wang, Kaitai Liu, Yunyun Zhou, Yong Chen, Chenzhong Jin, Yihong Hu
Summary: This study investigated the relationship between phenolic acid biosynthesis and continuous cropping (CC) in Polygonatum odoratum roots through miRNA-seq and RNA-seq analysis. Several key DEGs and DEMs involved in phenolic acid synthesis were identified, providing a foundation for further understanding phenolic acid biosynthesis during CC of P. odoratum roots.
Article
Education & Educational Research
Leishan Shi, Shuzhen Chen, Yanfang Zhou
Summary: Based on social capital theory, this study investigates the relationship between social capital and teachers' Creative Teaching Behavior (CTB) in school organizations. The results show that social capital positively predicts primary school teachers' CTB. It is found that social capital influences CTB through the mediating effects of knowledge sharing and creative teaching self-efficacy. The findings have theoretical and empirical implications for teachers' CTB.
THINKING SKILLS AND CREATIVITY
(2023)
Article
Area Studies
Yufei Zhou
Summary: This paper discusses the commodification of Tibetan Mastiffs and the care relationship between humans and dogs. Tibetan pastoralists and dogs have a reciprocal yet distanced care relationship, while breeders of Tibetan Mastiffs focus on their ferociousness, resulting in a more dedicated but unilateral and dangerous care approach. The unintended consequence of breeders' care is that they raise dogs that sometimes bite, due to the transformation of dogs' guarding abilities from ethical virtue to commercial value.
Review
Biochemistry & Molecular Biology
Kexin Li, Yufeng Jiang, Yiyao Zeng, Yafeng Zhou
Summary: Arrhythmogenic cardiomyopathy (ACM) is a heterogeneous disorder characterized by the replacement of cardiac myocytes with fibro-fatty tissues, leading to abnormal excitation-contraction (EC) coupling and a range of malignant events. The pathogenesis of ACM involves mutation variants in desmosomal or non-desmosomal gene loci, as well as various external factors. Ion channel alterations, autophagy and non-desmosomal variants are also important components in the development of ACM. Reviewing recent studies on these topics is crucial for better diagnosing and treating the molecular phase of ACM.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
