期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 44, 期 5, 页码 698-702出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2012.01.019
关键词
Cell adhesion; IgG superfamily of CAMs; Hh signaling; Myoblast
资金
- Spanish MICINN [BFU2010-16031]
- Comunidad Autonoma de Madrid (CAM) [P-SAL-0190-2006]
- Fundacion ONCE
- Fundaluce
- CIBERER
- Fundacion Ramon Areces
- CSIC [JAEDOC-012]
- MICINN [(BES-2008-005457), (AP2009-0349)]
Cdon and Boc, and their Drosophila homologues Ihog and Boi, are evolutionary conserved transmembrane glycoproteins belonging to a subgroup of the Immunoglobulin superfamily of cell adhesion molecules (CAMs). Initially isolated in vertebrates as CAMs that link cadherin function with MAPK signaling in myoblast differentiation, they have thereafter been shown to act as essential receptors for the Hedgehog (Hh) family of secreted proteins. They associate with both ligand and other Hh receptor components, including Ptch and Gas1, thus forming homo- and heteromeric complexes. In Drosophila, they are also involved in ligand processing and release from Hh producing cells. Cdon/Boc and Ihog/Boi can substitute one another and play redundant functions is some contexts. In addition, Boc, but not Cdon, mediates axon guidance information provided by Hh in specific neuronal populations, whereas mutations in the CDON cause holoprosencephaly, a human congenital anomaly defined by forebrain midline defects prominently associated with diminished Hh pathway activity. (c) 2012 Elsevier Ltd. All rights reserved.
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