期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 44, 期 5, 页码 714-717出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2012.01.024
关键词
Collagen XIII; Transmembrane; Shedding; Neuromuscular junction
资金
- Academy of Finland Research Council for Health [127674, 136402, 251314, 138866]
- Sigrid Juselius Foundation
- Cancer Foundation Finland sr [110111] Funding Source: researchfish
- Academy of Finland (AKA) [127674, 136402, 127674, 138866, 138866, 136402] Funding Source: Academy of Finland (AKA)
Collagen XIII and the homologous collagens XXIII and XXV form a subgroup of type II transmembrane proteins within the collagen superfamily. Collagen XIII consists of a short cytosolic domain, a transmembrane domain and a large extracellular ectodomain, which may be shed into the pericellular matrix. It has been proposed that collagen XIII may function as an adhesion molecule, due to its cellular localization at focal contacts, numerous interactions with basement membrane (BM) and other extracellular matrix (ECM) proteins and expression at various cell-cell and cell-matrix junctions. Recent in vivo studies highlight its involvement in the development, differentiation and maturation of musculoskeletal tissues and vessels and in maintaining tissue integrity. (c) 2012 Elsevier Ltd. All rights reserved.
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