Article
Biochemistry & Molecular Biology
Xiong Wang, Fan Liu, Qin An, Wenli Wang, Zhimei Cheng, Yunping Dai, Qingyong Meng, Yali Zhang
Summary: Lactoferrin (Ltf) plays a protective role in skeletal muscle by promoting the proliferation of satellite cells (SCs) and skeletal muscle regeneration. It holds promise as a novel therapeutic agent for skeletal muscle injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Farheen Badrealam Khan, Irfa Anwar, Elrashdy M. Redwan, Abdulrasheed Palakkott, Arshida Ashraf, Jaleel Kizhakkayil, Rabah Iratni, Sajid Maqsood, Mohammed Akli Ayoub
Summary: Lactoferrin has been found to have antidiabetic properties by activating insulin receptors and their downstream signaling pathways. This suggests that lactoferrin may be the bioactive component responsible for the antidiabetic properties of camel milk.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Dunja Kokai, Bojana Stanic, Biljana Tesic, Dragana Samardzija Nenadov, Kristina Pogrmic-Majkic, Svetlana Fa Nedeljkovic, Nebojsa Andric
Summary: This study found that DBP can induce pro-angiogenic effects on human vascular endothelial cells, and this effect is mediated by the activation of ERK1/2, PI3K-Akt, and NO signaling pathways through ER and GPER dependent mechanisms.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Ahmed A. Noser, Ihsan A. Shehadi, Aboubakr H. Abdelmonsef, Maha M. Salem
Summary: A series of novel pyrazolinone chalcones were synthesized and screened for their ability to inhibit cancer proliferation and metastasis. Compound 6b exhibited the highest binding energy and most effective cytotoxic impact, inhibiting the PI3K/Akt and Raf-1/ERK1/2 signaling pathways.
Article
Cell Biology
Zeinab Babaei, Mojtaba Panjehpour, Hadi Parsian, Mahmoud Aghaei
Summary: In this study, the researchers investigated the pathological role of VEGFR-3 and the effects of SAR131675 in ovarian cancer cells. The results showed that SAR131675 effectively inhibited VEGFR-3/ERK1/2/AKT pathway, leading to the suppression of proliferation and migration, as well as the promotion of cell cycle arrest and apoptosis in ovarian cancer cells.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Liwei Liu, Yan Cheng, Fasu Zhang, Jin Chen, Pingping Tian, Wei Shi, Fei Zhou, Mingya Yang, Min Zhou, Bo Liu
Summary: The combination of CD3/CD28/IL-2/GM-CSF is the most effective in stimulating CAR-T cell proliferation and CXCR3 expression in vitro. CD3/CD28/IL-2 induces CXCR3 expression through the PI3K/APK pathway, while GM-CSF induces CXCR3 expression through the ERK1/2 pathway. CAR-T cells with high CXCR3 expression show enhanced chemotaxis ability to hepatocellular carcinoma, leading to the inhibition of tumor growth in vivo.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Immunology
Ahmed A. Al-Qahtani, Ioanna Pantazi, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The study found that the S protein of SARS-CoV-2 suppresses inflammatory responses in alveolar epithelial type II cells at early stages of infection by activating the PI3K/AKT pathway. Additionally, when combined with TLR2 signals, the S protein enhances PAI-1 expression, potentially affecting the local coagulation cascade.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jirapak Ruttanapattanakul, Nitwara Wikan, Siriporn Okonogi, Mingkwan Na Takuathung, Pensiri Buacheen, Pornsiri Pitchakarn, Saranyapin Potikanond, Wutigri Nimlamool
Summary: Boesenbergia rotunda extract promotes wound healing by stimulating cell proliferation, activating the ERK1/2 and Akt signaling pathways, but does not enhance cell migration. These findings support the potential of BR as a wound-healing promoting agent.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Wenhao Yu, Jinghui Liang, Tao Fang, Jin Jiang, Renchang Zhao, Rongyang Li, Jingyi Han, Hui Tian
Summary: This study discovered that the expression of EIF4A3, a eukaryotic translation initiation factor, was significantly higher in LUAD tissues and was closely associated with poor prognosis. The knockdown of EIF4A3 inhibited the proliferation, invasion, and migration of LUAD cells, and it was found that EIF4A3 could interact with Flotillin-1 and positively regulate the expression of FLOT1. The study suggests that EIF4A3 could be a molecular diagnostic and prognostic therapeutic target in LUAD.
MOLECULAR CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Clemens Holz, Sandra Lange, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Hugo Murua Escobar, Christian Junghanss, Anna Richter
Summary: Numerous hematologic neoplasms, including acute B-lymphoblastic leukemia (B-ALL), are characterized by overexpression of anti-apoptotic BCL-2 family proteins. Recent data indicated that combined BCL-2 and PI3K/AKT inhibition has synergistic anti-proliferative effects on B-ALL cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Carla L. Alves, Henrik J. Ditzel
Summary: The PI3K/AKT/mTOR pathway plays a crucial role in estrogen receptor-positive breast cancer tumorigenesis and drug resistance, making it a highly attractive therapeutic target. Several inhibitors targeting this pathway are currently under clinical development. The recent approval of the PIK3CA isoform-specific inhibitor alpelisib and the pan-AKT inhibitor capivasertib, in combination with fulvestrant, has provided new treatment options for advanced estrogen receptor-positive breast cancer patients. However, the clinical development of multiple inhibitors and incorporating CDK4/6 inhibitors into the standard treatment has complicated the personalization of therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Juan Jin, Hui Yang, Lili Hu, Yinghong Wang, Wenyong Wu, Chengmu Hu, Kun Wu, Zehua Wu, Wenming Cheng, Yan Huang
Summary: Inonotsuoxide B suppresses the proliferation and activation of HSCs by inhibiting the PI3K/AKT and ERK1/2 signaling pathways.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Food Science & Technology
Hongdong Song, Yijie Yang, Bo Li
Summary: The study identified a tripeptide Hyp-Asp-Gly (ODG) derived from collagen as the active ingredient responsible for inhibiting platelet activation. ODG showed broad-spectrum inhibition of platelet activation induced by collagen, thrombin, and adenosine diphosphate (ADP), and it remained intact during simulated gastrointestinal digestion and absorption. ODG had no significant effect on the PLC-PKC-Ca2+ pathway, but it inhibited the PI3K/Akt-MAPK/ERK1/2 signaling. ODG exhibited in vivo anti-thrombosis activity without bleeding risk. This study provides insight into the mechanism of action of collagen peptides and highlights the potential use of ODG as a functional component to combat cardiovascular thrombosis.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Food Science & Technology
Huiying Li, Qianqian Yao, Chaonan Li, Linlin Fan, Haoming Wu, Nan Zheng, Jiaqi Wang
Summary: This study found that lactoferrin (LF) can suppress the development of colorectal cancer induced by type 2 diabetes (T2D) by regulating the NT5DC3 protein and the PI3K/AKT/mTOR signaling pathway. Further experiments confirmed that LF specifically binds to the NT5DC3 protein and activates its phosphorylation to inhibit T2D-induced colon tumor development, suggesting a new therapeutic strategy for cancer prevention.
Article
Cell & Tissue Engineering
Jiachen Sun, Hongqing Zhao, Chuan'an Shen, Shiyi Li, Wen Zhang, Jinglong Ma, Zhisheng Li, Ming Zhang, Jianqiu Yang
Summary: Aging affects the function of epidermal stem cells (EpiSCs) and wound healing by reducing the activity of the PI3K/Akt pathway. Tideglusib can promote the proliferation, migration, and wound healing of EpiSCs by activating the PI3K/Akt pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)