期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 44, 期 11, 页码 1847-1851出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2012.07.013
关键词
Pol III; Noncoding RNA; tRNA; 5S rRNA; 7SL RNA
资金
- State Key Development Program for Basic Research of China (973) [2011CBA01103]
- National Natural Science Foundation of China [31071132, 81171074]
- CAS [1731112304041]
- USTC [WK2070000010]
A range of noncoding RNAs are transcribed by pol III. A lot of them such as tRNA, 7SL RNA, 7SK RNA, 5S RNA, MRP RNA, Y RNAs, Hi RNA, and vault RNAs are considered as house keeping RNAs essential for eukaryotic cells. In recent years, researchers started to recognize the existence of unconventional functions of many pol III transcripts other than classical house keeping roles. Therefore, these ncRNAs could now be viewed as molecules with functional regulatory signals as well as cellular building blocks. These noncoding RNAs, all transcribed by pol III, may assemble regulatory networks with analogy to signaling pathways in eukaryotic cells. In this review we discuss these unconventional roles of pol III transcripts. (C) 2012 Elsevier Ltd. All rights reserved.
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