期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 43, 期 12, 页码 1655-1659出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2011.08.007
关键词
Peptidoglycan; O-Acetylation; O-Acetyltransferase; O-Acetylesterase; Lysozyme; Innate immunity
资金
- Canadian institutes for Health Research [MOP81223]
The O-acetylation of peptidoglycan is now known to occur in 50 different bacterial species, both Gram positive and Gram negative, including a number of important human pathogens. This modification to the essential cell wall component of bacteria provides both a level of control over endogenous autolysins and protection from the lysozymes of innate immune systems. In this review, we describe the details of the pathways for peptidoglycan O-acetylation that are now beginning to emerge and we explore the possibility that the associated enzymes may present new candidates for antibacterial targets. (C) 2011 Elsevier Ltd. All rights reserved.
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