Review
Biochemistry & Molecular Biology
Kazuki Nagata, Chiharu Nishiyama
Summary: Mast cells play critical roles in immune responses as initiators and suppressors, with IL-10 serving as a key anti-inflammatory cytokine in regulating their functions. IL-10 exerts diverse effects on mast cells in vivo and in vitro, influencing tissue homeostasis and immune-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Guido H. Falduto, Annika Pfeiffer, Andrea Luker, Dean D. Metcalfe, Ana Olivera
Summary: Mast cells are tissue-resident immune cells that play important roles in allergic inflammation through IgE-mediated mechanisms, but also have antibody-independent biological functions. Recent research has shed light on the diverse roles of mast cells in health and disease, as well as potential novel therapeutic approaches targeting mast cell activity.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Zhao Wang, Xi Zhao, Hongmei Zhou, Delu Che, Xiaojie Du, Dan Ye, Weihui Zeng, Songmei Geng
Summary: Mast cell activation is associated with the pathogenesis of various immune dysregulatory skin disorders. Recent studies have shown that the activation of an IgE-independent pseudo-allergic route is mainly mediated through Mas-Related G protein-coupled receptor X2 (MRGPRX2) and regulated by Ryanodine receptor (RYR). This finding provides insights into the role of RYR in MRGPRX2-mediated pseudo-allergic dermatitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Jessica Buck, Nikhil S. Joshi
Summary: NFAT5 transcription factor regulates T cell exhaustion during cancer but not during chronic viral infection.
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Cardiac & Cardiovascular Systems
Li Ni, Satadru K. Lahiri, Jiali Nie, Xiaolu Pan, Issam Abu-Taha, Julia O. Reynolds, Hannah M. Campbell, Haihao Wang, Markus Kamler, Wilhelm Schmitz, Frank Ulrich Mueller, Na Li, Xiang Wei, Dao Wen Wang, Dobromir Dobrev, Xander H. T. Wehrens
Summary: Activation of the NFAT signaling pathway is seen in patients of Chinese and European descent, with NFATc2 knockout preventing the progression of AF in the CREM mouse model.
CARDIOVASCULAR RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tamara T. Haque, Pamela A. Frischmeyer-Guerrerio
Summary: This article discusses cytokines that regulate mast cell-mediated allergic immune responses. Understanding the mechanisms of these cytokines is important for the development of effective treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Mehtap Civelek, Sabrina Bilotta, Axel Lorentz
Summary: This review summarizes the anti-inflammatory effects of resveratrol on mast cell-mediated allergic reactions. The studies suggest that resveratrol can inhibit mast cell degranulation and the release of proinflammatory mediators, and has positive impacts on allergic rhinitis patients. However, strategies to improve resveratrol's bioavailability need to be developed.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Medicinal
Yuejin Wang, Shiting Hu, Baowen Dang, Yonghui Zhang, Guodong Zheng, Chenrui Zhao, Yihan Huang, Tao Zhang
Summary: This study found that silibinin has an anti-allergic effect in attenuating pseudo-allergic reactions in mice. It inhibits mast cell degranulation and calcium mobilization and prevents the release of cytokines and chemokines through the PLC gamma and PI3K/Akt signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jiajia Tong, Yan Li, Xiaojie Cai, Fangzhou Lou, Yang Sun, Zhikai Wang, Xichen Zheng, Hong Zhou, Ziyang Zhang, Zilong Fang, Wenxiang Ding, Siyu Deng, Zhenyao Xu, Xiaoyin Niu, Honglin Wang
Summary: In this study, the authors found that CKBA alleviates skin inflammation in atopic dermatitis (AD) by inhibiting mast cell activation and maintaining skin barrier homeostasis, through downregulating the extracellular signal-regulated kinase (ERK) signaling pathway. This suggests that CKBA could be a potential therapeutic candidate for AD.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nan Wang, Jue Wang, Yongjing Zhang, Yingnan Zeng, Shiling Hu, Haoyun Bai, Yajing Hou, Cheng Wang, Huaizhen He, Langchong He
Summary: The study revealed that IMP can reduce SP-induced calcium flux and suppress MC degranulation. IMP can alleviate SP-induced mouse PCA and ASA, and mitigate lung inflammation in an OVA-induced asthma model by inhibitiing MC activation in lung tissue. Additionally, IMP binds well to MRGPRX2 protein, suggesting it is a novel inhibitor for treating allergic asthma.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Ping Lin, Erica Scappini, Carlos Landaverde, Frederick Parekh-Glitsch, Charles J. Tucker, Gary R. Mirams, Anant B. Parekh
Summary: AKAP79 is a critical protein that organizes calcium signaling at the plasma membrane and maintains long-term signal transduction. It interacts with Orai1 channels and activates calcium nanodomains to stimulate calcineurin. This study finds that the interaction between AKAP79 and Orai1 is transient, and the recycling of inactive NFAT1 to AKAP79 in the plasma membrane helps maintain signal coupling.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Immunology
Irene Ridolfi, Luca Lo Sardo, Stefania Nicola, Richard Borrelli, Ludovica Comola, Valentina Marmora, Iuliana Badiu, Federica Corradi, Maria Carmen Rita Azzolina, Luisa Brussino
Summary: The vaccination rate is suboptimal in patients with ADs and PIDs. This project provides a dedicated structure for recommended vaccinations, achieving high adherence and safety. It proposes an effective model for managing vaccinations in frail patients in a specialist hospital setting.
Review
Immunology
Joanna Mackiewicz, Malwina Lisek, Tomasz Boczek
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline. It is associated with beta-amyloid plaques, tau tangles, and a sustained inflammatory response. The CaN/NFAT signaling pathway has been found to contribute to the progression of Alzheimer's disease and targeting this pathway may have therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
J. Matthew Meinig, Liqiang Fu, Blake R. Peterson
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Article
Chemistry, Multidisciplinary
David Hymel, Sutang Cai, Qi Sun, Rebecca S. Henkhaus, Chamani Perera, Blake R. Peterson
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Applied
Sahishna Phaniraj, Zhe Gao, Digamber Rane, Blake R. Peterson
Article
Microbiology
Jennifer R. Klaus, Jacqueline Deay, Benjamin Neuenswander, Wyatt Hursh, Zhe Gao, Tiffany Bouddhara, Todd D. Williams, Justin Douglas, Kyle Monize, Patricia Martins, Charlotte Majerczyk, Mohammad R. Seyedsayamdost, Blake R. Peterson, Mario Rivera, Josephine R. Chandler
JOURNAL OF BACTERIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kelsey E. Knewtson, Digamber Rane, Blake R. Peterson
ACS CHEMICAL BIOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Achala N. D. Punchi Hewage, Huili Yao, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Scott Lovell, Richard A. Bunce, Kate Eshelman, Sahishna M. Phaniraj, Molly M. Lee, Blake R. Peterson, Kevin P. Battaile, Allen B. Reitz, Mario Rivero
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Kelsey E. Knewtson, Chamani Perera, David Hymel, Zhe Gao, Molly M. Lee, Blake R. Peterson
Article
Biochemistry & Molecular Biology
Ruben De Coen, Lutz Nuhn, Chamani Perera, Maria Arista-Romero, Martijn D. P. Risseeuw, Alec Freyn, Raffael Nachbagauer, Lorenzo Albertazzi, Serge Van Calenbergh, David A. Spiegel, Blake R. Peterson, Bruno G. De Geest
Article
Microbiology
Saida Benomar, Patrick Lansdon, Aaron M. Bender, Blake R. Peterson, Josephine R. Chandler, Brian D. Ackley
Article
Biochemistry & Molecular Biology
Giuseppe Caruso, Cristina Benatti, Nicolo Musso, Claudia G. Fresta, Annamaria Fidilio, Giorgia Spampinato, Nicoletta Brunello, Claudio Bucolo, Filippo Drago, Susan M. Lunte, Blake R. Peterson, Fabio Tascedda, Filippo Caraci
Summary: The study showed that carnosine can protect macrophages from cell death and apoptosis induced by Aβ 1-42 oligomers, decrease oxidative stress, enhance macrophage phagocytic activity, and rescue fractalkine receptor CX3CR1. These new findings support the therapeutic potential of carnosine in the context of AD pathology, highlighting its multimodal mechanism of action.
Article
Chemistry, Medicinal
Erick J. Carlson, Himanshu Savardekar, Xiaojun Hu, Gabriella Lapurga, Courtney Johnson, Steven H. Sun, William E. Carson, Blake R. Peterson
Summary: Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells that expand dramatically in cancer patients, leading to immunosuppression. MDSCs mediate immunosuppression by producing peroxynitrite (PNT), which inactivates immune effector cells. A fluorescent sensor called PS3 allows direct detection of PNT, and using this method, it was found that cancer mice and melanoma patients have higher levels of PNT due to increased numbers of MDSCs. The kinase inhibitor dasatinib can block PNT production by inhibiting phagocytosis and reducing MDSC numbers.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zhe Gao, Krishna K. Sharma, Angelo E. Andres, Brandon Walls, Fadel Boumelhem, Zachary R. Woydziak, Blake R. Peterson
Summary: Fluorinated analogues of pyronin B, a fluorophore, were synthesized and shown to react reversibly with primary amines. These analogues undergo oxidation in the presence of proteins, yielding fluorescent pyronins, and this oxidation step can be enhanced by blue light irradiation. The fluorinated analogue 2,7-difluoropyronin B was found to localize in mitochondria in living HeLa cells and depolarize the mitochondria upon blue laser excitation. This photochemical control of mitochondrial biology is attributed to the enhanced cellular production of reactive oxygen species.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Molly M. Lee, Zhe Gao, Blake R. Peterson
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Multidisciplinary
Molly M. Lee, Blake R. Peterson
Article
Chemistry, Multidisciplinary
Thilanga N. Pahattuge, J. Matt Jackson, Rane Digamber, Harshani Wijerathne, Virginia Brown, Malgorzata A. Witek, Chamani Perera, Richard S. Givens, Blake R. Peterson, Steven A. Soper
CHEMICAL COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)