Article
Multidisciplinary Sciences
Zheng-Mei Xiong, Xiaojing Mao, Mason Trappio, Chanda Arya, Jasmin El Kordi, Kan Cao
Summary: Methylene blue, as a premier antioxidant, has shown potential as a sunscreen active ingredient for UV radiation protection. In comparison to oxybenzone, it exhibits better UVB absorption efficiency, prevents UVB-induced DNA damage, and does not harm coral reefs, suggesting its promise as a coral reef-friendly sunscreen active ingredient.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Cell Biology
Jake Atkinson, Eva Bezak, Ivan Kempson
Summary: DNA double-strand breaks play a fundamental role in cell biology, but there is a lack of a reliable assay for quantitatively visualizing DSBs. Relying on proxy detection methods can lead to misinterpretation of conventional assays, highlighting the need for the development of more accurate DSB detection methods.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Zheng-Yin Pan, Yu-Yi Ling, Hang Zhang, Liang Hao, Cai-Ping Tan, Zong-Wan Mao
Summary: This study reveals a novel Pt(IV) prodrug (DFX-Pt) with high activity against cisplatin-insensitive breast cancer cells, which degrades genes related to the DSB damage pathway by regulating RNA modification and reducing cellular free iron.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Svetlana V. Kostyuk, Elizaveta S. Ershova, Andrey V. Martynov, Andrey V. Artyushin, Lev N. Porokhovnik, Elena M. Malinovskaya, Elizaveta M. Jestkova, Natalia V. Zakharova, George P. Kostyuk, Vera L. Izhevskaia, Sergey I. Kutsev, Natalia N. Veiko
Summary: This study found that cfDNA extracted from the plasma of schizophrenic patients and healthy controls contains an oxidative DNA marker, 8-oxodG, and can stimulate an adaptive response in human cells. In vitro experiments showed that adding cfDNA from both groups to human cell cultures can induce the synthesis of free radicals and trigger various responses such as antioxidant, repair, and anti-apoptotic processes.
Article
Environmental Sciences
Ayumi Eguchi, Sayaka Mizukami, Misato Nakamura, Sousuke Masuda, Hirotada Murayama, Masashi Kawashima, Mari Inohana, Rei Nagahara, Mio Kobayashi, Risako Yamashita, Suzuka Uomoto, Emi Makino, Ryoichi Ohtsuka, Naofumi Takahashi, Shim-Mo Hayashi, Robert R. Maronpot, Makoto Shibutani, Toshinori Yoshida
Summary: The study suggests that MNZ may induce steatosis-related hepatocarcinogenesis in HFD-fed rats by inducing DNA double-strand breaks and modulating autophagy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Edward O'Neill, Michael Mosley, Bart Cornelissen
Summary: An effective absorbed dose response relationship has not yet been established for Lutetium-177 based radionuclide therapies. The inherent biological heterogeneity of neuroendocrine and prostate cancers may make it difficult to establish cohort-based dose-response relationships. Instead, an individual-based approach that monitors the dose-response within each tumor could provide a valuable metric for monitoring treatment efficacy.
Article
Engineering, Environmental
Yukako Komaki, Yuko Ibuki
Summary: The study found that DBAN inhibits the NER repair mechanism, leading to a blockage in the DNA damage signaling pathway, which could be one of its carcinogenic mechanisms.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
George Rasti, Maximilian Becker, Berta N. Vazquez, Maria Espinosa-Alcantud, Irene Fernandez-Duran, Andres Gamez-Garcia, Alessandro Ianni, Jessica Gonzalez, Laia Bosch-Presegue, Anna Marazuela-Duque, Anna Guitart-Solanes, Sandra Segura-Bayona, Joan-Josep Bech-Serra, Michael Scher, Lourdes Serrano, Uma Shankavaram, Hediye Erdjument-Bromage, Paul Tempst, Danny Reinberg, Mireia Olivella, Travis H. Stracker, Carolina de la Torre, Alejandro Vaquero
Summary: SIRT1 plays a crucial role in regulating the DNA damage response by interacting with the PP4 phosphatase complex to control the signaling of DNA damage and repair.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Zhi-Feng Miao, Jing-Xu Sun, Mahliyah Adkins-Threats, Min-Jiao Pang, Jun-Hua Zhao, Xin Wang, Kai-Wen Tang, Zhen-Ning Wang, Jason C. Mills
Summary: The study reveals that high expression of DDIT4 in gastric chief cells decreases as cells become metaplastic. DDIT4 deficiency leads to increased mTORC1 levels, exacerbating mitosis of metaplastic cells and tumor formation.
Article
Biochemistry & Molecular Biology
Barbara de la Pena Avalos, Nicolas Paquet, Romain Tropee, Yan Coulombe, Hannah Palacios, Justin W. Leung, Jean-Yves Masson, Pascal H. G. Duijf, Eloise Dray
Summary: Efficient DNA repair and limitation of genome rearrangements depend on the crosstalk between different DNA double-strand break (DSB) repair pathways and their synchronization with the cell cycle. This study identifies EYA4 as a protein phosphatase that dephosphorylates RAD51, a key player in homologous recombination (HR) at DSBs. EYA4 regulates RAD51 localization, filament formation, foci formation, and activity through its tyrosine phosphatase activity. The findings have implications for understanding the pathological version of RAD51 in EYA4-overexpressing cancers.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Masaru Sasaki, Norikatsu Miyoshi, Shiki Fujino, Kazuhiro Saso, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Hirofumi Yamamoto, Chu Matsuda, Masayoshi Yasui, Masayuki Ohue, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: High expression of STAG3 is associated with poor prognosis in colorectal cancer, while knockdown of STAG3 inhibits cell migration and increases drug sensitivity. Particularly in BRAF-mutant CRC cells, silencing of STAG3 suppresses the expression of specific genes. STAG3 may serve as a potential prognostic marker and therapeutic target for CRC.
Article
Biochemistry & Molecular Biology
J. P. Jose Merlin, Graham Dellaire, Kieran Murphy, H. P. Vasantha Rupasinghe
Summary: Lung cancer has the highest mortality rate globally and is often diagnosed at late stages, necessitating genotoxic chemotherapy. Cancer prevention, including the use of antioxidants, is a major focus. The study found that an antioxidant formulation has the potential to reduce DNA damage, showing promise as a chemoprotectant by attenuating activation of kinase following carcinogen exposure.
Article
Biochemistry & Molecular Biology
Yan Zhang, Hao Gong, Ji-Shuai Wang, Meng-Na Li, De-Li Cao, Jun Gu, Lin-Xia Zhao, Xin-Dan Zhang, Yu-Tao Deng, Fu-Lu Dong, Yong-Jing Gao, Wen-Xing Sun, Bao-Chun Jiang
Summary: In neuropathic pain, the expression of ?H2AX and ATM is downregulated. Inhibiting ATM with KU55933 can reduce the level of ?H2AX and induce mechanical allodynia and thermal hyperalgesia. Further studies show that inhibiting ATM can upregulate ERK phosphorylation and downregulate potassium ion channel genes, increasing sensory neuron excitability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Sijing Xiong, Susi Tan, Peng Huang, Yao Li, Joo Eun Chung, Motoichi Kurisawa, Daniele Zink, Jackie Y. Y. Ying
Summary: Nanoscale systems for anticancer drug delivery can reduce toxicity towards non-tumor cells. Micellar nanocomplexes (MNCs) comprising green tea catechin derivatives have been developed for efficient delivery of anticancer proteins. MNCs showed potent cytotoxicity against breast cancer cells, regardless of HER2/neu expression levels, while they were not toxic for normal human cells. These findings suggest that green tea catechin derivative-based MNCs could improve the efficacy and safety of therapies with anticancer proteins.
BIOMATERIALS SCIENCE
(2023)
Article
Oncology
Shilong Liu, Ning Zhan, Chunzi Gao, Piao Xu, Hong Wang, Siyu Wang, Shiqi Piao, Suwei Jing
Summary: CBR3-AS1 plays a role in promoting tumorigenesis and reducing radiosensitivity in non-small cell lung cancer, possibly through regulating the miR-409-3p/SOD1 pathway.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
