期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 41, 期 1, 页码 66-71出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2008.08.036
关键词
Transpeptidation; Reverse proteolysis; Antigen processing; Protease; Antigen splicing
Reverse proteolysis and transpeptidation lead to the generation of polypeptide sequences that cannot be inferred directly from genome sequences as they are post-translational phenomena. These phenomena have so Far received little attention although the physiological consequences may reach far The protease-mediated synthesis of several immunodominant MHC class I antigens was recently reported, Underscoring its importance to immunity. Reverse proteolytic and transpeptidation mechanisms as well as conditions that favor successful protease-catalyzed synthetic events are discussed here. (C) 2008 Elsevier Ltd. All rights reserved.
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