Article
Biochemistry & Molecular Biology
Kwan Long Mung, Annika Meinander, Paivi J. Koskinen
Summary: LDHA is an important enzyme in glycolysis, and it can be phosphorylated by PIM kinases at serine 161. Phosphorylation suppresses the degradation of nuclear LDHA and promotes its interaction with 14-3-3 proteins. PIM kinases support the expression and function of nuclear LDHA through phosphorylation-dependent interactions.
Article
Cardiac & Cardiovascular Systems
Ting-Ting Zhang, Qing-Qing Lei, Jie He, Xin Guan, Xin Zhang, Ying Huang, Zi-Yue Zhou, Rui-Xin Fan, Ting Wang, Chen-Xi Li, Jin-Yan Shang, Zhuo-Miao Lin, Wan-Li Peng, Li-Kai Xia, Yu-Ling He, Chuan-Ying Hong, Jing-Song Ou, Rui-Ping Pang, Xiao-Ping Fan, Hui Huang, Jia-Guo Zhou
Summary: This study reveals that Best3 mutation, which mainly acts in blood vessels, leads to aortic dissection by regulating the degradation of MEKK2/3, controlling smooth muscle cell phenotypic switch, and maintaining the structural integrity of the aorta. This provides a new therapeutic target for the treatment of aortic dissection.
Review
Pharmacology & Pharmacy
Yifan Chen, Xuejing Shao, Ji Cao, Hong Zhu, Bo Yang, Qiaojun He, Meidan Ying
Summary: The crosstalk between phosphorylation and ubiquitination plays a crucial role in tumorigenesis, providing new directions and strategies for tumor therapy.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Oncology
Xueyan Shi, Sichuang Tan, Sipin Tan
Summary: The NLRP3 inflammasome plays a crucial role in sepsis by promoting immune defense and inflammatory responses through its activation pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Na Zhou, Hailong Qi, Junjun Liu, Guangze Zhang, Jianping Liu, Ning Liu, Minglu Zhu, Xuyang Zhao, Chang Song, Zhe Zhou, Jingjing Gong, Ridong Li, Xinyu Bai, Yan Jin, Yongfeng Song, Yuxin Yin
Summary: The OTUD3 c.863G>A mutation is associated with obesity and a higher risk of diabetes. OTUD3 is an important regulator of energy metabolism, involved in the regulation of glucose and lipid metabolism.
Article
Multidisciplinary Sciences
Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao, Xin Lin
Summary: The phosphorylation of RIPK1 at tyrosine residue is crucial for regulating cell death and inflammation, and its dysregulation can lead to systemic inflammation and disturbed hematopoiesis.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Yixin Zhang, Peilan Zhou, Fengfeng Lu, Ruibin Su, Zehui Gong
Summary: Overexpression of A20-binding inhibitor of nuclear factor-kappa B (ABIN-1) attenuated morphine tolerance and dependence in mice, likely through facilitating beta-arrestin2 degradation. ABIN-1 targeted beta-arrestin2 to regulate morphine tolerance, suggesting it as a potential therapeutic target for alleviating morphine tolerance and dependence.
MOLECULAR PHARMACOLOGY
(2021)
Article
Oncology
Huijuan Liu, Jiahuan Yang, Yang Zhang, Jingxia Han, Yuyan Yang, Zihan Zhao, Xintong Dai, Hongqi Wang, Xiujuan Ding, Yanrong Liu, Weilong Zhong, Wenqing Gao, Tao Sun
Summary: This study confirmed the impact of psychological stress on tumor progression and identified DRD2 as a potential mediator of stress-induced malignant tumor progression. The results suggest that DRD2 regulation of HIF1 alpha may play a key role in this process, and DRD2 inhibition with TFP could be a promising therapeutic strategy for managing stress in cancer patients.
Article
Multidisciplinary Sciences
Olena Zhulyn, Hannah D. D. Rosenblatt, Leila Shokat, Shizhong Dai, Duygu Kuzuoglu-Ozturk, Zijian Zhang, Davide Ruggero, Kevan M. M. Shokat, Maria Barna
Summary: An outstanding mystery in biology is why some species can regenerate tissues whereas mammals cannot. This study found that rapid activation of protein synthesis is a unique feature of limb regeneration in the axolotl. The mTORC1 pathway was identified as a key signal that mediates tissue regeneration and translational control in the axolotl.
Article
Cell Biology
Sohail Jahid, Jose A. Ortega, Linh M. Vuong, Isabella Maria Acquistapace, Stephanie J. Hachey, Jessica L. Flesher, Maria Antonietta La Serra, Nicoletta Brindani, Giuseppina La Sala, Jacopo Manigrasso, Jose M. Arencibia, Sine Mandrup Bertozzi, Maria Summa, Rosalia Bertorelli, Andrea Armirotti, Rongsheng Jin, Zheng Liu, Chi-Fen Chen, Robert Edwards, Christopher C. W. Hughes, Marco De Vivo, Anand K. Ganesan
Summary: CDC42 family GTPases control tumor cell invasion and angiogenesis, and a new drug called ARN22089 has been discovered to inhibit tumor growth and angiogenesis by modulating CDC42 signaling.
Editorial Material
Hematology
Monika Haemmerle
Summary: This study explores the role of Mnk1 in megakaryocytes and platelets, showing that it regulates protein synthesis and affects megakaryocyte ploidy and platelet production. These findings have clinical implications and contribute to our understanding of platelet function and thrombosis.
Article
Multidisciplinary Sciences
Zunyong Liu, Shuguo Hou, Olivier Rodrigues, Ping Wang, Dexian Luo, Shintaro Munemasa, Jiaxin Lei, Jun Liu, Fausto Andres Ortiz-Morea, Xin Wang, Kinya Nomura, Chuanchun Yin, Hongbo Wang, Wei Zhang, Keyan Zhu-Salzman, Sheng Yang He, Ping He, Libo Shan
Summary: Stomatal reopening in plants is dynamically regulated by the interaction between secreted peptides SCREWs and the receptor kinase NUT. This system counter-regulates the closure of stomata induced by abscisic acid and microbe-associated molecular patterns. SCREWs trigger the phosphorylation of key proteins involved in stomatal closure, leading to increased activity of kinase OST1 and reduced activity of anion channels. The SCREW-NUT system plays an important role in preventing uncontrolled stomatal closure and optimizing plant fitness.
Article
Biochemistry & Molecular Biology
Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook
Summary: Innate or acquired resistance to BRAF or MEK1/2 inhibitors often results in sustained or reinstated activation of ERK1/2. To overcome this, ERK1/2 inhibitors have been developed that can inhibit catalytic activity or prevent activation of ERK1/2. In this study, it was found that multiple ERK inhibitors can drive turnover of ERK2, the most abundant isoform, without affecting ERK1. This turnover is caused by ERKi binding to ERK2 and can be prevented by MEKi pre-treatment. ERKi treatment leads to ubiquitination and proteasome-dependent degradation of ERK2. These findings suggest that ERKi act as "kinase degraders" and may have implications for the therapeutic use of ERKi.
BIOCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yuluo Rong, Jin Fan, Chengyue Ji, Zhuanghui Wang, Xuhui Ge, Jiaxing Wang, Wu Ye, Guoyong Yin, Weihua Cai, Wei Liu
Summary: This study reveals the involvement of ferroptosis in spinal cord ischemia-reperfusion injury (SCIRI) and the key role of USP11 in regulating ferroptosis, as well as promoting autophagy activation. Targeting USP11-mediated autophagy-dependent ferroptosis could be a promising approach for the treatment of SCIRI.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhang, Xiao-Tong Lin, Hong-Qiang Yu, Lei Fang, Di Wu, Yuan-Deng Luo, Yu-Jun Zhang, Chuan-Ming Xie
Summary: FBXL6 is a key driver of hepatocellular carcinoma metastasis, promoting immune evasion and tumor spread through the activation of TKT. Targeting TKT effectively blocks FBXL6-driven tumor spread, offering a new approach for treating advanced liver cancer.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)