期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 41, 期 10, 页码 1972-1976出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2009.05.013
关键词
Miro; Milton; Mitochondria; Motility; Fusion; Fission; Kinesin; Microtubule; Calcium; Pink1; OGT
资金
- NIH [DK51526]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R29DK051526, R01DK051526] Funding Source: NIH RePORTER
Calcium oscillations control mitochondrial motility along the microtubules and in turn, support on-demand distribution of mitochondria. However, the mechanism mediating the Ca2+ effect remained a mystery. Recently, several papers reported on the Ca2+-dependent regulation of mitochondrial dynamics by a Miro-Milton complex linking mitochondria to kinesin motors. Both mitochondrial motility and fusion-fission dynamics seem to be sensitive to a Ca2+-dependent switch by this complex. Evidence is emerging that calcium signaling through Miro-Milton is central to coordination of the local oxidative metabolism with the energy demands and protection against Ca2+-induced cell injury. (C) 2009 Elsevier Ltd. All rights reserved.
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