Article
Gastroenterology & Hepatology
Yonglong Zhang, Hui Wang, Tao Chen, Haolu Wang, Xiaowen Liang, Yuchen Zhang, Jinlin Duan, Shenjiao Qian, Ke Qiao, Lei Zhang, Yanfeng Liu, Jian Wang
Summary: This study revealed aberrant ceramide biosynthesis in GBC tissues and identified C24-Ceramide as a potential diagnostic biomarker for GBC patients. Additionally, it proposed a potential therapeutic intervention for GBC through competition with C24-Ceramide via PIP4K2C.
Article
Cardiac & Cardiovascular Systems
Weijing Yun, Lei Qian, Ruqiang Yuan, Hu Xu
Summary: Periplocymarin has a protective effect on DOX-induced cardiomyopathy by reducing cardiomyocyte apoptosis and improving cardiac function, thereby mitigating DOX-induced cardiotoxicity. Experimental results and analysis demonstrated that periplocymarin significantly regulates DOX-induced cardiomyocyte apoptosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Daniel Canals, Silvia Salamone, Bruno Jaime Santacreu, Daniel Aguilar, Maria Jose Hernandez-Corbacho, Anne G. Ostermeyer-Fay, Meaghan Greene, Erika Nemeth, John D. Haley, Lina M. Obeid, Yusuf A. Hannun
Summary: The study revealed that low doses of the chemotherapeutic compound doxorubicin result in dysregulation of cytoskeletal proteins, enhancing cancer cell migration, which could explain the reported effects of doxorubicin worsening cancer metastasis in animal models.
Article
Multidisciplinary Sciences
Vinu Krishnan, Kevin Peng, Apoorva Sarode, Supriya Prakash, Zongmin Zhao, Sergey K. Filippov, Kristina Todorova, Brittney R. Sell, Omar Lujano, Shirin Bakre, Anusha Pusuluri, Douglas Vogus, Kenneth Y. Tsai, Anna Mandinova, Samir Mitragotri
Summary: DOCTOR is a novel topical treatment for skin cancer that demonstrates high cancer-cell killing specificity and superior safety to healthy skin cells compared to conventional treatments. In vivo and ex vivo studies confirm its efficacy in treating cancerous lesions without irritation or systemic absorption, making it a safe and potent option for clinical use.
Review
Oncology
Megan Sheridan, Besim Ogretmen
Summary: Sphingolipids are membrane-associated lipids that play crucial roles in regulating cell functions such as proliferation, migration, senescence, and death. In cancer cells, sphingolipids are involved in pathways relevant to cancer therapy, including invasion, metastasis, apoptosis, and lethal mitophagy. Notable sphingolipids like ceramide and sphingosine-1 phosphate have contrasting effects on cell survival and chemotherapeutic resistance, with ceramide inducing death and lethal mitophagy, and sphingosine-1 phosphate promoting survival. These lipids are characterized by a long-chain sphingosine backbone linked to a fatty acyl chain with variable length, and alterations in ceramide synthases and sphingolipid regulation of mitophagy have important implications for cancer therapy.
Article
Environmental Sciences
Reza Safavi, Hossein Soltanzadeh, Zahra Hojati
Summary: This study aimed to enhance the therapeutic efficacy of Dox by co-administration of Scr in gastric cancer treatment. The results showed that Scr-Dox combination therapy exerted stronger anti-cancer effects on AGS and MKN28 cell lines, significantly reducing cell proliferation, invasion, and migration, increasing apoptosis rate, and modulating the expression of apoptosis- and metastasis-related genes. In conclusion, Scr-Dox combination therapy is more effective in the treatment of gastric cancer compared to Scr and Dox monotherapy.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mahsa Shahriari, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani, Mona Alibolandi
Summary: The study synthesized an amphiphilic copolymer, self-assembled into polymersomes for targeted co-encapsulation of DOX and CPT, demonstrating sustained release and synergistic cytotoxicity against cancer cells. Aptamer conjugation further enhanced cytotoxicity and tumor-specific accumulation in vivo, suggesting a promising combinatorial delivery platform for non-small cell lung cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Karolina Kowalska, Dominika Ewa Habrowska-Gorczynska, Dominika Kurczewska, Kamila Dominska, Kinga Anna Urbanek, Agnieszka Wanda Piastowska-Ciesielska
Summary: Methylsulfonylmethane (MSM) may have a beneficial effect in endometrial cancer treatment, increasing cell sensitivity to chemotherapy drugs by regulating specific protein kinase pathways.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mei-Yi Lin, Wan-Ting Cheng, Hui-Ching Cheng, Wan-Ching Chou, Hsiu- Chen, Hsiu-Chung Ou, Kun-Ling Tsai
Summary: Baicalin can enhance chemosensitivity to doxorubicin in breast cancer cells through inducing apoptosis via increasing intracellular ROS and Ca2+ concentrations. Pretreatment with ROS inhibitor or Ca2+ chelator can reduce this chemosensitivity.
Article
Pharmacology & Pharmacy
Jiacui Xie, He Wang, Qiudi Huang, Jiachang Lin, Huaying Wen, Yingling Miao, Le Lv, Dongxue Ruan, Xiyong Yu, Linghao Qin, Yi Zhou
Summary: In this study, a prodrug camptothecin-triphenylphosphine modified with hyaluronic acid was used to deliver the drug into mitochondria, leading to disruption of mitochondrial structure and function, increased apoptosis of lung cancer cells, and inhibition of tumor growth.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Cell Biology
MelissaR Pitman, Martin K. Oehler, Stuart M. Pitson
Summary: Ovarian cancer is a deadly gynaecological malignancy commonly diagnosed at an advanced stage, making treatment challenging. Novel strategies for early detection and therapeutics are urgently needed to improve patient survival, with the sphingolipid pathway showing promise as a potential therapeutic target against chemotherapy-resistant disease.
CELLULAR SIGNALLING
(2021)
Article
Engineering, Biomedical
Simzar Hosseinzadeh, Hojjatollah Nazari, Elaheh Esmaeili, Shadie Hatamie
Summary: Curcumin nanoparticles modified by PEG were successfully developed and showed promising anticancer effects, especially for the treatment of thyroid cancer. The nanoparticles exhibited high efficiency and stability, as confirmed by various evaluation parameters and experimental data.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Chemistry, Medicinal
Guorui Zhang, Ruijuan Yin, Xiufei Dai, Guanzhao Wu, Xin Qi, Jing Li, Tao Jiang
Summary: This study presents a series of novel FL118 derivatives with significant anti-tumor activity and drug resistance, particularly against small-cell lung cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Feng Xu, Tian Xia, Qi-Tong Xu, Xu Zhang, Yu-Zhou Huang, Xi Sun, Liang Shi, Xu-Jie Zhou, Ji-Fu Wei, Qiang Ding
Summary: Chemoresistance, which is closely associated with therapeutic outcomes and prognosis in breast cancer patients, has been shown to be influenced by RNA binding proteins (RBPs) such as RBMS2. In this study, the researchers found that upregulation of RBMS2 enhanced sensitivity to doxorubicin and induced apoptosis in breast cancer cells. Furthermore, the chemosensitizing effect of RBMS2 was found to be mediated by the regulation of the Bcl-2 modifying factor (BMF). These findings suggest that RBMS2 may serve as a potential therapeutic target for drug-resistant breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Won Seok Lee, Eun Ho Kim
Summary: This study investigated the effectiveness of TTFields in inhibiting lung cancer growth and metastasis, as well as the therapeutic effectiveness of TTFields alongside radiation and chemosensitivity-enhancing agents. The results showed that TTFields can inhibit lung cancer cell growth and migration, improve chemosensitivity, and have the potential to improve patient outcomes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Hematology
Albin Jeanne, Thomas Sarazin, Magalie Charle, Charlotte Kawecki, Alexandre Kauskot, Tobias Hedtke, Christian E. H. Schmelzer, Laurent Martiny, Pascal Maurice, Stephane Dedieu
Summary: The study shows that the TAX2 peptide can significantly reduce platelet aggregation and interaction with collagen, and delay arterial thrombus formation, representing a potential antithrombotic agent.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Oncology
Camille Fuselier, Sandrine Quemener, Eleonore Dufay, Camille Bour, Camille Boulagnon-Rombi, Nicole Bouland, El-Hadi Djermoune, Jerome Devy, Laurent Martiny, Christophe Schneider
Summary: Melanoma, the most aggressive form of skin cancer, relies heavily on angiogenesis for progression. Low-diluted Phenacetinum shows promising anti-tumoral effects in inhibiting melanoma growth and metastasis through regulating blood vessel formation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Olivier Bocquet, Amandine Wahart, Thomas Sarazin, Elise Vincent, Christophe Schneider, Anne Fougerat, Stephanie Gayral, Auberi Henry, Sebastien Blaise, Beatrice Romier-Crouzet, Camille Boulagnon, Stephane Jaisson, Philippe Gillery, Amar Bennasroune, Herve Sartelet, Muriel Laffargue, Laurent Martiny, Laurent Duca, Pascal Maurice
Summary: Desialylation plays a crucial role in various human disorders, and inhibiting neuraminidases may be beneficial for managing atherosclerosis. Oseltamivir phosphate shows promising effects in human cancer cells, inflammation, and insulin resistance, but has limited benefits on atherosclerosis and thrombosis.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Oncology
Albin Jeanne, Thomas Sarazin, Magalie Charle, Catherine Moali, Caroline Fichel, Camille Boulagnon-Rombi, Maite Callewaert, Marie-Christine Andry, Eric Diesis, Frederic Delolme, Damien Rioult, Stephane Dedieu
Summary: Ovarian cancer prognosis is poor with high recurrence rates, necessitating new therapeutic targets. Thrombospondin-1 (TSP-1) interacts with CD47 receptor to inhibit immunity, and TAX2 is the first selective orthosteric antagonist for this interaction. TAX2 modulates the tumor microenvironment and activates anti-tumor immune responses, showing promise as an anti-cancer therapy.
Article
Oncology
Kaouther Ben Arfi, Christophe Schneider, Amar Bennasroune, Nicole Bouland, Aurore Wolak-Thierry, Guillaume Collin, Cuong Cao Le, Kevin Toussaint, Cathy Hachet, Veronique Lehrter, Stephane Dedieu, Olivier Bouche, Hamid Morjani, Camille Boulagnon-Rombi, Aline Appert-Collin
Summary: This study found that high expression of DDR1 is associated with worse event-free survival in CRC patients, and it may play a role in the invasive properties of colon adenocarcinoma.
Article
Cell Biology
Elisabete Cruz Da Silva, Laurence Choulier, Jessica Thevenard-Devy, Christophe Schneider, Philippe Carl, Philippe Ronde, Stephane Dedieu, Maxime Lehmann
Summary: EGFR, a therapeutic target in GBM, is closely regulated by endocytosis proteins, indicating a potential therapeutic target for improving GBM treatment.
Article
Biochemistry & Molecular Biology
Oceane Campion, Jessica Thevenard Devy, Clotilde Billottet, Christophe Schneider, Nicolas Etique, Jean-William Dupuy, Anne-Aurelie Raymond, Camille Boulagnon Rombi, Marie Meunier, El-Hadi Djermoune, Elodie Lelievre, Amandine Wahart, Camille Bour, Cathy Hachet, Stefano Cairo, Andreas Bikfalvi, Stephane Dedieu, Jerome Devy
Summary: The inhibition of LRP-1 in MDA-MB-231 tumors led to a 60% growth delay due to morphological and functional vascular differences, confirmed by angiogenic models. In vitro, the secretome of LRP-1-repressed cells restrained HUVECs' angiogenic capabilities. Proteomic analysis revealed that LRP-1 supports tumor growth and angiogenesis through regulation of TGF-beta signaling and the plasminogen/plasmin system.
Article
Pharmacology & Pharmacy
Claudia Herrera-Leon, Francisco Ramos-Martin, Hassan El Btaouri, Viviane Antonietti, Pascal Sonnet, Laurent Martiny, Fabrizia Zevolini, Chiara Falciani, Catherine Sarazin, Nicola D'Amelio
Summary: This study demonstrates that specific arrangements of amino acids in anticancer peptides significantly impact their activity, with changes in amino acid order or substitutions in key motifs affecting the efficacy against cancer cell lines. The study also reveals that the insertion capability in cancer-mimicking membranes is crucial for the activity of the peptides, with specific amino acids playing a role in anchoring and insertion into these membranes.
Article
Oncology
Benoit Langlois, Julie Martin, Christophe Schneider, Cathy Hachet, Christine Terryn, Damien Rioult, Laurent Martiny, Louis Theret, Stephanie Salesse, Stephane Dedieu
Summary: LRP1 regulates the invasion ability of thyroid carcinoma cells by downregulating calpain activity and transcriptional expression. It inhibits calpain activity through PKA-dependent phosphorylation and affects cell adhesion and β1 integrin expression. This study reveals the pro-motile action of LRP1 in thyroid cancer cells and highlights a novel facet of its de-adhesion receptor status.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Iheb Toumi, Sonia Yatouji, Nicolas Borie, Simon Remy, Jean-Hugues Renault, Lise Chazee, Mohamed Hammami, Laurent Martiny, Emmanuelle Devarenne-Charpentier, Hassan El Btaouri
Summary: This study evaluated the anti-tumoral activities of Thymelaea hirsuta L. extracts and their adjuvant potential in conventional colorectal cancer therapy. The ethyl acetate fraction induced cell cycle arrest and apoptosis, inhibited cell invasion, and potentiated colorectal cancer cells to 5-FU treatment.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Aicha Sassi, Maxime Fredon, Alexia K. Cotte, Camille Fuselier, Christophe Schneider, Laurent Martiny, David Monchaud, Leila Chekir-Ghedira, Virginie Aires, Dominique Delmas
Summary: Despite progress in treatments, melanoma incidence and mortality have increased. Chrysin, a natural polyphenol, shows potential as a therapeutic strategy due to its modulation of tumorigenesis and resistance mechanisms. This study reveals a link between chrysin-induced antitumoral effects, DNA damage pathway activation, and reduced angiogenesis in melanoma cells. The disruption of key protein actors in tumor growth by chrysin suggests its potential as a new therapeutic strategy in melanoma treatment.
Article
Multidisciplinary Sciences
Aubery Henry, Marine Mauperin, Jerome Devy, Stephane Dedieu, Lise Chazee, Cathy Hachet, Christine Terryn, Laurent Duca, Laurent Martiny, Emmanuelle Devarenne-Charpentier, Hassan El Btaouri
Summary: Multidrug resistance (MDR) is a common challenge in cancer chemotherapy, and it is often caused by the overexpression of membrane transport proteins such as P-gp. This study investigated the involvement of LRP-1 in the expression and subcellular redistribution of P-gp, and its potential role in P-gp-mediated MDR. The results showed that LRP-1 blockade reduced lysosomes density and the levels of LAMP-1 and P-gp, leading to the restoration of drug sensitivity in MDR cells.
Article
Biochemistry & Molecular Biology
Anne-Florence Blandin, Elisabete Cruz Da Silva, Marie-Cecile Mercier, Oleksandr Glushonkov, Pascal Didier, Stephane Dedieu, Cristophe Schneider, Jessica Devy, Nelly Etienne-Selloum, Monique Dontenwill, Laurence Choulier, Maxime Lehmann
Summary: The study showed that EGFR TKIs induce increased EGFR accumulation in early endosomes in GBM cells, potentially altering the response of glioma cells to therapeutic treatment. Depletion of integrins can also affect the sensitivity of glioma cells to tyrosine kinase inhibitors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)