Article
Oncology
Chang-Long Chen, Hua-Qian Mo, Yan-Hui Jiang, Xiao-Hui Zhao, Shuang Ma, Kai-Yun You, Yue Pan, Yi-Min Liu
Summary: BRD7 exerts anti-tumor effects in HCC by transcriptionally activating the p53 pathway. Changes in BRD7 and p53 expression can affect tumor cell functions and growth. Additionally, BRD7 may positively regulate activation of the p53 pathway.
Article
Oncology
Tao Ma, Daoyuan Wang, Jiajun Wu, Yihui Xiao, Anfang Fan, Xiaocheng Cao, Jianguo Cao, Kaiqun Ren
Summary: This study found that KCTD10 can suppress the development and carcinogenicity of hepatocellular carcinoma (HCC) cells through regulating the Notch signaling pathway. Down-regulation of KCTD10 in HCC cells increased the expression of cancer stem cell markers, promoted self-renewal and tumorigenic ability, and increased the population of CD133+ cells. Further molecular studies revealed that the decrease in the transmembrane/intracellular region (NTM) of Notch1 and the regulation of the balance between P53 and Notch activity were involved in the mechanism.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Rui Peng, Jun Cao, Bing-Bing Su, Xue-song Bai, Xin Jin, Ao-qing Wang, Qian Wang, Ren-jie Liu, Guo-qing Jiang, Sheng-jie Jin, Chi Zhang, Dou-sheng Bai
Summary: In this study, we discovered that circPTTG1IP, a circular RNA, acts as a tumor suppressor in hepatocellular carcinoma (HCC). Low expression of circPTTG1IP is associated with poor prognosis in HCC patients. Mechanistically, circPTTG1IP functions as a competing endogenous RNA (ceRNA) of RNF125 by binding miR-16-5p, thereby increasing the level of E3 ubiquitin ligase RNF125 and promoting the degradation of JAK1 protein. Filgotinib, a JAK1 inhibitor, can restrict HCC progression induced by low circPTTG1IP expression.
Article
Oncology
Rui Shi, Zirong Liu
Summary: RPL15 plays crucial roles in the progression and metastasis of hepatocellular carcinoma (HCC), serving as a promising candidate for targeted therapies.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kajal Chakraborty, Prima Francis
Summary: The study evaluated the activation of p53 and p27 pathways for attenuating hepatocellular carcinoma. A novel compound, hyrtiosone A, isolated from a marine demosponge, exhibited potential anti-inflammatory and antioxidant properties, making it a promising candidate for liver cancer treatment. The compound showed in vitro anticancer activity in HepG2 cells by inducing apoptosis and cell cycle arrest, and upregulating p53 and p27 gene expression.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Xuxiao Chen, Ao Huang, Yupeng Wang, Feiyu Chen, Bo Hu, Xin Zhang, Yunfan Sun, Jian Wang, Jianwen Cheng, Pengxiang Wang, Yuan Ji, Shuangjian Qiu, Jia Fan, Jian Zhou, Xinrong Yang
Summary: BAP1 and its mutations have been shown to play critical roles in tumor biology, particularly in hepatocellular carcinoma (HCC). This study found that mutations and downregulation of BAP1 were associated with aggressive tumor phenotypes in HCC, while wild-type BAP1 inhibited HCC cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) by stabilizing PTEN through deubiquitination. These findings suggest that BAP1 acts as a tumor suppressor in HCC by regulating PTEN and EMT.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Letter
Oncology
Shuangshuang Yin, Wenke Jin, Yuling Qiu, Leilei Fu, Tao Wang, Haiyang Yu
Summary: This study demonstrates that solamargine (SM) inhibits the proliferation of hepatocellular carcinoma (HCC) and induces HCC cell apoptosis and autophagy in vitro and in vivo. It exerts its anti-tumor effects through the LIF/miR-192-5p/CYR61/Akt signaling pathways and also affects tumor-associated macrophages and other immune cell populations in the HCC microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Liping Tang, Shasha Zhu, Weiyan Peng, Xuedong Yin, Cui Tan, Yaying Yang
Summary: The protein expression of MAPK10 is significantly downregulated in HCC patients compared to normal tissues, and its negative expression is correlated with advanced tumor stage, more microsatellite nodules, higher serum AFP, and shorter overall survival time in HCC patients. MAPK10 is frequently methylated in HCC, and its methylation is associated with silenced or downregulated expression.
Article
Medicine, Research & Experimental
Katherine E. Redd Bowman, Lisa Ahne, Liam O'Brien, Erica R. Vander Mause, Phong Lu, Bryce Wallis, Kimberley J. Evason, Carol S. Lim
Summary: Due to the limited curative treatments and high death rate of hepatocellular carcinoma (HCC), there is a need for new therapies. This study explores the potential of re-engineering p53 through fusion with the pro-apoptotic BH3 protein Bad, leading to the development of p53-Bad* as a novel HCC therapeutic. The results demonstrate that p53-Bad* can effectively target mitochondria in liver cancer cell lines, exhibit superior apoptotic activity compared to wild-type p53, and reduce tumor burden in a zebrafish HCC model.
MOLECULAR PHARMACEUTICS
(2023)
Article
Oncology
Lei Bi, Yidan Ren, Maoxiao Feng, Peng Meng, Qin Wang, Weiping Chen, Qinlian Jiao, Yuli Wang, Lutao Du, Fuqiong Zhou, Yucui Jiang, Feiyan Chen, Chuanxin Wang, Bo Tang, Yunshan Wang
Summary: The study reveals that HDAC11 is highly expressed in HCC and its loss can reduce hepatocellular tumorigenesis and prolong survival. Loss of HDAC11 promotes histone acetylation in the promoter of LKB1 gene, activating the AMPK signaling pathway to inhibit glycolysis and suppress cancer stemness and HCC progression.
Article
Biochemistry & Molecular Biology
Dong Ma, Pengpeng Liu, Junjun Wen, Yang Gu, Zhangshuo Yang, Jianwei Lan, Haining Fan, Zhisu Liu, Deliang Guo
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide, and current treatment strategies have limited effectiveness. This study identified Ficolin-3 (FCN3) as a potential prognostic factor for HCC, with decreased expression associated with poor prognosis. Overexpression of FCN3 was found to induce apoptosis and inhibit cell proliferation through the p53 signaling pathway. Furthermore, FCN3 was shown to modulate nuclear translocation of EIF6 by binding to SBDS, leading to ribosomal stress and activation of the p53 pathway. Y-Box Binding Protein 1 (YBX1) was also found to regulate FCN3 and SBDS at the transcription and translation level. Additionally, a negative feedback loop involving p53, YBX1, and SBDS was identified downstream of FCN3.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dong Ma, Pengpeng Liu, Junjun Wen, Yang Gu, Zhangshuo Yang, Jianwei Lan, Haining Fan, Zhisu Liu, Deliang Guo
Summary: Hepatocellular carcinoma (HCC) is the third-leading cause of cancer deaths globally. Downregulation of Ficolin-3 (FCN3) protein in HCC tissues is closely related to poor prognosis. Overexpression of FCN3 induces apoptosis and inhibits cell proliferation via the p53 signaling pathway. FCN3 modulates the nuclear translocation of eukaryotic initiation factor 6 (EIF6) by binding ribosome maturation factor (SBDS) to induce ribosomal stress and activation of the p53 pathway. Y-Box Binding Protein 1 (YBX1) is involved in the transcription and translation level regulation of FCN3 to SBDS. A negative feedback loop involving p53, YBX1, and SBDS is identified downstream of FCN3.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Colin F. Davenport, Tobias Scheithauer, Alessia Dunst, Frauke Sophie Bahr, Marie Dorda, Lutz Wiehlmann, Doan Duy Hai Tran
Summary: Downregulation of multiple tumor suppressor genes is crucial in cancer formation, with epigenetic modifications playing a significant role. Using nanopore sequencing technology, the study identified potential TSGs in HCC and demonstrated the tumor suppressor function of GCK in inhibiting HCC cell proliferation through lactate accumulation-induced energy crisis. These findings offer valuable insights for further understanding tumorigenesis in human cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tze Hau Lam, Matthew Zirui Tay, Bei Wang, Ziwei Xiao, Ee Chee Ren
SCIENTIFIC REPORTS
(2015)
Article
Immunology
Bei Wang, Tze Hau Lam, Mun Kuen Soh, Zhiyong Ye, Jinmiao Chen, Ee Chee Ren
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Ziwei Xiao, Hui Ling Ko, Ee Hui Goh, Bei Wang, Ee Chee Ren
Article
Cell Biology
Bei Wang, Ziwei Xiao, Hui Ling Ko, Ee Chee Ren
Article
Biochemistry & Molecular Biology
B. Wang, D. Niu, T. H. Lam, Z. Xiao, E. C. Ren
CELL DEATH AND DIFFERENTIATION
(2014)
Article
Gastroenterology & Hepatology
Bei Wang, Ping Feng, Ziwei Xiao, Ee-Chee Ren
JOURNAL OF HEPATOLOGY
(2009)
Article
Multidisciplinary Sciences
Bei Wang, Dandan Niu, Liyun Lai, Ee Chee Ren
NATURE COMMUNICATIONS
(2013)
Article
Multidisciplinary Sciences
Chek Meng Poh, Guillaume Carissimo, Bei Wang, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Rhonda Sin-Ling Chee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Wen-Hsin Lee, Anthony Torres-Ruesta, Yee-Sin Leo, Mark I-Cheng Chen, Seow-Yen Tan, Louis Yi Ann Chai, Shirin Kalimuddin, Shirley Seah Gek Kheng, Siew-Yee Thien, Barnaby Edward Young, David C. Lye, Brendon John Hanson, Cheng- Wang, Laurent Renia, Lisa F. P. Ng
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Daniel Asarnow, Bei Wang, Wen-Hsin Lee, Yuanyu Hu, Ching-Wen Huang, Bryan Faust, Patricia Miang Lon Ng, Eve Zi Xian Ngoh, Markus Bohn, David Bulkley, Andres Pizzorno, Beatrice Ary, Hwee Ching Tan, Chia Yin Lee, Rabiatul Adawiyah Minhat, Olivier Terrier, Mun Kuen Soh, Frannie Jiuyi Teo, Yvonne Yee Chin Yeap, Shirley Gek Kheng Seah, Conrad En Zuo Chan, Emily Connelly, Nicholas J. Young, Sebastian Maurer-Stroh, Laurent Renia, Brendon John Hanson, Manuel Rosa-Calatrava, Aashish Manglik, Yifan Cheng, Charles S. Craik, Cheng- Wang
Summary: This study identified a series of antibodies that could block the fusion of viral and host membranes, but their neutralization efficacy against the live virus varied. These neutralizing antibodies not only blocked virus-induced cell fusion, but could also exacerbate cell damage. The findings suggest that stabilizing different Spike protein conformations could modulate virus-mediated membrane fusion, which has significant implications for COVID-19 pathology and immunity.
Article
Medicine, Research & Experimental
Yi-Hao Chan, Siew-Wai Fong, Chek-Meng Poh, Guillaume Carissimo, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Yun Shan Goh, Jackwee Lim, Weili Xu, Rhonda Sin-Ling Chee, Anthony Torres-Ruesta, Cheryl Yi-Pin Lee, Matthew Zirui Tay, Zi Wei Chang, Wen-Hsin Lee, Bei Wang, Seow-Yen Tan, Shirin Kalimuddin, Barnaby Edward Young, Yee-Sin Leo, Cheng- Wang, Bernett Lee, Olaf Rotzschke, David Chien Lye, Laurent Renia, Lisa F. P. Ng
Summary: This study comprehensively characterized the immune responses of asymptomatic COVID-19 patients, finding that they exhibit stronger protective mechanisms, lower levels of pro-inflammatory responses, and more effective immune responses compared to symptomatic patients. Additionally, asymptomatic patients had higher levels of growth factors associated with cellular repair in their bodies.
EMBO MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Matthew Zirui Tay, Angeline Rouers, Siew-Wai Fong, Yun Shan Goh, Yi-Hao Chan, Zi Wei Chang, Weili Xu, Chee Wah Tan, Wan Ni Chia, Anthony Torres-Ruesta, Siti Naqiah Amrun, Yuling Huang, Pei Xiang Hor, Chiew Yee Loh, Nicholas Kim-Wah Yeo, Bei Wang, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Jean-Marc Chavatte, Alicia Jieling Lim, Sebastian Maurer-Stroh, Lin-Fa Wang, Raymond Valentine Tzer Pin Lin, Cheng- Wang, Seow-Yen Tan, Barnaby Edward Young, Yee-Sin Leo, David C. Lye, Laurent Renia, Lisa F. P. Ng
Summary: The study found that the Delta variant of the SARS-CoV-2 virus can infect vaccinated individuals. Vaccine breakthrough cases showed lower memory B cell frequencies against the SARS-CoV-2 receptor-binding domain, but antibodies secreted by memory B cells retained neutralizing properties against the Delta variant. Inflammatory cytokines were lower in vaccine breakthrough infections compared to primary infections, highlighting the importance of vaccination in preventing inflammation.
EMBO MOLECULAR MEDICINE
(2022)
Article
Immunology
Bei Wang, Yun Shan Goh, Tessa Prince, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Pei Xiang Hor, Chiew Yee Loh, Siew Wai Fong, Catherine Hartley, Seow-Yen Tan, Barnaby Edward Young, Yee-Sin Leo, David C. Lye, Sebastian Maurer-Stroh, Lisa F. P. Ng, Julian A. Hiscox, Laurent Renia, Cheng- Wang
Summary: The rapid spread of SARS-CoV-2 variants B.1.1.7 from the UK and B.1.351 from South Africa has led to a second wave of COVID-19 cases globally. Antibody-mediated neutralization activity was reduced for B.1.1.7 and significantly attenuated for B.1.351, cautioning against solely relying on RBD mutations to evaluate vaccine efficacy. The study highlights the need for new SARS-CoV-2 vaccines not solely based on the ancestral Spike gene sequence.
Article
Medicine, Research & Experimental
Taichi Kuramochi, Siok Wan Gan, Adrian W. S. Ho, Bei Wang, Nagisa Kageji, Takeru Nambu, Sayaka Iida, Momoko Okuda-Miura, Wei Shan Chia, Chiew Ying Yeo, Dan Chen, Wen-Hsin Lee, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Cheng- Wang, Tomoyuki Igawa, Hideaki Shimada
Summary: This study demonstrates that through comprehensive engineering of the variable region, the engineered antibody, 5A6CCS1, is able to neutralize SARS-CoV-2 variants that escaped neutralization by the original antibody. In addition to improved affinity against variants, 5A6CCS1 was optimized for high solubility and low viscosity, enabling a high concentration formulation for subcutaneous injection. In animal experiments, 5A6CCS1 showed promising characteristics, highlighting the potential of antibody engineering to counteract escape variants.
Article
Health Care Sciences & Services
Bei Wang, Yun Shan Goh, Siew-Wai Fong, Barnaby Edward Young, Eve Zi Xian Ngoh, Jean-Marc Chavatte, Siti Nazihah Mohd Salleh, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Pei Xiang Hor, Chiew Yee Loh, Chia Yin Lee, Yi-Hao Chan, Zi Wei Chang, Matthew Zirui Tay, Angeline Rouers, Anthony Torres-Ruesta, Guillaume Carissimo, Mun Kuen Soh, Raphael Tze Chuen Lee, Yani Xu, Surinder Pada, Raymond Tzer Pin Lin, Yee-Sin Leo, David C. Lye, Sebastian Maurer-Stroh, Lisa F. P. Ng, Laurent Renia, Cheng- Wang
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Cell Biology
Yun Shan Goh, Jean-Marc Chavatte, Alicia Lim Jieling, Bernett Lee, Pei Xiang Hor, Siti Naqiah Amrun, Cheryl Yi-Pin Lee, Rhonda Sin-Ling Chee, Bei Wang, Chia Yin Lee, Eve Zhi Xian Ngoh, Cheng- Wang, Barnaby Edward Young, Paul A. Tambyah, Shirin Kalimuddin, Surinder Pada, Seow-Yen Tan, Louisa Jin Sun, Mark I-Cheng Chen, Yee-Sin Leo, David C. Lye, Lisa F. P. Ng, Raymond Tzer Pin Lin, Laurent Renia
Summary: Early detection of infection is crucial in limiting the spread of COVID-19, and a flow cytometry-based assay has been developed to detect SARS-CoV-2 spike protein antibodies in COVID-19 patients. The antibody response is significantly higher in later stages of infection, and the assay can also detect antibodies in asymptomatic individuals with high sensitivity, demonstrating its potential for serological analysis of both symptomatic and asymptomatic infections.
CELL REPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)