Article
Polymer Science
Hanlin Gang, Han Wang, Sitian Ma, Chaorong Wang, Lixing Bian, Zonglei Wang, Yingshan Zhou, Shaojin Gu, Xin Liu, Weilin Xu, Yan Zhuang, Hongjun Yang
Summary: In this study, hollow fibers with a skin-core structure were prepared using polylactic acid and silk fibroin as raw materials through wet spinning technology. Increasing the content of silk fibroin improved the uniformity and tensile properties of the hollow fibers, shortened the degradation time, and enabled precise controlled release of drugs.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Apollinariya A. Volokhova, Dmitry A. Fedorishin, Arina O. Khvastunova, Tatiana I. Spiridonova, Anna I. Kozelskaya, Julia Kzhyshkowska, Sergei I. Tverdokhlebov, Irina Kurzina
Summary: Surface modification with plasma can enhance biocompatibility and improve surface wettability and chemical bonding in polymeric electrospun scaffolds. It also increases drug release rates without compromising surface morphology and mechanical properties of the scaffolds. This technique can be useful for obtaining drug delivery systems with controlled release.
Article
Materials Science, Ceramics
Yue Hu, Degeng Xia, Huizhen Shen, Jinxuan Nan, Ning Ma, Zuoxing Guo, Xiaolong Wang, Quan Jin
Summary: Hydroxyapatite is commonly used as a bone substitute material, but its brittleness and low fatigue strength make it challenging to meet the long-term requirements of implants. This study developed a drug-loaded hydroxyapatite-polylactic acid composite through cold sintering process at 80 degrees Celsius, which achieved high densification, improved mechanical properties, and in-situ drug loading capability.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Coatings & Films
Zdenek Krtous, Jaroslav Kousal, Jana Sedlarikova, Zuzana Kolarova Raskova, Liliana Kucerova, Ivan Krakovsky, Jaromir Kucera, Suren Ali-Ogly, Pavel Pleskunov, Andrei Choukourov
Summary: Drug-loaded polymers with tunable composition and topology can be produced via plasma-assisted deposition of polyester thin films by thermal evaporation of polylactic acid. The released oligomers undergo hydrolysis to lactic acid over days, meeting biocompatibility demands. The films can expose micrometre-sized pores or buckling instabilities upon dissolution, enabling controlled release of antibacterial peptides for potential wound dressing and tissue-contacting devices.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Karla A. Barbosa, Isabella C. P. Rodrigues, Leticia Tamborlin, Augusto D. Luchessi, Eder S. N. Lopes, Lais P. Gabriel
Summary: Polymeric membranes are a promising alternative to conventional dressings for wound-healing applications. This study successfully produced and characterized poly(L-lactic acid) membranes incorporated with curcumin particles using rotary jet spinning technique. The membranes demonstrated thermal stability, adequate mechanical strength, low degradation rates, and sustained release of curcumin.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Polymer Science
Xiaosong Wang, Xu Zhang, Xiaozhao Han, Kun Liu, Chao Xu, Xianguo Hu, Zhenghui Jin
Summary: The study found that adding cellulose acetate can enhance the membrane's permeability, while porogens can increase the membrane's hydrophilicity, dialysis coefficient, and nutrient release rate. There was not a significant difference in membrane performance with different porogens, but urea coated with membranes containing nano-SiO(2) and PEG showed higher nutrient release rates.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Engineering, Environmental
Robiul Islam Rubel, Lin Wei
Summary: This study aims to develop a novel biochar-based controlled-release N fertilizer by formulating nitrogen fertilizer particles and applying a polylactic acid coating via the spray coating method. The results showed that the release time of 70% N from the BCRNFs particles into water could be controlled by adjusting the PLA coating content.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Engineering, Chemical
Mariangela Guastaferro, Lucia Baldino, Stefano Cardea, Ernesto Reverchon
Summary: Supercritical CO2-assisted electrospray was used to achieve sustained release of ceftriaxone sodium from polylactic acid nanoparticles. By adjusting the process conditions, the release time was increased by 240 times.
Article
Polymer Science
Lidia Verano Naranjo, Cristina Cejudo Bastante, Lourdes Casas Cardoso, Casimiro Mantell Serrano, Enrique Jose Martinez de la Ossa Fernandez
Summary: The study supported the use of supercritical solvent impregnation (SSI) as an efficient technique to develop ketoprofen-functionalized polylactic acid (PLA) for controlled drug release devices. By evaluating the influence of different SSI variables on polymer structure swelling and ketoprofen loading under various pressure/temperature conditions, the researchers found that higher pressure and temperature led to increased drug impregnation loads, with maximum impregnation at 200 bar and 75 degrees C. In vitro drug release tests showed that drug release profiles were dependent on specific pressure and temperature conditions used for impregnation of each polymer filament.
Article
Plant Sciences
Zhisheng Cen, Lin Wei, Kasiviswanathan Muthukumarappan, Abdus Sobhan, Rachel McDaniel
Summary: This study aims to develop a biochar-based controlled-release nitrogen fertilizer (BCRNF) to improve nitrogen supply time and rate, thereby increasing nitrogen use efficiency. Through impregnating ammonium sulfate in biochar and coating with polylactic acid, 70% of nitrogen was released in 12 days in water and 25 days in soil. The thermal stability was good, and the PLA concentration significantly affected the nitrogen release time and rate.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2021)
Article
Polymer Science
Leonid Galperin, Bat-hen Eylon, Boaz Mizrahi
Summary: The mechanical properties of polylactic acid can be modified through copolymerization and multi-armed structure. This study synthesized and characterized a series of liquid PEG(4)-PLA copolymers with different molecular weights of PDLLA or PLLA. It was found that the glass transition temperature and viscosity increased with increasing molecular weight and optical purity of the PLA segment. The release profiles of two model drugs were controlled by the molecular weight and dissolution of the polymeric carrier, suggesting the potential applications in biomedicine where viscosity plays a significant role.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Biotechnology & Applied Microbiology
Neerja Yadav, Lata Nain, Sunil Kumar Khare
Summary: Polylactic acid (PLA) is a key polymer due to its ecofriendly, biocompatible, and biodegradable properties, with potential to replace conventional polymers in various applications. Efforts to accelerate PLA degradation aim to enhance its commercial appeal, while the development of a bioprocess for high molecular weight PLA using enzymatic polymerization technique shows promise for future applications.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Polymer Science
Adam Vasicek, Petr Lenfeld, Lubos Behalek
Summary: This paper investigates the degradation of biocomposite materials with a PLA matrix containing ground natural waste fillers. The degradation of the material systems was evaluated through thermal and mechanical properties tests, as well as visual assessment using SEM images of the surfaces and fracture surfaces of the test specimens under controlled climatic aging.
Article
Chemistry, Physical
Noemi-Izabella Farkas, Laura Marincas, Reka Barabas, Liliana Bizo, Aranka Ilea, Graziella Liana Turdean, Monica Tosa, Oana Cadar, Lucian Barbu-Tudoran
Summary: Nanofibers were prepared using electrospinning in the system of PLA-HAP-Doxy for drug delivery purposes. The nanofibers with varying concentrations of Doxy demonstrated prolonged release capabilities, particularly when prepared by physical adsorption of 3 and 7 wt% Doxy-loaded PLA-HAP nanofibers.
Review
Biochemistry & Molecular Biology
T. Angelin Swetha, V. Ananthi, Abhispa Bora, Nallathambi Sengottuvelan, Kumar Ponnuchamy, Govarthanan Muthusamy, A. Arun
Summary: Due to its low carbon footprint and environmental friendliness, polylactic acid (PLA) is widely produced as a bioplastic. To increase its usage, it needs to be produced at the lowest cost possible, utilizing food wastes rich in carbohydrates as raw materials. Efficient manufacturing methods and necessary separation processes with low production costs are crucial for meeting the growing demand for PLA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Viviane Staendert, Kai Borcherding, Nicole Bormann, Gerhard Schmidmaier, Ingo Grunwald, Britt Wildemann
Summary: The study demonstrates the creation of a mechanically stable porous structure on a titanium surface and embedding of silver particles to enhance osteointegration and provide antibacterial properties through preoperative loading of antibiotics. The novel surface modification shows good biocompatibility, antibacterial effects, and support for osteointegration without negative impact of the released drug.
BIOACTIVE MATERIALS
(2021)
Review
Cell Biology
Franka Klatte-Schulz, Kathi Thiele, Markus Scheibel, Georg N. Duda, Britt Wildemann
Summary: The subacromial bursa, previously considered as friction-reducing tissue, is now recognized for its stem cell potential and ability to enhance the regeneration of adjacent tissues. This review explores the role of bursal inflammation as a pain generator and a potential initiator of healing. Therapeutic targets to overcome bursal inflammation and pain are discussed, and further research is needed to fully understand the interplay between the subacromial bursa and rotator cuff tendons.
Article
Biochemistry & Molecular Biology
Manuela Thierbach, Estelle Heyne, Michael Schwarzer, Lauren G. Koch, Steven L. Britton, Britt Wildemann
Summary: The risk of tendon disorders or ruptures increases with age, and intrinsic fitness also plays a role in affecting tendon properties. Low intrinsic fitness accelerates aging of tendons and leads to further impairment, resulting in decreased healing potential and elasticity.
Article
Biochemical Research Methods
Stefan Pentzold, Britt Wildemann
Summary: Mechanical overload decreases tenogenic differentiation and increases extracellular matrix remodeling/inflammation in stimulated fibroblasts, whereas physiological load may induce opposite effects.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Felix Christian Kohler, Philipp Schenk, Paul Koehler, Britt Wildemann, Gunther Olaf Hofmann, Steffen Derlien, Uta Biedermann, Isabel Graul, Jakob Hallbauer
Summary: The direction of PM screw fixation does not affect the primary stability of osteosynthesis of a posterior malleolus fracture. However, anterior to posterior screw fixation may result in slightly greater movement of the fracture. Anterior to posterior screw fixation could be a minimally invasive but stable surgical strategy for posterior malleolus fractures without significant dislocation.
APPLIED SCIENCES-BASEL
(2022)
Article
Microbiology
Marina Garcia-Moreno, Paul M. Jordan, Kerstin Guenther, Therese Dau, Christian Fritzsch, Monika Vermes, Astrid Schoppa, Anita Ignatius, Britt Wildemann, Oliver Werz, Bettina Loeffler, Lorena Tuchscherr
Summary: This study investigated the interaction between Staphylococcus aureus and osteoblasts or osteocytes during infection. The results showed that osteoblasts can induce an antimicrobial response and eliminate intracellular S. aureus, while osteocytes recruit immune cells and enhance inflammation but have a poor capacity for clearing bacterial infection. Additionally, signals from osteocytes enhance intracellular bacterial clearance by osteoblasts.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell & Tissue Engineering
G. G. Schulze-Tanzil, M. Delgado-Calcares, R. Stange, B. Wildemann, D. Docheva
Summary: Tendon healing is a major challenge due to its poor blood supply and slow metabolic rate. The disruption of cell-extracellular matrix interactions and uncontrolled inflammation can hinder successful healing. Optimizing Achilles tendon (AT) healing outcomes may involve adapting mechanical stimulation, restricting neoangiogenesis, and modifying stem cell niche parameters.
BONE & JOINT RESEARCH
(2022)
Article
Medicine, General & Internal
T. Fintan Moriarty, Willem-Jan Metsemakers, Mario Morgenstern, Marloes Hofstee, Alejandro Vallejo Diaz, James E. Cassat, Britt Wildemann, Melissa Depypere, Edward M. Schwarz, R. Geoff Richards
Summary: Fracture-related infection (FRI) is a common complication of bone fractures, where pathogenic bacteria enter the wound and hinder the healing process. This Primer provides an overview of the epidemiology, pathobiology, diagnosis, and management of these infections, as well as their impact on patient quality of life.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Medicine, General & Internal
Felix Christian Kohler, Philipp Schenk, Theresa Nies, Jakob Hallbauer, Gunther Olaf Hofmann, Uta Biedermann, Heike Kielstein, Britt Wildemann, Roland Ramm, Bernhard Wilhelm Ullrich
Summary: In the treatment of ankle fractures, complications related to wound healing after open reduction and internal fixation are a significant issue. A minimally invasive nail stabilization technique has been proposed as an alternative. This biomechanical study aimed to determine if this technique is comparable to the established method. The results showed that both the nail and plate fixations resulted in reduced stability and rotational stiffness compared to the intact ankle. While the nail fixation had greater rotational stiffness, both methods fell short of the native stability. The study suggests that weight-bearing after nail fixation should be evaluated on a case-by-case basis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shibarjun Mandal, Astrid Tannert, Christina Ebert, Rustam R. Guliev, Yvonne Ozegowski, Lina Carvalho, Britt Wildemann, Simone Eiserloh, Sina M. Coldewey, Bettina Loeffler, Luis Bastiao Silva, Verena Hoerr, Lorena Tuchscherr, Ute Neugebauer
Summary: Osteomyelitis, a difficult-to-treat bone infection caused by Staphylococcus aureus, was studied using mouse models. Fluorescence imaging and label-free Raman spectroscopy were used to characterize tissue changes and bacterial localization. The results showed that bacteria formed abscesses in the infected tissue, with lower numbers found in surrounding muscle tissue and trabecular bone tissue. Raman spectroscopic imaging revealed a metabolic state of the bacteria with reduced activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Manuela Thierbach, Michelle Mueller, Richard Stange, Daniel Kronenberg, Matthias Aurich, Britt Wildemann
Summary: Although prophylactic use of vancomycin is routinely performed after ACL reconstruction, it may potentially harm the tissue and cells. A comprehensive study was conducted to investigate its effect on tendon tissue and isolated tenocytes, and the results demonstrated that vancomycin at clinically used concentrations had no negative impact on cell viability, gene expression, histology, and mechanical integrity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Nicole Bormann, Aysha Schmock, Anja Hanke, Volker Eras, Norus Ahmed, Maya S. Kissner, Britt Wildemann, Jan C. Brune
Summary: Bone defects and infections present challenges for treatment, and this study evaluated the efficacy of different bone allografts in antibiotic absorption and release. The fibrous grafts showed the highest absorption capacity, while mineralized cancellous bone had the lowest absorption capacity. The fibrous grafts also exhibited prolonged antibiotic release and activity, making them suitable carrier grafts for antibiotic administration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Medicine, General & Internal
Jakob Hallbauer, Philipp Schenk, Lea Herrmann, Bernhard Wilhelm Ullrich, Uta Biedermann, Britt Wildemann, Gunther Olaf Hofmann, Felix Christian Kohler
Summary: The hook test is commonly used to assess syndesmosis stability during surgery, but there are no guidelines for the force required or the reliability of the test. In this study, ten experienced surgeons performed hook tests on cadaver bone models, with forces recorded in a blinded manner. Standardized hook tests were also performed on cadaver lower legs, revealing that the force and instability of the syndesmosis significantly influenced syndesmosis diastasis. However, even with maximum instability, only a small percentage of specimens showed significant diastasis (>2 mm). The hook test shows high variability and is not able to detect relevant syndesmosis injuries, even when performed in a standardized manner.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stefan Ferdinand Hertling, David Alexander Back, Britt Wildemann, Ekkehard Schleussner, Mario Kaiser, Isabel Graul
Summary: Mentoring programs have a positive impact on students' career planning, but the participation of surgical specialties is low. Increasing the availability of mentoring programs, with a special focus on women and more surgical content, can help address the shortage of surgical trainees.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Runa Kinitz, Estelle Heyne, Lauren G. Koch, Steven L. Britton, Manuela Thierbach, Britt Wildemann
Summary: Old age, adiposity, and metabolic disorders are risk factors for chronic tendinopathy, and aging seems to play a prominent role in molecular and structural alterations of Achilles tendon tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)