期刊
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
卷 34, 期 9, 页码 920-928出版社
SAGE PUBLICATIONS LTD
DOI: 10.5301/ijao.5000059
关键词
Bioglass; Gold nanoparticles; Sol-gel; Antibacterial activity
资金
- Project SAL-45 (Region of Lombardia, Italy)
- ALMAMATER Foundation (Pavia, Italy)
- International Center for Studies and Research In Biomedicine (ICB)
Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.
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