Article
Oncology
Caitlin Sok, Sameer Sandhu, Hardik Shah, Pranay S. Ajay, Maria C. Russell, Kenneth Cardona, Felipe Maegawa, Shishir K. Maithel, Juan Sarmiento, Subir Goyal, David A. Kooby, Mihir M. Shah
Summary: The study aimed to identify features on preoperative CT imaging that correlate with an increased risk of postoperative pancreatic fistula (POPF). The results showed that patients with a thick pancreatic neck and increased intra-abdominal girth have a heightened risk of CR-POPF after pancreatoduodenectomy, and they experience more serious postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sung Hyun Kim, Seung-seob Kim, Ho Kyoung Hwang, Chang Moo Kang, Jin-Young Choi, Kyung Sik Kim, Hyoung-Il Kim
Summary: This study aimed to verify the correlation between Hounsfield units (HU) and pancreatic texture and to propose a fistula risk score (FRS) that can be used preoperatively. Data from 545 patients undergoing pancreatoduodenectomy for malignant disease were retrospectively analyzed. HU levels were found to be associated with clinically relevant postoperative pancreatic fistula (POPF) and could predict pancreatic texture. The preoperatively chosen pancreatic texture based on HU levels showed comparable results with a previously reported FRS formula.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
E. W. Box, L. Deng, D. E. Morgan, R. Xie, J. K. Kirklin, T. N. Wang, M. J. Heslin, S. Reddy, S. Vickers, V Dudeia, J. B. Rose
Summary: Preoperative objective CT measurements can predict the development of postoperative pancreatic fistulae (POPF) and are comparable to established models relying on subjective intraoperative variables. Better preoperative stratification of high-risk patients can improve informed consent in this patient population.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Marius Lucian Savin, Florin Mihai, Liliana Gheorghe, Corina Lupascu Ursulescu, Dragos Negru, Ana Maria Trofin, Mihai Zabara, Vlad Nutu, Ramona Cadar, Mihaela Blaj, Oana Lovin, Felicia Crumpei, Cristian Lupascu
Summary: Preoperative CT scan-based morphologic parameters can accurately predict the risk of clinically relevant postoperative pancreatic fistula, and a risk score derived from multiple regression analysis presents a valuable tool for preoperative assessment of potential complications following surgery.
MEDICINA-LITHUANIA
(2021)
Article
Gastroenterology & Hepatology
Hiroki Imamura, Yoshito Tomimaru, Shogo Kobayashi, Hidenori Takahashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi
Summary: After pancreatojejunostomy for pancreatic head resection, contrast-enhanced computed tomography may reveal a hypoattenuated area at the pancreatojejunostomy site. The clinical significance of this hypoattenuated area in terms of postoperative pancreatic fistula is still unknown.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Hryhoriy Lapshyn, Natalie Petruch, Michael Thomaschewski, Stefan Sondermann, Katharina May, Laura Frohneberg, Ekaterina Petrova, Sergii Zemskov, Kim C. Honselmann, Rudiger Braun, Tobias Keck, Ulrich F. Wellner, Louisa Bolm
Summary: The study aimed to develop a preoperative POPF risk calculator using CT-based parameters to identify high-risk PD patients, and created a visual risk scale for quick assessment.
Article
Surgery
Maxwell T. Trudeau, Fabio Casciani, Brett L. Ecker, Laura Maggino, Thomas F. Seykora, Priya Puri, Matthew T. McMillan, Benjamin Miller, Wande B. Pratt, Horacio J. Asbun, Chad G. Ball, Claudio Bassi, Stephen W. Behrman, Adam C. Berger, Mark P. Bloomston, Mark P. Callery, Carlos Fernandez-del Castillo, John D. Christein, Mary E. Dillhoff, Euan J. Dickson, Elijah Dixon, William E. Fisher, Michael G. House, Steven J. Hughes, Tara S. Kent, Giuseppe Malleo, Ronald R. Salem, Christopher L. Wolfgang, Amer H. Zureikat, Charles M. Vollmer
Summary: This study aims to present different patient presentations of pancreatic fistula risk and define the effectiveness of mitigation strategies in the most prevalent and vulnerable scenarios for surgeons. Through analysis of data from multiple international institutions, specific scenarios and optimal mitigation approaches associated with CR-POPF occurrence were identified.
Article
Endocrinology & Metabolism
Margaux Homps, Philippe Soyer, Romain Coriat, Solene Dermine, Anna Pellat, David Fuks, Ugo Marchese, Benoit Terris, Lionel Groussin, Anthony Dohan, Maxime Barat
Summary: This study aimed to build a radiomics model using preoperative CT data to predict recurrence-free survival (RFS) or overall survival (OS) in patients with pNET. The results showed that patients with a radiomics index >0.4 had a shorter median RFS, but there was no significant association between the radiomics index and OS.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria-Chiara Ambrosetti, Alberto Ambrosetti, Giampaolo Perri, Clizia Gasparini, Giovanni Marchegiani, Roberto Salvia, Stefania Montemezzi, Giancarlo Mansueto, Giulia A. Zamboni
Summary: The objective of this study was to assess the correlation between pancreatic quantitative edge analysis and the incidence of postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy (PD). The results showed that patients with higher pancreatic stiffness and higher grade of POPF had higher scores in quantitative edge analysis. This suggests that quantitative edge analysis may help predict postoperative pancreatic fistula.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jenny H. Chang, Kathryn Stackhouse, Fadi Dahdaleh, Mir Shanaz Hossain, Robert Naples, Chase Wehrle, Toms Augustin, Robert Simon, Daniel Joyce, R. Matthew Walsh, Samer Naffouje
Summary: This study evaluated the predictive value of drain amylase on day 1 (DA-D1) after pancreaticoduodendectomy for the occurrence of postoperative pancreatic fistula (POPF). The results showed that DA-D1 < 720 U/L can be considered as a clinically useful predictor of clinically relevant POPF. Surgeons should consider removing the drain on the first postoperative day for patients with low risk.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Giovanni Capretti, Cristiana Bonifacio, Crescenzo De Palma, Martina Nebbia, Caterina Giannitto, Pierandrea Cancian, Maria Elena Laino, Luca Balzarini, Nickolas Papanikolaou, Victor Savevski, Alessandro Zerbi
Summary: A machine learning model was developed to predict the occurrence of CR-POPF after PD from preoperative CT scans, showing specificities, sensitivities, and predictive values. Interestingly, the model could also predict postoperative complications and length of stay based on the same data.
UPDATES IN SURGERY
(2022)
Article
Surgery
Giampaolo Perri, Giovanni Marchegiani, Stefano Partelli, Stefano Crippa, Beatrice Bianchi, Lorenzo Cinelli, Alessandro Esposito, Nicolo Pecorelli, Massimo Falconi, Claudio Bassi, Roberto Salvia
Summary: A preoperative predictive model for stratifying the risk of postoperative pancreatic fistula before pancreatoduodenectomy was developed and successfully validated in a separate cohort. Patients were categorized into low, intermediate, and high-risk groups based on body mass index and main pancreatic duct diameter, which accurately predicted the risk of postoperative pancreatic fistula.
Article
Gastroenterology & Hepatology
Nicolas Tabchouri, Morgane Bouquot, Helene Hermand, Olivier Benoit, Jean-Christophe Loiseau, Safi Dokmak, Beatrice Aussilhou, Sebastien Gaujoux, Olivier Turrini, Jean Robert Delpero, Alain Sauvanet
Summary: This study developed a predictive risk score for POPF following PD, which could more specifically identify low-risk patients compared to existing scores. Preoperative radiation therapy was identified as an independent protective factor.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Yunda Song, Subo Zhang
Summary: This study found that the level of urine creatinine on postoperative day 1 (POD1 CRE) is closely associated with the risk of CR-POPF. By combining POD1 CRE and POD1 DFA, patients can be classified into different risk groups, which can guide the removal of drainage tubes.
Article
Surgery
Elisa Bannone, Giovanni Marchegiani, Charles Vollmer, Giampaolo Perri, Giuseppa Procida, Gaetano Corvino, Sara Peressotti, Pier Giuseppe Vacca, Roberto Salvia, Claudio Bassi
Summary: This study aimed to evaluate the impact of postoperative serum hyperamylasemia (POH), with drain fluid amylase (DFA) and C-reactive protein (CRP), on the accuracy of the Fistula Risk Score (FRS) in assessing the risk of postoperative pancreatic fistula (POPF). The results showed that POH was an independent predictor of POPF and adding POH to the FRS improved the predictive accuracy.
Article
Obstetrics & Gynecology
Laura Lambicchi, Sara Ornaghi, Giulia Dal Molin, Giuseppe Paterlini, Davide P. Bernasconi, Francesca Moltrasio, Patrizia Vergani
Summary: Neonatal arterial ischemic stroke (NAIS) and hypoxic-ischemic neonatal encephalopathy (HINE) show distinct intrapartum and neonatal features, with perinatal asphyxia not appearing to be necessary for the occurrence of NAIS. There were no significant differences in placental histopathology among the groups.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Marta Barba, Davide P. Bernasconi, Stefano Manodoro, Matteo Frigerio
Summary: The risk of recurrent obstetric anal sphincter injuries in subsequent pregnancies is associated with maternal age, gestational age, occiput posterior presentation, oxytocin augmentation, operative delivery, and shoulder dystocia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Leonardo Centonze, Riccardo De Carlis, Ivan Vella, Luca Carbonaro, Niccolo Incarbone, Livia Palmieri, Cristiano Sgrazzutti, Alberto Ficarelli, Maria Grazia Valsecchi, Umberto Dello Iacono, Andrea Lauterio, Davide Bernasconi, Angelo Vanzulli, Luciano De Carlis
Summary: This study investigates the correlation between LI-RADS classification and pathological characteristics of HCC, as well as the prognostic implications on patient survival. The results suggest that LR-5 class is associated with unfavorable pathological features, while other factors such as patient age, performance status, and liver disease severity also play significant roles in postoperative outcomes.
Article
Nutrition & Dietetics
Marco Giani, Emanuele Rezoagli, Alice Grassi, Marco Porta, Luca Riva, Simone Famularo, Alessandro Barbaro, Davide Bernasconi, Davide Ippolito, Giacomo Bellani, Marco Braga, Giuseppe Foti, Luca Gianotti, Alessandro Giani
Summary: This study suggests that specific body composition indexes are associated with 90-day mortality in surgical patients admitted to the intensive care unit (ICU). Low skeletal muscle index (SMI) and myosteatosis are independently associated with increased 90-day mortality.
Article
Health Care Sciences & Services
Alessio Gerussi, Damiano Verda, Claudio Cappadona, Laura Cristoferi, Davide Paolo Bernasconi, Sandro Bottaro, Marco Carbone, Marco Muselli, Pietro Invernizzi, Rosanna Asselta
Summary: This study evaluated the feasibility and accuracy of using a machine learning model for disease risk prediction in Primary Biliary Cholangitis (PBC). The results showed that the model had high accuracy and specificity, and can be used for disease prediction in individuals at risk.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Guido Cavaletti, Alessia D'Acunti, Alessandro Porcu, Gabriella Masiello, Laura Del Campo, Gianfranca Traclo, Francesco De Lorenzo, Davide Paolo Bernasconi
Summary: Chemotherapy-induced neurotoxicity is a well-known complication of effective anticancer treatments, causing cognitive impairment and peripheral neuropathy. The social and economic effects of this condition on patients' lifestyles and relationships are under-investigated and largely unknown.
Review
Gastroenterology & Hepatology
Davide Ippolito, Cesare Maino, Marco Gatti, Paolo Marra, Riccardo Faletti, Francesco Cortese, Riccardo Inchingolo, Sandro Sironi
Summary: Hepatocellular carcinoma is a significant cause of global mortality and morbidity. The treatment of recurrent HCC lacks consensus, despite updates to treatment guidelines. Radiology plays a crucial role in the diagnosis and treatment of recurrent HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Oncology
Stefano Granieri, Alessia Kersik, Alessandro Bonomi, Simone Frassini, Davide Bernasconi, Sissi Paleino, Alessandro Germini, Elson Gjoni, Christian Cotsoglou
Summary: Lymph node metastases have a negative impact on the survival outcomes of patients with pancreatic cancer of the body and tail. This study systematically reviewed the literature to explore the incidence and prognostic impact of non-peripancreatic lymph nodes (PLNs) in these patients. The results showed an increased risk of death for patients with positive non-PLNs. Based on these findings, a systematic extended lymphadenectomy is not currently recommended for these patients.
Review
Medicine, General & Internal
Teresa Giandola, Cesare Maino, Giuseppe Marrapodi, Michele Ratti, Maria Ragusi, Vittorio Bigiogera, Cammillo Talei Franzesi, Rocco Corso, Davide Ippolito
Summary: Gastric cancer is a common cause of death worldwide. Accurate staging is crucial for optimal treatment, and endoscopy ultrasound (EUS) has been the reference standard for tumor and nodal statuses. However, computed tomography (CT) and magnetic resonance imaging (MRI) have gained importance in assessing distant metastases and primary gastric tumors. Positron emission tomography (PET) is also useful for nodal metastases and may play a future role in treatment. This review summarizes the advantages and pitfalls of these imaging techniques in TNM staging of gastric cancer patients.
Review
Medicine, General & Internal
Paolo Niccolo Franco, Chiara Maria Spasiano, Cesare Maino, Elena De Ponti, Maria Ragusi, Teresa Giandola, Simone Terrani, Marta Peroni, Rocco Corso, Davide Ippolito
Summary: The advancement of technology has led to the development of different CT scanners for dual-energy computed tomography (DECT). One recent detector-based technology allows for data collection from different energy levels, enabling efficient material decomposition. Through post-processing techniques, these scanners can generate various conventional and virtual images. A review of the clinical application of DECT, focusing on its usefulness in gastrointestinal imaging, is necessary due to the increasing number of published studies.
Review
Chemistry, Multidisciplinary
Paolo Niccolo Franco, Federica Vernuccio, Cesare Maino, Roberto Cannella, Milagros Otero-Garcia, Davide Ippolito
Summary: Radiomics is a new field of research that aims to improve diagnostic performance and support clinical decision-making by extracting mathematical features from medical images. Many studies have explored the potential applications of radiomics in gynecological imaging, including tumor diagnosis and staging, differentiation of histological subtypes, assessment of distant metastases, prediction of treatment response, recurrence, and patient outcome.
APPLIED SCIENCES-BASEL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Davide Ippolito, Cesare Maino, Ilaria Bianco, Silvia Girolama Drago, Raffaella Piazza, Nicolo Tamini, Luca Nespoli, Teresa Giandola, Sandro Sironi
Summary: This study aimed to assess the agreement and accuracy of radiologists in detecting specific features related to T- and N-stage in colon cancer staging. The results showed that radiologists' experience is one of the most important factors associated with the correct classification of colon cancer.
ABDOMINAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Massimo Cressoni, Andrea Cozzi, Simone Schiaffino, Paolo Cadringher, Paolo Vitali, Gianpaolo Basso, Davide Ippolito, Francesco Sardanelli
Summary: This study demonstrates a method to compute perfusion values of HCC, kidney, and pancreas using only two CT scan phases.
EUROPEAN RADIOLOGY EXPERIMENTAL
(2022)
Article
Gastroenterology & Hepatology
Marco Angrisani, Marco Ceresoli, Davide Ippolito, Fabio Pagni, Davide Gandola, Davide Seminati, Gabriele Casati, Sandro Sironi, Marco Braga, Linda Roccamatisi, Fabio Uggeri, Marta Sandini, Luca Gianotti
Summary: The study investigated the use of bioelectric impedance analysis to estimate fatty pancreas and its correlation with preoperative computed tomography scan and histologic evaluation. The results showed that bioelectric impedance analysis is a valid alternative method for assessing pancreatic steatosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Davide Ippolito, Carlo Capodaglio, Cesare Maino, Rocco Corso, Davide Leni, Davide Fior, Teresa Giandola, Maria Ragusi, Cammillo Talei Franzesi, Davide Gandola, Antonio Rovere, Sandro Sironi
Summary: The study retrospectively evaluated the use of compressive ultrasound in diagnosing DVT in SARS-CoV-2 infected patients. The incidence of DVT in the cohort was approximately 43%, with the left lower limb being the most commonly affected. DVT in the right and left popliteal vein distal tracts, along with D-dimer values, were independently associated with PE onset within 5 days.
JOURNAL OF ULTRASOUND
(2022)
