Article
Peripheral Vascular Disease
Wenting Guo, Wenbo Zhao, Dong Li, Haiying Jia, Changhong Ren, Sijie Li, Jing Zhao, Bingxin Yu, Jian Dong, Rongfen Guo, Kun Zhu, Yu Cao, Yan Wang, Ying Wang, Zunshan Li, Zhen Wang, Dan Wang, Chengbei Hou, Derek J. Hausenloy, Xi Chu, Xunming Ji
Summary: This study found that remote ischemic conditioning (RIC) has the potential to lower blood pressure in hypertensive patients. RIC was shown to reduce systolic blood pressure and is safe even in the absence of antihypertensive medications.
Article
Oncology
Yiu-fai Cheung, Vivian Wing-yi Li, Edwina Kam-fung So, Frankie Wai-tsoi Cheng, Jeffery Ping-wa Yau, Sau-ying Chiu, Wilfred Hing-sang Wong, Daniel Ka-leung Cheuk
Summary: This study investigated whether remote ischemic preconditioning (RIC) has cardioprotective effects on pediatric cancer patients receiving anthracycline-based chemotherapy. The results showed that RIC did not exhibit significant cardioprotective effects on myocardial injury.
JACC: CARDIOONCOLOGY
(2023)
Review
Surgery
Wenfu Zhang, Yingting Wu, Mingwang Zeng, Chao Yang, Zhengang Qiu, Rongrong Liu, Lifeng Wang, Maolin Zhong, Qiaoling Chen, Weidong Liang
Summary: In this systematic review and meta-analysis, the effect of remote ischemic conditioning (RIC) in reducing renal ischemia-reperfusion injury in patients undergoing kidney transplantation or partial nephrectomy was investigated. The results showed that the protective effect of RIC on renal ischemic-reperfusion was weak, and more studies are needed to confirm its nephroprotective effect.
FRONTIERS IN SURGERY
(2023)
Article
Critical Care Medicine
Martin Cour, Kada Klouche, Bertrand Souweine, Jean-Pierre Quenot, Carole Schwebel, Sophie Perinel, Camille Amaz, Marielle Buisson, Michel Ovize, Nathan Mewton, Laurent Argaud
Summary: The study did not find that remote ischemic conditioning (RECO) reduces the severity of organ failure in patients with septic shock, but the cumulative mortality within 90 days was slightly lower in the RECO group compared to the control group.
INTENSIVE CARE MEDICINE
(2022)
Article
Neurosciences
Xiuji Kan, Zeya Yan, Fei Wang, Xinyu Tao, Tao Xue, Zhouqing Chen, Zhong Wang, Gang Chen
Summary: Remote ischemic conditioning (RIC) is a remote, transient, and noninvasive procedure that provides temporary ischemia and reperfusion. This study conducted a comprehensive meta-analysis to evaluate the efficacy and safety of RIC for acute ischemic stroke. The results showed that RIC could reduce stroke recurrence, improve patients' prognosis, and did not cause other adverse events except for relatively benign RIC-related adverse events.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Alina Poalelungi, Delia Tulba, Elena Turiac, Diana Stoian, Bogdan Ovidiu Popescu
Summary: This study suggests that remote ischemic conditioning may improve disability and cognition in acute ischemic stroke patients, although there were no significant differences in clinical outcomes. The difference in infarct volume at 180 days was slightly larger in the sham group compared to the interventional group.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Kentaro Ishizuka, Takao Hoshino, Sono Toi, Takafumi Mizuno, Megumi Hosoya, Moeko Saito, Yasuto Sato, Yoshiki Yagita, Kenichi Todo, Manabu Sakaguchi, Takashi Ohashi, Kenji Maruyama, Shuji Hino, Yutaka Honma, Ryosuke Doijiri, Hiroshi Yamagami, Yasuyuki Iguchi, Teruyuki Hirano, Kazumi Kimura, Takanari Kitazono, Kazuo Kitagawa
Summary: The study aims to evaluate the efficacy of remote ischemic conditioning (RIC) on stroke patients, using the modified Rankin Scale (mRS) score as the evaluation criteria. The study is a randomized controlled trial with 400 patients divided into RIC group and control group. Patients are further divided into three groups based on the severity of stroke. The primary outcome is the functional recovery at 90 days after stroke onset, as assessed by the mRS score.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Yu Cui, Jing Zhang, Hui-Sheng Chen
Summary: This study aimed to evaluate the relationship between patient age and functional outcomes. The analysis of different age groups showed that the effect of remote ischemic conditioning (RIC) on functional recovery decreased with increasing age. This is the first report to demonstrate the age-related impact of RIC on functional outcomes in patients with acute moderate ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Oncology
Xian Wang, Xunming Ji
Summary: Sleep disturbances are common in stroke patients, and sleep quality plays a critical role in the onset and outcome of stroke. Research suggests that remote ischemic conditioning can improve post-stroke sleep quality, possibly through mechanisms related to sleep regulation.
FRONTIERS OF MEDICINE
(2021)
Article
Clinical Neurology
Wenbo Zhao, Fang Jiang, Sijie Li, Guiyou Liu, Chuanjie Wu, Yuang Wang, Changhong Ren, Jing Zhang, Fei Gu, Quanzhong Zhang, Xinjing Gao, Zongen Gao, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Daily remote ischemic conditioning for seven consecutive days was safe and tolerated in patients with intracerebral hemorrhage, potentially improving hematoma resolution rate and reducing relative perihematomal edema. However, further investigations are needed to evaluate the effects on absolute hematoma and perihematomal edema volume, as well as functional outcomes in this patient population.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Biochemistry & Molecular Biology
Siying Song, Linlin Guo, Di Wu, Jingfei Shi, Yunxia Duan, Xiaoduo He, Yunhuan Liu, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: The study showed that remote ischemic conditioning (RIC) induces significant changes in the plasma proteome of rhesus monkey models of strokes, involving proteins related to lipid metabolism, coagulation, immunoinflammatory responses, and endovascular hemostasis. These changes started as early as two weeks following the RIC intervention and continued for more than three weeks, indicating multiple protective effects induced by RIC.
Review
Clinical Neurology
Harry Keevil, Bethan E. Phillips, Timothy J. England
Summary: Remote ischemic conditioning (RIC) is a technique that aims to protect distant organs from ischemia by applying short periods of ischemia to another organ or tissue. It was initially developed for cardioprotection but has gained attention as a potential neuroprotective intervention. The mechanism behind RIC's neuroprotective effects is not fully understood, but preclinical studies suggest it could protect the brain from ischemia-reperfusion injury. Recent randomized control trials have shown promise in improving functional outcomes after acute ischemic stroke and preventing recurrent stroke. Further research is needed to explore the potential benefits of RIC in reducing vasospasm and improving cognitive outcomes in cerebrovascular diseases.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Immunology
Hillary J. Braun, Jennifer L. Dodge, Joshua D. Grab, Marisa E. Schwab, Iris H. Liu, Alexa C. Glencer, Peter G. Stock, Ryutaro Hirose, John P. Roberts, Nancy L. Ascher
Summary: The implementation of Share 35 policy led to an increase in LDLT volume, largely due to increased LDLT volume at centers with experience in LDLT, and corresponded to significant geographic variation in LDLT utilization.
Article
Clinical Neurology
Bowei Zhang, Wenbo Zhao, Hongrui Ma, Yunzhou Zhang, Ruiwen Che, Tingting Bian, Heli Yan, Jiali Xu, Lin Wang, Wantong Yu, Jia Liu, Haiqing Song, Jiangang Duan, Hong Chang, Qingfeng Ma, Qian Zhang, Xunming Ji
Summary: This study aimed to assess the safety and preliminary efficacy of remote ischemic conditioning (RIC) in preventing stroke-associated pneumonia (SAP) in patients with acute ischemic stroke. The results showed a lower incidence of SAP in the RIC group compared to the control group, although the difference was not significant. There were no significant differences in immunological profiles and blood parameters between the two groups, except for lower levels of IL-6 and IL-1 β in the RIC group.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Vivan Hellstroem, Gunnar Tufveson, Angelica Loskog, Mats Bengtsson, Gunilla Enblad, Tomas Lorant
Summary: Investigating the origin of urologic malignancies in renal transplant recipients can be beneficial in treating donor-derived cancers. This retrospective study found that a significant number of tumors in the urinary tract and kidney transplants were derived from the donor. In addition to conventional therapy, utilizing the immune response of the allograft against these tumors can be valuable.
Article
Surgery
Adam D. Barlow, Kourosh Saeb-Parsy, Christopher J. E. Watson
TRANSPLANT INTERNATIONAL
(2017)
Article
Immunology
Sarah A. Hosgood, Michael L. Nicholson
Article
Medicine, General & Internal
Sarah A. Hosgood, Kourosh Saeb-Parsy, Colin Wilson, Christopher Callaghan, Dave Collett, Michael L. Nicholson
Review
Endocrinology & Metabolism
Vishnu Swaroop Venkatanarasimhamoorthy, Adam D. Barlow
CURRENT DIABETES REPORTS
(2018)
Article
Surgery
Irum Amin, Charlotte Rutter, Adam Barlow, Neil K. Russell, J. Andrew Bradley, Andrew Jackson, Andrew J. Butler
JOURNAL OF INVESTIGATIVE SURGERY
(2019)
Article
Immunology
Shahid G. Farid, Magdy S. Attia, Dhakshina Vijayanand, Vivek Upasani, Adam D. Barlow, Sean Willis, Ernest Hidalgo, Niaz Ahmad
Meeting Abstract
Surgery
Duha Ilyas, Christopher Pearce, Richard Baker, Matthew Welberry-Smith, Adam Barlow, Sonsoles Martinez-Lopez, Jessica Weemes, Sunil Daga, David Keane
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Surgery
Duha Ilyas, Christopher Pearce, Richard Baker, Matthew Welberry-Smith, Adam Barlow, Sonsoles Martinez-Lopez, Jessica Weemes, Sunil Daga, David Keane
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Surgery
S. Farid, A. Magdy, D. Vijayanand, V. Upasani, S. Willis, A. Barlow, H. Ernest, A. Niaz
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Meeting Abstract
Surgery
M. Hamed, A. Barlow, S. Khosla, A. Sagar, F. Gribble, M. Murphy, G. Pettigrew, E. Bolton, J. Bradley, M. Nicholson, S. Hosgood, K. Saeb-Parsy
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Review
Transplantation
Ina Jochmans, Michael L. Nicholson, Sarah A. Hosgood
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2017)
Meeting Abstract
Surgery
M. Hamed, A. Logan, A. Dare, A. James, A. Barlow, J. Martin, N. Georgakopoulos, A. Gane, A. Gruszczyk, K. Crick, D. Fouto, C. Fear, E. Bolton, J. A. Bradley, G. Pettigrew, S. Hosgood, M. Nicholson, M. Murphy, K. Saeb-Parsy
BRITISH JOURNAL OF SURGERY
(2017)
Meeting Abstract
Surgery
O. M. Hamed, S. Hosgood, A. Logan, A. Dare, A. Barlow, J. Martin, N. Georgakopoulos, G. Pettigrew, E. Bolton, A. Bradley, M. Nicholson, M. Murphy, K. Saeb-Parsy
BRITISH JOURNAL OF SURGERY
(2016)
Meeting Abstract
Surgery
S. Hosgood, A. Barlow, M. Nicholson
BRITISH JOURNAL OF SURGERY
(2016)
Meeting Abstract
Surgery
Mazin Hamed, Angela Logan, Anna Dare, Andrew James, Adam Barlow, Jack Martin, Nikkitas Georgakopoulos, Alison Gane, Anja Gruszczyk, Keziah Crick, Diogo Fouto, Corrina Fear, Eleanor Bolton, Andrew Bradley, Gavin Pettigrew, Sarah Hosgood, Michael Nicholson, Mike Murphy, Kourosh Saeb-Parsy
TRANSPLANT INTERNATIONAL
(2017)