Article
Infectious Diseases
Daniel Christoph Richter, Maximilian Dietrich, Lazar Detelinov Lalev, Felix C. F. Schmitt, Mascha Onida Fiedler, Thomas Bruckner, Dominic Stoerzinger, Ute Chiriac, Sabrina Klein, Thilo Hackert, Thorsten Brenner, Alexander Brinkmann, Markus A. Weigand
Summary: Prolonged infusion of beta-lactams significantly reduces mortality in patients with septic shock, decreases the duration of invasive ventilation, and leads to a more pronounced reduction in SOFA scores within a 14-day period.
Article
Microbiology
Sonya Tang Girdwood, Min Dong, Peter Tang, Erin Stoneman, Rhonda Jones, Toni Yunger, Austin Ostermeier, Calise Curry, Melissa Forton, Traci Hail, Randi Mullaney, Patrick Lahni, Nieko Punt, Jennifer Kaplan, Alexander A. Vinks
Summary: This study developed population PK models of ceftriaxone in children admitted to a pediatric intensive care unit (PICU) and evaluated different dosing regimens. The study found that patient weight, age, creatinine clearance, and temperature significantly affected ceftriaxone clearance, while the presence of sepsis and phase of illness did not have a significant effect on PK parameters.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Chemistry, Medicinal
Luigi Principe, Tommaso Lupia, Lilia Andriani, Floriana Campanile, Davide Carcione, Silvia Corcione, Francesco Giuseppe De Rosa, Roberto Luzzati, Giacomo Stroffolini, Marina Steyde, Giuliana Decorti, Stefano Di Bella
Summary: Bacterial resistance mechanisms are continuously and rapidly evolving, especially for Gram-negative bacteria. The strategy of developing new beta-lactam/beta-lactamase inhibitors (BLs/BLIs) combinations has been successful, and data on several compounds are becoming available. Cefiderocol, with its unique mechanism of action, warrants separate discussion.
Article
Pharmacology & Pharmacy
Pengxiang Zhou, Yinchu Cheng, Guangna Cao, Yan Xing, Suodi Zhai, Xiaomei Tong, Kehu Yang
Summary: This study investigated the use of extended infusion (EI) or continuous infusion (CI) strategies in the management of neonatal sepsis in China. The results showed that only one-third of the respondents implemented these strategies, and there was a lack of understanding of the stability of the infusions. The study also found that more frequent multidisciplinary team discussions about antibiotic use and the appropriate work time in the neonatal ward were associated with an increase in the use of EI/CI strategy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Nicholas M. Smith, Alexa Ang, Fanny Tan, Katelyn Macias, Sarah James, Jasleen Sidhu, Justin R. Lenhard
Summary: Acinetobacter baumannii can reduce the bactericidal effect of an anti-staphylococcal beta-lactam, but high-intensity drug regimens are capable of sustained killing against Staphylococcus aureus, even in the presence of A. baumannii.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Nikki N. Tran, Ryan P. Mynatt, Keith S. Kaye, Jing J. Zhao, Jason M. Pogue
Summary: This retrospective cohort study found that extended infusion of beta-lactams is associated with improved clinical outcomes in patients with Gram-negative bacteremia, including shorter time to clinical stability, decreased treatment failure and recurrence, and shorter length of stay. These findings suggest that extended infusion is an important strategy for improving outcomes in patients with Gram-negative bacteremia.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Critical Care Medicine
Xiaoming Li, Yi Long, Guixin Wu, Rui Li, Mingming Zhou, Aiting He, Zhengying Jiang
Summary: This systematic review and meta-analysis found that prolonged intravenous infusion of beta-lactam antibiotics in patients with sepsis was associated with a significant reduction in all-cause mortality within 30 days, as well as lower hospital mortality, ICU mortality, and higher clinical cure. However, the certainty of the evidence was low and more studies are needed to confirm the results.
ANNALS OF INTENSIVE CARE
(2023)
Article
Infectious Diseases
Yang Mao, Nana Xu, Meichen Yan, Mingmin Pang, Xinyue Zhang, Haigang Wang, Juan Du, Dawei Wu, Hao Wang
Summary: This study aimed to explore the factors that drive physicians to choose prolonged infusion of β-lactam antibiotics in septic patients. The results showed that multidrug-resistant bacterial infection and septic shock were independent factors associated with prolonged infusion. However, the use of prolonged infusion had a survival benefit independent of disease severity, especially in less severe sepsis cases.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Chemistry, Applied
Nuno G. Alves, Americo J. S. Alves, Maria I. L. Soares, Teresa M. V. D. Pinho e Meloa
Summary: Spirocyclic molecules, especially the spiro-lactams subclass, are highly valued for their complex three-dimensional features and structural rigidity, making them extensively explored for their bioactivity and utility in various scientific fields such as drug design and organic synthesis. Efforts have been made towards developing new synthetic strategies for spirocyclic lactams due to their broad potential, with significant advancements reported since 2015 in the synthesis of spiro-beta-lactams and spiro-delta-lactams.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Pediatrics
Ronaldo Morales Junior, Gabriela Otofuji Pereira, Gustavo Magno Baldin Tiguman, Vanessa D'Amaro Juodinis, Joao Paulo Telles, Daniela Carla de Souza, Silvia Regina Cavani Jorge Santos
Summary: This study conducted a literature review to explore therapeutic targets and strategies for beta-lactam antibiotics in pediatric patients with sepsis. The findings suggest that individualized antimicrobial therapy and monitoring of beta-lactam serum concentrations can improve treatment outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Infectious Diseases
Sonia Luque, Adela Benitez-Cano, Leire Larranaga, Luisa Sorli, Maria Eugenia Navarrete, Nuria Campillo, Jesus Carazo, Isabel Ramos, Ramon Adalia, Santiago Grau
Summary: In critically ill patients treated with meropenem by extended or continuous infusion, there were no significant differences in drug exposure levels between patients with low body weight and normal body weight. The only factor independently associated with supratherapeutic drug exposure was a baseline estimated glomerular filtration rate (eGFR) < 90 mL/min.
Article
Pharmacology & Pharmacy
Yaru Peng, Iris K. Minichmayr, Han Liu, Feifan Xie, Lena E. Friberg
Summary: This study used pharmacometric multistate modeling to investigate predictors of in-hospital mortality in critically ill patients treated with meropenem. The study found that creatinine clearance and the duration of unbound concentrations exceeding the minimum inhibitory concentration significantly influenced the transitions and survival outcome of the patients.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
S. G. Passon, A. R. Schmidt, M. Wittmann, M. Velten, T. Baehner
Summary: Continuous infusion of ampicillin/sulbactam in critically ill patients showed therapeutic concentrations exceeding the minimum inhibitory concentration (MIC) breakpoint in all measurements and above the 4-fold MIC in the majority of analyses. However, patients with acute kidney injury had significantly higher serum concentrations, while impaired renal function and increased renal clearance affected drug levels.
Article
Critical Care Medicine
Renata Cerna Parizkova, Jirina Martinkova, Eduard Havel, Petr Safranek, Milan Kaska, David Astapenko, Jan Bezouska, Jaroslav Chladek, Vladimir Cerny
Summary: This study showed that fluid overload in infected patients can significantly affect the pharmacokinetic/pharmacodynamic parameters of meropenem, but these effects can be mitigated over time with appropriate monitoring and dosing adjustments.
Article
Infectious Diseases
Sanjay Singh, Tawanda Gumbo, Jan-Willem Alffenaar, Gunavanthi D. Boorgula, Prem Shankar, Tania A. Thomas, Keertan Dheda, Lesibana Malinga, Prithvi Raj, Santosh Aryal, Shashikant Srivastava
Summary: By testing and studying, it was found that the combination of meropenem with beta-lactamase inhibitors (BLIs) could potentially be an effective treatment regimen for multidrug-resistant tuberculosis (MDR-TB). The meropenem-vaborbactam-moxifloxacin backbone regimen has implications for creating a new effective MDR-TB regimen.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Pharmacology & Pharmacy
Eric Wenzler, Tristan T. Timbrook, Jordan R. Wong, John M. Hurst, Shawn H. MacVane
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2018)
Letter
Pharmacology & Pharmacy
Alyssa D. Rabon, Jon P. Fisher, Shawn H. MacVane
ANNALS OF PHARMACOTHERAPY
(2018)
Meeting Abstract
Critical Care Medicine
Alyssa Rabon, Jon Fisher, Joseph Mazur, Shawn MacVane
CRITICAL CARE MEDICINE
(2018)
Article
Infectious Diseases
Barbara A. Santevecchi, Tiffeny T. Smith, Shawn H. MacVane
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Immunology
Galen M. Kabulski, Shawn H. MacVane
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Microbiology
Mariana Castanheira, S. J. Ryan Arends, Andrew P. Davis, Leah N. Woosley, Amira A. Bhalodi, Shawn H. MacVane
Letter
Pharmacology & Pharmacy
Alyssa D. Rabon, Shawn H. MacVane
ANNALS OF PHARMACOTHERAPY
(2019)
Article
Infectious Diseases
Shawn H. MacVane, Brian R. Raux, Tiffeny T. Smith
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Letter
Microbiology
Romney M. Humphries, Kyle Spafford, Shawn MacVane
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Article
Infectious Diseases
Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland, S. Travis King, Kayla R. Stover, Kathey Rumley, Shawn H. MacVane, Jenna Swindler, Scott Kincaid, Trisha Branan, David Cluck, Benjamin Britt, Kelly E. Pillinger, Bruce M. Jones, Virginia Fleming, V. Paul DiMondi, Sandy Estrada, Brad Crane, Brian Odle, Majdi N. Al-Hasan, Julie Ann Justo
Article
Microbiology
Shawn H. MacVane, Niels Oppermann, Romney M. Humphries
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Hana R. Winders, Majdi N. Al-Hasan, Bruce M. Jones, Darrell T. Childress, Kayla R. Stover, Benjamin B. Britt, Elias B. Chahine, Suetping Lau, Pamela D. Andrews, Shauna Jacobson Junco, Rebekah H. Wrenn, Brad J. Crane, Jordan R. Wong, Megan M. Seddon, Christopher M. Bland, Shawn H. MacVane, Geneen M. Gibson, P. Brandon Bookstaver
Summary: The study aims to assess the utility of adjusting antibiotic use based on prevalence of bacterial isolates, finding that adjusting AU by microbiological burden leads to a more balanced comparison among hospitals.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Infectious Diseases
Shawn H. MacVane, Amira A. Bhalodi, Ryan K. Dare, Eric R. Rosenbaum, Kaleb Wolfe, Bradley Ford, Dilek Ince, Patrick Kinn, Kelly M. Percival, Romney M. Humphries
Summary: Implementation of AXDX testing for patients with Gram-positive bacteraemia shortened the time to optimal therapy (TTOT) and reduced unnecessary antibiotic exposure due to faster antibiotic modifications.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Amira A. Bhalodi, Shawn H. MacVane, Bradley Ford, Dilek Ince, Patrick M. Kinn, Kelly M. Percival, Derek N. Bremmer, Dustin R. Carr, Thomas L. Walsh, Micah M. Bhatti, Samuel A. Shelburne, Romney M. Humphries, Kaleb Wolfe, Eric R. Rosenbaum, Ryan K. Dare, Johann Kolev, Meghan Madhusudhan, Michael A. Ben-Aderet, Margie A. Morgan
Summary: The study demonstrates that using the Accelerate PhenoTest BC Kit (AXDX) for testing patients with bloodstream infections leads to significant reductions in time to optimal therapy, first antimicrobial modification, and time to antimicrobial deescalation.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Shawn H. MacVane, Ruchi Pandey, Lisa L. Steed, Barry N. Kreiswirth, Liang Chen
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)