期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 44, 期 3, 页码 263-268出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2014.05.014
关键词
Enterobacteriaceae; Plasmid-mediated quinolone resistance; Extended spectrum beta-lactamase genes; Plasmids
资金
- National Science Fund [31125026]
- Changjiang Scholars Programme of China
- National Natural Science Foundation
- Natural Science Foundation of Guangdong Province, China [U1201214]
In this study, 130 non-Typhi Salmonella enterica isolates from chickens were analysed for the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants as well as the co-existence of oqxAB and extended-spectrum beta-lactamase (ESBL) genes. The genes oqxAB, aac(6)-lb-cr, bla(CTX-M-9G) and bla(TEM) were present alone or in combination in 40(30.8%), 40(30.8%), 55(42.3%) and 2(1.5%) isolates, respectively. Most of the oqxAB-bla(CTX-M-9G)-positive isolates (17128) carried transferable ST2-IncHI2 plasmids containing an oqxAB cassette and bla(CTX-M-14) flanked by insertion sequences IS10 or ISEcp1 upstream and IS903 downstream. The oqxAB-bla(CTX-M-9G)-positive isolates from a local area showed similar pulsed-field gel electrophoresis (PFGE) patterns, whilst the isolates from different areas were genetically divergent, suggesting that both clonal expansion in local areas and horizontal transmission contributed to the spread of ST2-IncHI2 plasmids containing oqxAB and bla(CTX-M-14). This is the first report on the prevalence of ST2IncHI2 plasmids concomitantly carrying oqxAB and bla(CTX-M-14) in Salmonella and also the first description of the genetic environment of oqxAB-bla(CTX-M). The genetic linkage of oqxAB-bla(CTX-M-9G) in non-Typhi Salmonella likely facilitates the spread of antibiotic-resistant Salmonella and poses a threat for clinical treatment of salmonellosis. (C) 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据