Article
Infectious Diseases
Daniel Martak, Julia Guther, Tess D. Verschuuren, Benoit Valot, Nadine Conzelmann, Stefanie Bunk, M. Eugenia Riccio, Elena Salamanca, Alexandre Meunier, Charles P. Henriot, Caroline Pressacco Brossier, Xavier Bertrand, Ben S. Cooper, Stephan Harbarth, Evelina Tacconelli, Ad C. Fluit, Jesus Rodriguez-Bano, Jan A. J. W. Kluytmans, Silke Peter, Didier Hocquet
Summary: This study in five European cities found that food items were not the main source of ESBL-Ec and ESBL-Kp, as the strains from contaminated environments were genetically distinct from those in food. The findings suggest that human-to-human transmission is possibly the most frequent route of ESBL-Ec and ESBL-Kp transmission in high-income countries.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Microbiology
Shweta R. Singh, Alvin Kuo Jing Teo, Kiesha Prem, Rick Twee-Hee Ong, Elizabeth A. Ashley, H. Rogier van Doorn, Direk Limmathurotsakul, Paul Turner, Li Yang Hsu
Summary: Despite limited knowledge on the prevalence of ESBL-E and CPE in the Greater Mekong Subregion, recent trends show an increase in ESBL-producing E. coli in clinical and carriage specimens. Risk factors associated with ESBL-E isolation include recent antibiotic exposure, chronic kidney disease, and other co-morbidities. Collaboration on standardizing study methods is needed to improve monitoring and surveillance in the region, especially in community settings of Laos, Myanmar, Cambodia, and Yunnan and Guangxi provinces of China.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Zui Wang, Qin Lu, Xiaohui Mao, Li Li, Junfeng Dou, Qigai He, Huabin Shao, Qingping Luo
Summary: ESBL-producing E.coli strains isolated from chickens in central China showed high resistance to cephalosporins and harbored diverse ESBL-encoding genes. These strains pose a significant public health risk.
Article
Microbiology
Maya Frank Wolf, Raneen Abu Shqara, Karina Naskovica, Inna Amdur Zilberfarb, Inshirah Sgayer, Daniel Glikman, Hagai Rechnitzer, Vered Fleisher Sheffer, Jacob Bornstein
Summary: Maternal carriage and vertical transmission of ESBL-E pose a threat to preterm infants, leading to higher rates of complications. In this study, a correlation was found between placental inflammation and maternal ESBL-E colonization, highlighting the importance of surveillance and preventive measures.
Article
Medicine, General & Internal
Monica Romero Nieto, Sara Maestre Verdu, Vicente Gil, Carlos Perez Barba, Jose Antonio Quesada Rico, Reyes Pascual Perez
Summary: This study identified male sex, smoking, hypertension, urinary incontinence, and recurrent urinary tract infections as independent factors associated with the presence of ESBL-producing E. coli in patients with acute community-acquired pyelonephritis. The multivariate logistic models could correctly classify individuals with ESBL-producing E. coli infection in 80.2% of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Nina Langkabel, Janine Burgard, Sabrina Freter, Reinhard Fries, Diana Meemken, Luppo Ellerbroek
Summary: ESBL-producing E. coli is considered a major hazard in poultry, with poultry meat being a potential source of human infection. This study found ESBL-producing E. coli in broiler breast skin samples from different abattoirs, with the lowest incidence in the abattoir using conventional immersion scalding. Good kitchen hygiene is important to prevent infection by ESBL-producing E. coli and highly pathogenic phylogroups through chicken meat.
Article
Microbiology
Wen-Chi Chen, Chih-Hsin Hung, Yao-Shen Chen, Jin-Shiung Cheng, Susan Shin-Jung Lee, Fan-Chen Tseng, Ming-Fang Cheng, Jiun-Ling Wang
Summary: This study found a higher frequency of ST 131 strains and longer hospital stay in patients with cirrhosis in the ESBLEC group compared to the NESBLEC group in bloodstream infections. The 30-day re-admission/mortality rates were similar between the two groups, but ST 131 strains were associated with 30-day re-admission.
Article
Biochemistry & Molecular Biology
Harpreet Kaur, Vinay Modgil, Naveen Chaudhary, Balvinder Mohan, Neelam Taneja
Summary: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) and their extended-spectrum beta-lactamase (ESBL) production pose a significant threat to current antimicrobial treatment options. To overcome this challenge, the identification of new therapeutic targets is crucial. In this study, we used computational tools to identify potential drug targets against the ESBL-producing UPEC strain NA114, focusing on chokepoint, virulence, and resistance genes. Through a hierarchical in silico technique, we discovered seven distinct targets for this pathogen that showed no similarity to the human proteome. These targets, involved in bacterial peptidoglycan biosynthesis and inositol phosphate metabolism, hold promise for the design of effective drugs against MDR UPEC.
Article
Immunology
Esther Rios, Maria Del Carmen Lopez Diaz, Esther Culebras, Iciar Rodriguez-Avial, Carmen Rodriguez-Avial
Summary: In this study, the in vitro activity of fosfomycin against Escherichia coli isolated from urine samples in 2013, 2018, and 2021 was evaluated. The results showed an increasing trend of fosfomycin resistance in E. coli urinary isolates, which was associated with extended-spectrum beta-lactamases (ESBL) production.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2022)
Review
Public, Environmental & Occupational Health
H. Namikawa, W. Imoto, K. Yamada, Y. Tochino, Y. Kaneko, H. Kakeya, T. Shuto
Summary: This review evaluated 10 observational studies and found that previous antibiotic therapy, especially with cephalosporins and quinolones, as well as urinary catheter use, were predictive factors for ESBL-producing E. coli-induced bacteraemia.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Infectious Diseases
Jolinda de Korne-Elenbaas, Boas C. L. van der Putten, Niels D. M. Boek, Amy Matser, Constance Schultsz, Sylvia M. Bruisten, Alje P. van Dam
Summary: This study investigates the prevalence and transmission of ESBL-Ec strains among MSM in Amsterdam. It identifies unique ESBL-Ec strains involved in putative transmission between participants, suggesting a high probability of ESBL-Ec transmission in this population.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Agriculture, Dairy & Animal Science
Kwang-Won Seo
Summary: A simple and fast method for detecting ESBL- and pAmpC beta-lactamase-producing bacteria in samples with high bacterial load is important for clinical antimicrobial selection. The disk diffusion test, DDST, and multiplex PCR were used for phenotypic and genotypic detection of ESBL and pAmpC. The majority of isolates carried beta-lactamase genes, especially in samples grown on MacConkey agar containing cephalothin or ceftiofur.
Article
Infectious Diseases
Nguyen Thanh Viet, Vu Van Du, Nghiem Duc Thuan, Hoang Van Tong, Nguyen Linh Toan, Can Van Mao, Nguyen Van Tuan, Srinivas Reddy Pallerla, Dennis Nurjadi, Thirumalaisamy P. Velavan, Ho Anh Son
Summary: The study in Vietnam found that 30% of pregnant women had colonization of E. coli and Klebsiella species in their birth canals, with 47% of them producing ESBL. Carapenem resistance was low overall, but over 20% of Klebsiella species were resistant. This highlights the need for surveillance and molecular typing to combat the high rate of ESBL-producers and carbapenem resistance in Enterobacterales in Vietnam.
Article
Microbiology
Soomin Lee, Jae-Uk An, Jae-Ho Guk, Hyokeun Song, Saehah Yi, Woo-Hyun Kim, Seongbeom Cho
Summary: The study revealed a high prevalence of ESBL/AmpC-producing Escherichia coli in South Korean swine farms, with the highest infection rate observed in the weaning stage. CTX-M was detected in all stages, while CMY was predominantly found in the growing and finishing stages. Swine ESBL/AmpC-EC shared clone types with human counterparts, indicating a potential risk to humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Yushuang Wu, Shudi Huang, Donglai Zhang, Hua Ji, Yongqing Ni, Xueling Zhang, Juan Dong, Baokun Li
Summary: This study investigated drug resistance, molecular characteristics, and genetic relationship of ESBL-producing E. coli isolated from food and human stool samples in northern Xinjiang. A total of 127 E. coli strains were isolated, with 38 strains identified as ESBL-producing. These strains showed resistance to cefotaxime and cefepime, and sensitivity to meropenem. The most detected resistance gene was blaTEM, and the most detected virulence genes were fimH, ompA, hlyE, and crl. The isolates belonged to phylogroups B-1, C, and A. Among the plasmid replicon subtypes, IncFIB was the main type. The detected integrons were mostly of the first and third types. The 38 ESBL-producing E. coli strains had 19 different sequence types.
FOODBORNE PATHOGENS AND DISEASE
(2023)
Letter
Infectious Diseases
G. Catho, N. Peiffer-Smadja, J. Gras, L. Osei, M. Le Marechal
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Letter
Rheumatology
Valentin Lacombe, Martin Planchais, Charlotte Boud'Hors, Anne Croue, Clea Melenotte, Didier Raoult, Vincent Dubee, Yves-Marie Vandamme
Letter
Immunology
Anne-Gaelle Leroy, Stephane Corvec, Pierre Danneels, Vincent Dubee, Marie Kempf, Delphine Boucher, Nahema Issa, Olivia Peuchant, Fabrice Camou, David Boutoille, Raphael Lecomte
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
P. Le Turnier, M. Gregoire, G. Deslandes, K. Lakhal, C. Deschanvres, R. Lecomte, J-P Talarmin, V Dubee, R. Bellouard, D. Boutoille, A-G Leroy, B. J. Gaborit
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Letter
Infectious Diseases
Francois Benezit, Paul Le Turnier, Charles Declerck, Cecile Paille, Matthieu Revest, Vincent Dubee, Pierre Tattevin
LANCET INFECTIOUS DISEASES
(2020)
Article
Critical Care Medicine
Naike Bige, Jean-Remi Lavillegrand, Julien Dang, Philippe Attias, Stephanie Deryckere, Jeremie Joffre, Vincent Dubee, Gabriel Preda, Guillaume Dumas, Geoffroy Hariri, Claire Pichereau, Jean-Luc Baudel, Bertrand Guidet, Eric Maury, Pierre-Yves Boelle, Hafid Ait-Oufella
ANNALS OF INTENSIVE CARE
(2020)
Article
Multidisciplinary Sciences
Rachel Chenouard, Rafael Mahieu, David Luque Paz, Estelle Marion, Matthieu Eveillard, Vincent Dubee
Summary: This study compared the effects of ceftriaxone and temocillin on the abundance of ESBL-producing E. coli in the feces of colonized mice. The results showed that ceftriaxone increased the abundance of third-generation-cephalosporin resistant E. coli in feces, while temocillin had no effect or temporarily decreased the number of resistant E. coli. Using temocillin may help prevent the expansion of ESBL-PE in previously colonized patients.
Article
Medicine, General & Internal
Francois Morin, Delphine Douillet, Jean-Francois Hamel, Josue Rakotonjanahary, Florence Dupriez, Dominique Savary, Christophe Aube, Jeremie Riou, Vincent Dubee, Pierre-Marie Roy
Summary: This study aims to assess non-critical COVID-19 patients with L-POCUS within 48 hours of admission to determine the severity of lung damage and follow WHO recommendations for treatment.
Article
Infectious Diseases
Laura Escola-Verge, Pau Rello, Charles Declerck, Vincent Dubee, Frederic Rouleau, Xavier Duval, Gilbert Habib, Yoan Lavie-Badie, Guillaume Martin-Blondel, Lydie Porte, Kevin Bouiller, Francois Goehringer, Christine Selton-Suty, Cristiane da Cruz Lamas, Francisco Nacinovich, Nahema Issa, Clemence Richaud, Nadjib Hammoudi, Francisco Jose Barranco, Benito Almirante, Pierre Tattevin, Nuria Fernandez-Hidalgo
Summary: This study included 25 cases of infective endocarditis in pregnant women, showing that infective endocarditis in pregnant women is not uncommon. Strict medical surveillance involving a multidisciplinary team including obstetricians and neonatologists is required to manage these cases effectively.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Letter
Immunology
Pierre Danneels, Jean-Francois Hamel, Adrien Lemaignen, Vincent Cattoir, Vincent Dubee
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Charles Declerck, Rafael Mahieu, Diane Sanderink, Marine de la Chapelle, Pierre Abgueguen, Yves-Marie Vandamme, Vincent Dubee
Summary: This study reports on the acquisition and daily use of an ultrasonography device in a French infectious diseases ward. The results demonstrate the widespread use of POCUS and its positive impact on medical imaging requests. These findings highlight the significant potential of POCUS in infectious diseases specialties.
INFECTIOUS DISEASES NOW
(2022)
Letter
Infectious Diseases
Kevin Bouiller, Gaud Catho, Marion Le Marechal, Julien Gras, Maxime Hentzien, Nathan Peiffer-Smadja, Simon Bessis, Mathieu Cabon, Vincent Dubee, Adrien Lemaignen, Michael Thy, Capucine Martins, Pauline Thill, Lindsay Osei
INFECTIOUS DISEASES NOW
(2021)
Article
Pharmacology & Pharmacy
Rafael Mahieu, Vincent Dubee
ACTUALITES PHARMACEUTIQUES
(2020)
Article
Education & Educational Research
Nathan Peiffer-Smadja, Francois-Daniel Ardellier, Pauline Thill, Anne-Lise Beaumont, Gaud Catho, Lindsay Osei, Vincent Dubee, Alexandre Bleibtreu, Adrien Lemaignen, Michael Thy
BMC MEDICAL EDUCATION
(2020)
Article
Nutrition & Dietetics
Gaelle Annweiler, Mathieu Corvaisier, Jennifer Gautier, Vincent Dubee, Erick Legrand, Guillaume Sacco, Cedric Annweiler
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
