Article
Veterinary Sciences
Gui-Lin Wen, Shi-Hong Li, Zhe Qin, Ya-Jun Yang, Li-Xia Bai, Wen-Bo Ge, Xi-Wang Liu, Jian-Yong Li
Summary: This study isolated and characterized Clostridium difficile strains from clinical diseased dogs and cats, and found that the bacteria were quietly prevalent in pets with varying toxicities and genotypes. The isolates were highly susceptible to vancomycin and metronidazole but resistant to erythromycin and ciprofloxacin. The study highlights the importance of studying and paying attention to CDI in pets.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Lixue Liu, Hairong Wang, Wenping Xu, Yuelan Yin, Yanyan Ren, Huachao Bu, Dongdong Zhao
Summary: This study investigated the prevalence and infection source of Clostridium perfringens in egg hatcheries. The results showed that isolates from breeding duck farm had formed a dominant clone through long-term evolution, and some duck embryos were infected during the incubation period, with the possibility of vertical transmission.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Ren-feng Zhang, Yu-xia Man, Yuan-yuan Bai, Chun-hong Shao, Chun-mei Liu, Cong-hui Wang, Yong-xing Lei, Yong Wang, Yan Jin
Summary: This study identified and characterized five C. difficile 027 isolates in China, showing high resistance to fluoroquinolones. These isolates were confirmed through MLST, PCR ribotyping, and whole genome sequencing. The findings suggest that C. difficile 027 infections may be neglected in China, warranting further epidemiological studies nationwide.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Microbiology
Jia xin Zhong, Hao ran Zheng, Yuan yuan Wang, Lu lu Bai, Xiao li Du, Yuan Wu, Jin xing Lu
Summary: This study investigated the molecular types, antimicrobial resistance profiles, and resistance genes of Clostridium perfringens from human, animal, and food sources. The most prevalent molecular types of C. perfringens in humans were ST221, ST62, ST408, and ST493, while ST479 was the major type in animals. Analysis using cgMLST and cgSNP revealed genetic relatedness and transmission events. The study provides an overview of the epidemiological characteristics of C. perfringens with different origins and hosts in China.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Li Xiu, Chuangang Zhu, Zhaobing Zhong, Lixue Liu, Suo Chen, Wenping Xu, Hairong Wang
Summary: The study investigated the prevalence of Clostridium perfringens in different stages of a duck production chain in Weifang, China, revealing high contamination rates and antibiotic resistance. The close relationship between strains from humans and ducks highlights potential public health risks, suggesting the need for control measures not only at the slaughtering stage but also at the rearing stage.
Article
Public, Environmental & Occupational Health
S. K. Finsterwalder, I Loncaric, A. Cabal, M. P. Szostak, L. M. Barf, M. Marz, F. Allerberger, I. A. Burgener, A. Tichy, A. T. Fessler, S. Schwarz, S. Monecke, R. Ehricht, W. Ruppitsch, J. Spergser, F. Kuenzel
Summary: This study investigates whether dogs are carriers of resistant and/or virulent C. difficile strains. The results indicate that dogs may carry C. difficile strains that are both virulent and resistant to antibiotics.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Microbiology
Chao Wu, Changjie Lv, Ya Zhao, Weifeng Zhu, Liang Liu, Ting Wang, Chao Kang, Ying Yang, Xiaomei Sun, Qiang Zhang, Meilin Jin
Summary: This study conducted multilocus sequence typing on E. rhusiopathiae isolates in China, finding that ST48 was the main type associated with higher virulence. Some isolates exhibited resistance to antibiotics, with genome sequencing revealing suspected resistance genes and mutations.
Article
Food Science & Technology
Parvin Ghorbani Filabadi, Ebrahim Rahimi, Amir Shakerian, Zahra Esfandiari
Summary: This study identified the prevalence and genetic diversities of Clostridium difficile contamination in meat nuggets in Isfahan, Iran. Out of 600 food samples, 7 C. difficile strains were found, with a prevalence of 1.17%. The isolated strains were found to be toxigenic and resistant to antibiotics, except for vancomycin. The absence of the tcdC gene in the genome of all isolates may be due to a mutation.
JOURNAL OF FOOD QUALITY
(2022)
Article
Microbiology
Di Wang, Yamei Li, Chi Zhang, Yaling Zeng, Junping Peng, Feng Wang
Summary: The study conducted comprehensive molecular surveillance of antimicrobial-resistant Neisseria gonorrhoeae in Shenzhen from 2019 to 2020, providing important data for personalized treatment and adjustment of monitoring strategies. The resistance rate of ceftriaxone reached a stunning 24.87% in 2020. The increasing trend of ceftriaxone-resistant isolates with nonmosaic penA alleles highlights the need to monitor nonmosaic antimicrobial resistance mechanisms and develop molecular detection methods. Whole-genome sequencing analysis revealed the circulation of the internationally spreading FC428 clone with typical ceftriaxone resistance in the Shenzhen region. In summary, this comprehensive epidemiological study provides significant data for therapy management and improves surveillance strategies in China.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Di Wang, Yamei Li, Chi Zhang, Yaling Zeng, Junping Peng, Feng Wang
Summary: This study conducted a comprehensive molecular surveillance of 664 Neisseria gonorrhoeae isolates collected in Shenzhen, China. The results showed a high resistance rate of 24.87% to ceftriaxone in 2020, with a significant increase in nonmosaic penA alleles. The study also identified a notable ceftriaxone resistance rate in the ST11231 multilocus sequence typing, suggesting it may be a focus for future surveillance. The genomic analysis revealed the presence of internationally spreading FC428 clones with ceftriaxone resistance in the Shenzhen region. The study emphasizes the importance of continuous antimicrobial resistance surveillance for Neisseria gonorrhoeae.
MICROBIOLOGY SPECTRUM
(2023)
Article
Agriculture, Dairy & Animal Science
Jianfei Zhao, Rui Liu, Yanpeng Sun, Xiaojun Yang, Junhu Yao
Summary: This study revealed the potential safety hazards of commercial probiotic enterococci in China, particularly the presence of vancomycin-resistant Enterococcus (VRE). It also showed that there is a risk of horizontal transmission of VRE from feed to food.
Article
Cell Biology
Benshak J. Audu, Strachan Norval, Lopes Bruno, Ramjee Meenakshi, Macrae Marion, Ken J. Forbes
Summary: This study in Nigeria investigated the genomic diversity and antimicrobial resistance profile of Campylobacter in humans and livestock, finding a higher prevalence of resistance in Campylobacter isolated from livestock compared to humans. The results contribute to the understanding of the epidemiology of thermophilic Campylobacter in Nigeria.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Microbiology
Yizhun Li, Yamei Li, Leshan Xiu, Yaling Zeng, Chi Zhang, Liying Sun, LuLu Zhang, Feng Wang, Junping Peng
Summary: This study described the molecular epidemiology of antimicrobial resistance and the distribution of resistance-associated genotypes in Neisseria gonorrhoeae in Shenzhen, China from 2014 to 2018. Typing schemes revealed specific genotypes associated with decreased susceptibility to ceftriaxone, with certain sequence types showing international spread.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Khald Blau, Fabian K. Berger, Alexander Mellmann, Claudia Gallert
Summary: This study characterized virulence factors, antimicrobial resistance, ribotype distribution, and genetic relationship of C.difficile isolates from various fecally contaminated environmental sources. The results showed that the isolates had different virulence factors and antimicrobial resistance, indicating a potential for zoonotic transmission.
Article
Infectious Diseases
Teng Xu, Fenfen Zhou, Li Wang, Shi Wu, Haihui Huang
Summary: This study investigates the genomic and transcriptional changes associated with metronidazole resistance in Clostridioides difficile strains. The findings reveal an association between genomic variation and metronidazole resistance, and suggest that metronidazole resistance in C. difficile is influenced by factors such as metronidazole metabolism, cell wall thickness, and efflux pumps. These findings contribute to a better understanding of metronidazole resistance in C. difficile.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)