Article
Immunology
Jose Cedano, Michelle Baez, Fernando Pasteran, Sabrina Daiana Montana, Grace Ra, Venjaminne Fua, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, Maria Soledad Ramirez
Summary: This study tested the efficacy of the combination of sulbactam and a novel DBO, zidebactam, against carbapenem-resistant A. baumannii isolates. The results showed that the sulbactam/zidebactam combination was able to restore sulbactam susceptibility in resistant isolates, including those resistant to the sulbactam/avibactam combination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Patrice Nordmann, Mustafa Sadek, Camille Tinguely, Laurent Poirel
Summary: The rapid ResaImipenem/Acinetobacter NP test is highly specific and sensitive in detecting carbapenem resistance among Acinetobacter baumannii isolates. It is easy to implement, providing results within a short timeframe.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Review
Infectious Diseases
Carmi Bartal, Kenneth V. Rolston, Lior Nesher
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) predominantly causes colonization and infection in hospitalized patients. Distinguishing between the two is challenging. Treatment should be based on clear signs of infection and consideration of the presence of indwelling medical devices. Current treatment options are limited and combination therapy appears to be the best option.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Infectious Diseases
Samy Selim, Osama Ahmed Faried, Mohamed S. Almuhayawi, Osama A. Mohammed, Fayez M. Saleh, Mona Warrad
Summary: Acinetobacter baumannii is a nonfermenting Gram-negative bacterium associated with nosocomial infections. This study identified four distinct lineages of A. baumannii and found that genotype (A) isolates showed reduced effectiveness to certain antibiotics. Additionally, the binding affinity of imipenem towards Acinetobacter baumannii OXA beta-lactamase enzymes was investigated.
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Article
Infectious Diseases
Jia-Ling Yang, Chia-Jui Yang, Yu-Chung Chuang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study evaluated the susceptibility of carbapenem-resistant Acinetobacter baumannii (CRAB) clinical strains to minocycline, and found a significant correlation between tetB carriage and minocycline susceptibility in CRAB.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Multidisciplinary Sciences
Heng Kang Ng, Suat Moi Puah, Cindy Shuan Ju Teh, Nuryana Idris, Kek Heng Chua
Summary: This study aimed to detect the presence of gacA and gacS genes in carbapenem-resistant Acinetobacter baumannii (CRAB) isolates recovered from patients in intensive care units and investigate their pellicle forming ability. The results showed that all 96 clinical CRAB isolates carried the gacS and gacA genes, but only four isolates displayed the ability of pellicle formation.
Article
Multidisciplinary Sciences
Reem M. Hassan, Sherifa T. Salem, Saly Ismail Mostafa Hassan, Asmaa Sayed Hegab, Yasmine S. Elkholy
Summary: This study found that the most prevalent types of carbapenemase genes among CR-AB isolates collected from Egyptian patients were blaOXA-23, followed by blaNDM-1 and blaKPC.
Article
Biochemistry & Molecular Biology
Arnon Chukamnerd, Kamonnut Singkhamanan, Virasakdi Chongsuvivatwong, Prasit Palittapongarnpim, Yohei Doi, Rattanaruji Pomwised, Chanida Sakunrang, Kongpop Jeenkeawpiam, Mingkwan Yingkajorn, Sarunyou Chusri, Komwit Surachat
Summary: This study conducted whole-genome sequencing to understand the molecular epidemiology of carbapenem-resistant Acinetobacter baumannii (CRAB) in Southern Thailand. The most prevalent sequence type (ST) was ST2 and almost all isolates carried the bla(OXA-23) gene. Various antimicrobial resistance genes, mobile genetic elements, and virulence genes were identified. These findings provide crucial information for the control and treatment of CRAB infections.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Microbiology
Sara Alosaimy, Taylor Morrisette, Abdalhamid M. Lagnf, Leonor M. Rojas, Madeline A. King, Benjamin M. Pullinger, Athena L. Hobbs, Nicholson B. Perkins, Michael P. Veve, Jeannette Bouchard, Tristan Gore, Bruce Jones, James Truong, Justin Andrade, Glen Huang, Reese Cosimi, S. Lena Kang-Birken, Kyle C. Molina, Mark Biagi, Michael Pierce, Marco R. Scipione, Jing J. Zhao, Susan L. Davis, Michael J. Rybak
Summary: This study investigated the treatment of patients with Acinetobacter baumannii infections using Eravacycline (ERV), with the majority of isolates being carbapenem resistant. The results showed that patients treated with ERV combination therapy had a 30-day mortality rate of 23.9% and a low incidence of possible adverse events.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Pooja Kumari, Grace Kaul, T. Anand Kumar, Abdul Akhir, Manjulika Shukla, Suraj Sharma, Siddhesh S. Kamat, Sidharth Chopra, Harinath Chakrapani
Summary: Discovery of novel antibiotics targeting multidrug-resistant (MDR) pathogens such as A. baumannii is an urgent, unmet medical need. Our work has highlighted the potential of this unique scaffold to annihilate MDR A. baumannii alone and in combination with amikacin both in vitro and in animals, that too without inducing resistance. Further in depth analysis identified central metabolism to be a putative target. Taken together, these experiments lay down the foundation for effective management of infections caused due to highly MDR pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Amir Nutman, Gabrielle D. Levi, Alona Keren-Paz, David Schwartz, Samira Masarwa, Vered Schechner, Yehuda Carmeli
Summary: The carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat in healthcare settings and requires robust infection control measures. Our study found that the skin sponge method showed the highest sensitivity for detecting CRAB carriage, exceeding 90% in both acute care and post-acute care hospitals. Based on these findings, we recommend implementing the skin sponge method as the preferred approach for CRAB screening to optimize infection control strategies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Anke Breine, Megane Van Gysel, Mathias Elsocht, Clemence Whiteway, Chantal Philippe, Theo Quinet, Adam Valcek, Johan Wouters, Steven Ballet, Charles Van der Henst
Summary: This article investigates the issue of carbapenem-resistant Acinetobacter baumannii bacteria and identifies a compound with inhibitory activity against these strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Kai Lucassen, Carina Mueller, Julia Wille, Kyriaki Xanthopoulou, Meredith Hackel, Harald Seifert, Paul G. Higgins
Summary: The most prevalent tigecycline resistance mechanisms in carbapenem-resistant Acinetobacter baumannii isolates were caused by alterations in the regulators of RND-type efflux pumps, with disruption of the adeN gene being the most common. Mutations and IS element disruptions in the adeRS regulatory system from Southern European countries were associated with higher tigecycline MICs, although less commonly observed.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Abera Abdeta, Adane Bitew, Surafel Fentaw, Estifanos Tsige, Dawit Assefa, Tadesse Lejisa, Yordanos Kefyalew, Eyasu Tigabu, Martin Evans
Summary: The study detected a high prevalence of multidrug-resistant and extremely drug-resistant carbapenemase-producing gram-negative bacteria, particularly among intensive care unit patients at healthcare facilities. This highlights the increasing difficulty in clinical management of infected patients and the need for last-resort antibiotics, potentially worsening the global antimicrobial resistance crisis. Robust antimicrobial resistance monitoring and infection prevention and control programs are necessary.
Letter
Infectious Diseases
Jia-Arng Lee, Shin-Hei Du, Tai-fen Lee, Yu-Shan Huang, Chun-Hsing Liao, Yu-Tsung Huang, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Yuag-Meng Liu, Wen-Chien Ko, Mao-Wang Ho, Yu-Lin Lee, Po-Ren Hsueh
JOURNAL OF INFECTION
(2023)
Letter
Infectious Diseases
Jiaxin Yu, Hsiu-Hsien Lin, Kun-Hao Tseng, Ni Tien, Po-Ren Hsueh, Der-Yang Cho
JOURNAL OF INFECTION
(2023)
Article
Immunology
Hon-Yen Wu, Yi-Tsung Lin, Wan-Chuan Tsai, Yen-Ling Chiu, Mei-Ju Ko, Ju-Yeh Yang, Mei-Fen Pai, Hsin-Sui Hsu, Shih-Ping Hsu, Yu-Sen Peng, Chun-Hsing Liao
Summary: This study aimed to investigate the distribution of Enterobacteriaceae in the gut microbiota of hemodialysis patients and analyze its association with clinical parameters. The study found significant differences in the gut microbiota composition at the genus level between hemodialysis patients and the control group, with an increase in the Escherichia-Shigella complex and an association between Klebsiella and emergency room visits. Therefore, further research on the microbiota composition of Enterobacteriaceae is necessary.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Environmental Sciences
Shin-Huei Kuo, Tzu-Yin Liu, Tun-Chieh Chen, Chih-Jen Yang, Yen-Hsu Chen
Summary: The study found that PVDC plastic wraps are the best choice for covering elevator buttons, with very low residual bacteria. Door-close and -open buttons were the most frequently touched sites, requiring more accurate and precise disinfection, therefore cleaning intervals of no longer than three hours may be warranted.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Immunology
Shu-Hsing Cheng, Chia En Lien, Szu-Min Hsieh, Chien-Yu Cheng, Wang-Da Liu, Ching-Lung Lo, Wen-Chien Ko, Yen-Hsu Chen, Ching-Tai Huang, Hsiao-Ting Chang, Shinn-Jang Hwang, Ning-Chi Wang, Ming-Che Liu, Yu-Lin Lee, I-Chen Tai, Josue Antonio Garcia Estrada, Tzou-Yien Lin, Wen-Sen Lee
Summary: This study assessed the safety and immunogenicity of the MVC-COV1901 vaccine in people living with HIV. The vaccine showed robust safety but weaker immune responses in this population, suggesting the need for further investigations to determine improved immunization strategies for HIV patients.
Article
Infectious Diseases
Chun-Hsing Liao, Ren-Hsuan Ku, Li-Hua Li, Cheng-Mu Wu, Tsuey-Ching Yang
Summary: In our recent study, we found that the yceA-cybB-yceB gene cluster is up-regulated in the presence of oxidative stress. This gene cluster plays a role in alleviating oxidative stress, enhancing swimming motility, and increasing susceptibility to certain antibiotics.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Letter
Immunology
Chin-Shiang Tsai, Jiun-Ling Wang, Nan-Yao Lee, Po-Lin Chen, Ying-Jun Lin, Huey-Pin Tsai, Shu-Li Su, Hsin-Hui Huang, Lin-Wen Mao, Han Siong Toh, Wen-Chien Ko
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Review
Infectious Diseases
Chao-Ying Chen, Yu-Yao Chiu, Yu-Cheng Chen, Chung-Hao Huang, Wen-Hung Wang, Yen-Hsu Chen, Chun-Yu Lin
Summary: This study conducted a systematic review and meta-analysis to investigate the association between obesity and the severity of dengue. The results indicated that obese patients, especially pediatric patients, are more likely to develop severe dengue.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Ching-Chi Lee, Yuan-Pin Hung, Chih-Chia Hsieh, Ching-Yu Ho, Chiao-Ya Hsu, Cheng-Te Li, Wen-Chien Ko
Summary: This study aimed to develop scoring systems to predict short-term mortality and length of hospital stay in patients with bacteraemia. The study found that clinical variables that dynamically changed from day 0 to day 3 were crucial in predicting the outcomes.
BMC INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Ming-Ta Chuang, Mei-Tsz Su, Chen-Hsi Chou, Yu-Ling Liang, Hsing-Fen Tsai, Pei-Hsiu Yu, Meng-Hsing Wu, Wen-Chien Ko, Pei-Yin Tsai
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Imaniar Noor Faridah, Haafizah Dania, Rita Maliza, Wan-Hsuan Chou, Wen-Hung Wang, Yen-Hsu Chen, Dyah Aryani Perwitasari, Wei-Chiao Chang
Summary: Dengue is a global arboviral disease that has become a major public health concern. This study investigated the associations of variations in the MICB and PLCE1 genes with dengue severity and thrombocytopenia in Indonesian and Taiwanese populations. The results showed associations between MICB rs3132468 and dengue shock syndrome (DSS), as well as between PLCE1 rs3740360 and secondary dengue hemorrhagic fever (DHF) in Indonesian patients.
Article
Infectious Diseases
Bing-Jie Shen, Jann-Tay Wang, Hou-Tai Chang, Shan-Chwen Chang, Chun-Hsing Liao
Summary: Active surveillance for sputum cultures revealed Burkholderia cepacia infection in an intensive care unit from September 2008 to September 2009. The use of disposable ventilator circuits resulted in a decrease in infection rates, and this effect persisted in the following years.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Zih-Syuan Yang, Wen-Hung Wang, Yu-Ting Lin, Chih-Yen Lin, Aspiro Nayim Urbina, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: This study investigates the individual and collaborative roles of DC-SIGN and Gal3 in H5N1 and H7N9 avian influenza virus (AIV) infection. It is found that DC-SIGN expression significantly promotes viral infection, while Gal3 knockdown reduces viral infection. The co-expression of DC-SIGN and Gal3 enhances infectivity of H5N1 and H7N9 viruses, with stronger regulatory capabilities for H5N1. The study reveals the significance of DC-SIGN and Gal3 in regulating AIV infection and suggests the potential of targeting their interaction with HA protein as antiviral strategies.
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)