期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 39, 期 5, 页码 431-434出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2011.12.009
关键词
Plasmid-mediated quinolone resistance (PMQR); Extended-spectrum beta-lactamases (ESBLs); qnr
资金
- Consejeria de Innovacion Ciencia y Empresa, Junta de Andalucia [P07-CTS-02908, CTS-5259, PI-0282-2010]
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III
- European Regional Development Fund 'A way to achieve Europe' ERDF
- Spanish Network for the Research in Infectious Diseases [REIPI RD06/0008]
- Instituto de Salud Carlos III (PFIS), Spain
The presence of the plasmid-mediated quinolone resistance determinants qnrA, qnrB, qnrS and aac(6')-Ib-cr was evaluated in a collection of 382 isolates of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae collected between February and March 2006 for the nationwide Spanish GEIH-ESBL 2006 project. In total, 14 isolates (3.7%) were positive for qnr genes (3 qnrA1, 5 qnrB-like and 6 qnrS1) and 62 isolates (16.2%) were positive for the mutant variant of aac(6')-Ib-cr. The Aac(6')-Ib-cr enzyme was the most prevalent plasmid-mediated mechanism of quinolone resistance in Spain. Most of the Aac(6')-Ib-cr-producing E. coli isolates (94.2%) carried two mutations in gyrA and two in parC, whilst only 57.2% of K. pneumoniae harbouring this enzyme were gyrA and/or parC mutants. Most qnr plasmids were transferable, but only four were conjugative. Plasmid incompatibility groups were identified for only four plasmids, belonging to FIA, HI2 and I1 gamma. The most prevalent ESBLs associated with qnr plasmids belonged to the SHV and CTX-M families. The present study highlights the broad geographical spread of qnr-like determinants in Spain and their association with the SHV-12 and CTX-M-9 ESBLs in human clinical isolates. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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