Article
Infectious Diseases
Tatjana Khromov, Gry Helene Dihazi, Phillipp Brockmeyer, Andreas Fischer, Frank Streit
Summary: The study evaluated the CLAM-2000 automated preanalytical sample preparation module with LC-MS/MS as a method for 24/7 TDM of beta-lactam antibiotics in routine clinical diagnostics. The method showed good linearity, accuracy, and precision, with stable internal standards stored in the instrument.
Article
Microbiology
Ashlan J. Kunz Coyne, Mohammad Alshaer, Anthony M. Casapao, Veena Venugopalan, Carmen Isache, Jason Ferreira, Christopher A. Jankowski
Summary: This study compared clinical outcomes in hospitalized patients with Pseudomonas aeruginosa pneumonia or bloodstream infection who received beta-lactam antibiotic infusions with and without the guidance of therapeutic drug monitoring. The results showed that therapeutic drug monitoring decreased the odds of treatment failure, but also increased the risk of infection-related readmissions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xi Yang, Chen Mei, Xiaoying He, Lingjuan He, Xiaoyang Lu, Hongyan Tong, Yan Lou
Summary: A rapid, sensitive, and reliable UPLC-MS/MS method for quantification of venetoclax in plasma was developed and validated. The method showed potential application in the treatment of acute myeloid leukemia and the plasma concentration of venetoclax was found to be correlated with AST levels and age.
Article
Biochemistry & Molecular Biology
Ying Li, Lu Meng, Yinling Ma, Yajing Li, Xiaoqing Xing, Caihui Guo, Zhanjun Dong
Summary: This study developed a simple and effective UPLC-MS/MS method for simultaneous quantification of osimertinib, aumolertinib, and furmonertinib in human plasma, which can be used for TDM. The method is sensitive, reliable, and easy to use, potentially reducing the incidence of adverse effects.
Article
Chemistry, Analytical
Zhenjie Ye, Lingjie Wu, Xiaoying Zhang, Yingying Hu, Ling Zheng
Summary: A method for simultaneous quantification of multi-targeted tyrosine kinase inhibitors sorafenib, lenvatinib, and apatinib in human plasma was developed in this study for therapeutic drug monitoring in hepatocellular carcinoma patients. The method showed satisfactory specificity, precision, accuracy, matrix effects, extraction recovery, and stability, providing a sensitive, rapid, and simple approach for drug analysis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Infectious Diseases
Jan Stasek, Filip Keller, Veronika Koci, Jozef Klucka, Eva Klabusayova, Ondrej Wiewiorka, Zuzana Strasilova, Miroslava Benovska, Marketa Skardova, Jan Malaska
Summary: Beta-lactam antibiotics are widely used in critical care due to their safety and efficacy. Achieving adequate plasma concentrations of antibiotics is crucial for effective treatment, but this can be challenging in critically ill patients due to physiological changes. Therapeutic drug monitoring (TDM) has proven to be effective in ensuring appropriate antibiotic concentrations, but there are limitations, such as long turnaround times. Further research is needed to determine if TDM can improve patient outcomes.
Article
Pharmacology & Pharmacy
Wei Lu, Meng Pan, Hongqin Ke, Jun Liang, Wenbin Liang, Ping Yu, Penghua Zhang, Qibin Wang
Summary: Antimicrobial resistance (AMR) is a global health threat due to the widespread use of antibacterial drugs. Pharmacokinetic/pharmacodynamic (PK/PD) studies of antibiotics are a preventive approach to delay AMR. We developed a method to determine 18 antibacterial drugs in human plasma for clinical therapeutic drug monitoring (TDM).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Alexandre Guironnet, Laure Wiest, Emmanuelle Vulliet
Summary: The use of beta-lactams in veterinary and human medicine has increased in the past decade, representing a significant portion of overall consumption. This study developed a modified QuEChERS method for extraction and analysis of beta-lactams from sewage treatment plant sludge, showing satisfactory performance for quantification and detection. Through optimization and validation, the method proved effective in extracting beta-lactams from solid environmental matrices.
Article
Infectious Diseases
G. Macheda, N. El Helali, G. Pean de Ponfilly, M. Kloeckner, P. Garcon, M. Maillet, V Tolsma, C. Mory, A. Le Monnier, B. Pilmis
Summary: This study retrospectively analyzed therapeutic drug monitoring (TDM) data of patients with infective endocarditis (IE) and found that current guidelines may lead to unnecessarily high drug concentrations in most patients. TDM benefits predominate in patients with altered renal function, but probably limit adverse effects related to overdosing in most patients.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Review
Medical Laboratory Technology
Alan Abdulla, Puck van den Broek, Tim M. J. Ewoldt, Anouk E. Muller, Henrik Endeman, Birgit C. P. Koch
Summary: This study provides an overview of the current practices of beta-lactam therapeutic drug monitoring (TDM) and identifies barriers and facilitators in its clinical implementation. The main barriers include insufficient knowledge and unavailability of assays, while doubts about cost-effectiveness and clinical effectiveness hinder its broad implementation. Collaboration between physicians and clinical pharmacists and microbiologists can improve physicians' willingness to use beta-lactam TDM.
THERAPEUTIC DRUG MONITORING
(2022)
Review
Chemistry, Inorganic & Nuclear
Micha Zabiszak, Justyna Frymark, Kazuma Ogawa, Monika Skrobanska, Martyna Nowak, Renata Jastrzab, Malgorzata T. Kaczmarek
Summary: Beta-lactam antibiotics are widely used in medicine due to their strong antibacterial activity. They are produced by fungi and bacteria, and their advantages lie in their potent bactericidal activity and wide spectrum of activity. The common mode of action of beta-lactam antibiotics involves inhibiting the synthesis of the bacterial cell wall, leading to the demise of the bacterial cell.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Applied
Jing Wu, ErLing Guo, MengLin Wang, Ke Wang, Ling Ma, Kaoqi Lian
Summary: This study developed an effective method for the simultaneous determination of 52 types of β-lactam antibiotics (ss-LAs) in meat and poultry, aquatic products, milk, and eggs samples. The method involves a modified QuEChERS sample preparation technique combined with UPLC-MS/MS. The results demonstrate excellent linearity, low detection limits, and good recovery rates, making it a powerful tool for monitoring ss-LAs residues in animal derived foods.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Infectious Diseases
Tim M. J. Ewoldt, Alan Abdulla, Puck van den Broek, Nicole Hunfeld, Soma Bahmany, Anouk E. Muller, Diederik Gommers, Suzanne Polinder, Henrik Endeman, Inge Spronk, Birgit C. P. Koch
Summary: This study aimed to identify healthcare professionals' barriers and facilitators for implementing therapeutic drug monitoring (TDM) of beta-lactams and ciprofloxacin in Dutch intensive care units (ICU). The findings revealed that a lack of conclusive evidence, organizational support, and low availability of assays were the major barriers. Education, clear guidelines, and organizational support were identified as important factors for successful implementation strategies.
BMC INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
H. Ceren Ates, Hasti Mohsenin, Christin Wenzel, Regina T. Glatz, Hanna J. Wagner, Richard Bruch, Nico Hoefflin, Sashko Spassov, Lea Streicher, Sara Lozano-Zahonero, Bernd Flamm, Rainer Trittler, Martin J. Hug, Maja Koehn, Johannes Schmidt, Stefan Schumann, Gerald A. Urban, Wilfried Weber, Can Dincer
Summary: Personalized antibiotherapy can maximize efficacy, minimize side effects, and prevent drug resistance. To better integrate therapeutic drug monitoring into clinical practice, a versatile biosensor with an antibody-free assay for on-site testing is introduced. This system offers rapid, low-cost, sample-independent, and multiplexed analysis, which can potentially shift the paradigm of one-size-fits-all strategy.
ADVANCED MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Jason Brandon Katz, Purav Shah, Cesar A. Trillo, Mohammad H. Alshaer, Charles Peloquin, Jorge Lascano
Summary: Cystic fibrosis patients with pulmonary exacerbations who received therapeutic drug monitoring of beta-lactams experienced decreased exacerbations, longer intervals to exacerbation, and a lower decline in lung function (FEV1% predicted).
RESPIRATORY MEDICINE
(2023)
Letter
Critical Care Medicine
Mohd H. Abdul-Aziz, Kiran Shekar, Jason A. Roberts
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Isabel Spriet, Jan J. De Waele
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Correction
Pharmacology & Pharmacy
Amy Legg, Niamh Meagher, Sandra A. Johnson, Matthew A. Roberts, Alan Cass, Marc H. Scheetz, Jane Davies, Jason A. Roberts, Joshua S. Davis, Steven Y. C. Tong
CLINICAL DRUG INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Eko Setiawan, Menino Osbert Cotta, Mohd-Hafiz Abdul-Aziz, Doddy Widjanarko, Hernycane Sosilya, Dwi Lily Lukas, Steven C. Wallis, Suzanne Parker, Jason A. Roberts
Summary: This study investigated the pharmacokinetics of ampicillin-sulbactam in patients with a wide range of renal functions and found that serum creatinine was closely associated with drug clearance. Furthermore, a 4-hour infusion was found to enhance the probability of target attainment and fractional target attainment, especially at higher minimum inhibitory concentrations.
CLINICAL PHARMACOKINETICS
(2023)
Review
Pharmacology & Pharmacy
Haifa Lyster, Kiran Shekar, Kevin Watt, Anna Reed, Jason A. A. Roberts, Mohd-Hafiz Abdul-Aziz
Summary: Extracorporeal membrane oxygenation (ECMO) is an advanced life support system that provides temporary cardiac and/or respiratory support for critically ill patients. Fungal infections are associated with higher mortality rates in patients on ECMO. The pharmacokinetics of antifungal drugs can be affected by critical illness and ECMO, making dosing challenging. Current literature on antifungal dosing in critically ill patients on ECMO is limited and inconsistent, making it necessary to consider therapeutic drug monitoring.
CLINICAL PHARMACOKINETICS
(2023)
Review
Infectious Diseases
Jason A. Roberts, Katherine Croom, Nicholas Adomakoh
Summary: Continuous infusion of beta-lactam antibiotics may be beneficial in some patients, especially those with severe infections. However, the existing studies have been small-scale and have yielded conflicting results. The best evidence on the clinical outcomes of beta-lactam continuous infusion comes from systematic reviews/meta-analyses.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Editorial Material
Critical Care Medicine
Jan J. J. De Waele, Isabel Leroux-Roels, Pieter Depuydt
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
Thomas De Corte, Jarne Verhaeghe, Sofie Dhaese, Sarah Van Vooren, Jerina Boelens, Alain G. Verstraete, Veronique Stove, Femke Ongenae, Liesbet De Bus, Pieter Depuydt, Sofie Van Hoecke, Jan J. De Waele
Summary: This study evaluated the pathogen-based clinically relevant target attainment of piperacillin-tazobactam and meropenem in surgical ICU patients. Despite achieving better results in the pathogen-based scenario compared to the worst-case scenario, a substantial proportion of samples did not attain commonly used PK/PD targets.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Wim Vandenberghe, Jorien De Loor, Katrien Francois, Kristof Vandekerckhove, Ingrid Herck, Johan Vande Walle, Harlinde Peperstraete, Thierry Bove, Daniel De Wolf, Lieve Nuytinck, Jan J. De Waele, Evelyne Meyer, Eric A. J. Hoste
Summary: This study evaluated serum CHI3L1, NGAL, TIMP-2, IGFBP7, and NephroCheck(R) as predictors of acute kidney injury (AKI) after pediatric cardiac surgery. The results showed that these markers could reliably predict the occurrence of AKI within 48 hours and 12 hours, respectively, after adjusting for urine dilution.
Article
Infectious Diseases
Andrew Burke, Robyn Carter, Carla Tolson, Jacob Congdon, Christine Duplancic, Evan Bursle, Scott C. Bell, Jason A. Roberts, Rachel Thomson
Summary: This study describes the in vitro activity of imipenem-relebactam and tedizolid against Mycobacterium abscessus isolates from patients with and without cystic fibrosis, and suggests their potential use as treatment options for M. abscessus infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Computer Science, Information Systems
Jarne Verhaeghe, Thomas De Corte, Christopher M. Sauer, Tom Hendriks, Olivier W. M. Thijssens, Femke Ongenae, Paul Elbers, Jan De Waele, Sofie Van Hoecke
Summary: This study developed risk models for atrial fibrillation (AF) in intensive care unit (ICU) patients using uncertainty quantification. The models showed good performance and accurate prediction of AF risk in multiple ICU datasets.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Infectious Diseases
Daniel Fresan, Sonia Luque, Adela Benitez-Cano, Luisa Sorli, Maria Milagro Montero, Marta De-Antonio, Victoria Vega, Jason A. Roberts, Juan P. Horcajada, Santiago Grau
Summary: This study describes the use of therapeutic drug monitoring (TDM) and pharmacokinetics/pharmacodynamics (PK/PD) target attainment of ceftaroline administered by intermittent and prolonged infusion in patients with MDR-GP bacterial infections. The results show that patients treated with prolonged infusions achieved the PK/PD target.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Srinivas Sulugodu Ramachandra, Fekade Bruck Sime, Saiyuri Naicker, Pingping Han, Ryan S. B. Lee, Steven Wallis, Jason A. Roberts, Saso Ivanovski
Summary: This study investigated the antimicrobial effect of amoxicillin on polymicrobial microcosm biofilms derived from subgingival plaque using an in vitro dynamic bioreactor model. The results showed that amoxicillin had a significant antimicrobial effect on the biofilms and could reduce/eliminate certain bacteria.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemical Research Methods
Santosh K. S. Adiraju, Chandra D. Sumi, Saurabh Pandey, Menino O. Cotta, Jason A. Roberts, Jeffrey Lipman, Steven C. Wallis, Suzanne L. Parker
Summary: A methodology for measuring levetiracetam in plasma and urine was developed, validated, and applied to a clinical pharmacokinetic study in critically ill patients with severe traumatic brain injury. The method is suitable for measuring levetiracetam concentrations in human plasma and urine, and it can be used to study the pharmacokinetics of levetiracetam in patients with severe traumatic brain injury.
Article
Microbiology
Maria Patricia Hernandez-Mitre, Steven C. Wallis, Elizabeth E. Morgan, Michael N. Dudley, Jeffery S. Loutit, David C. Griffith, Jason A. Roberts, Ryan K. Shields
Summary: This phase I clinical trial investigated the pharmacokinetics, safety, and tolerability of ceftibuten. The study found that the exposure of cis- and trans-ceftibuten increased proportionally with increasing doses, and accumulation of ceftibuten was observed. Ceftibuten was well tolerated at doses up to 800 mg twice-daily.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
