Review
Public, Environmental & Occupational Health
Francisca Verdugo-Paiva, Fernando Otaiza, Pablo Roson-Rodriguez, Ana Maria Rojas-Gomez, Marcelo Galas, Nathalie El Omeiri, Yackelin Fuentes, Gabriel Rada, Pilar Ramon-Pardo
Summary: This systematic review aims to summarize the evidence on the effects of screening strategies to detect carbapenem-resistant gram-negative bacteria. The review found that there was a decline in the prevalence of infection and colonization rates after the implementation of active surveillance, but the quality of the evidence was low. Screening strategies may not have a significant impact on all-cause mortality risk and length of hospital stay. More high-quality studies are needed to improve the certainty of the existing evidence.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Review
Immunology
Shio-Shin Jean, Dorji Harnod, Po-Ren Hsueh
Summary: Infections caused by multidrug-resistant Gram-negative bacteria have become a major challenge to public health. Hospitals and healthcare institutions face significant economic burden in controlling the spread of these bacteria. Some antibiotics have shown effectiveness against these resistant strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Nowrosh Islam, Misha Kazi, Katie N. Kang, Jacob Biboy, Joe Gray, Feroz Ahmed, Richard D. Schargel, Cara C. Boutte, Tobias Dorr, Waldemar Vollmer, Joseph M. Boll
Summary: Beta-lactam antibiotics disrupt the peptidoglycan layer of bacteria, leading to lysis and death. Many Gram-negative bacteria show tolerance to bactericidal antibiotics, which is associated with treatment failure and the development of true resistance. This study investigates the tolerance mechanisms of Acinetobacter baumannii, a multidrug-resistant pathogen. The findings suggest that outer membrane integrity and peptidoglycan recycling play significant roles in meropenem tolerance in A. baumannii.
Review
Microbiology
Sanket Shah, Ritam Das, Bhakti Chavan, Urmi Bajpai, Sarmad Hanif, Syed Ahmed
Summary: The indiscriminate use of antibiotics has led to a rise in antimicrobial resistance (AMR), posing a serious global threat. Natural or engineered phage-encoded lysins (enzybiotics) show promise as alternative antibacterial agents. While there have been advancements in using lysins against Gram-positive bacteria, the outer membrane of Gram-negative bacteria presents a challenge. This review discusses the potential and challenges of lysins, particularly for priority Gram-negative pathogens, and the regulatory framework for developing them as therapeutics.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Sara Alosaimy, Taylor Morrisette, Abdalhamid M. Lagnf, Leonor M. Rojas, Madeline A. King, Benjamin M. Pullinger, Athena L. Hobbs, Nicholson B. Perkins, Michael P. Veve, Jeannette Bouchard, Tristan Gore, Bruce Jones, James Truong, Justin Andrade, Glen Huang, Reese Cosimi, S. Lena Kang-Birken, Kyle C. Molina, Mark Biagi, Michael Pierce, Marco R. Scipione, Jing J. Zhao, Susan L. Davis, Michael J. Rybak
Summary: This study investigated the treatment of patients with Acinetobacter baumannii infections using Eravacycline (ERV), with the majority of isolates being carbapenem resistant. The results showed that patients treated with ERV combination therapy had a 30-day mortality rate of 23.9% and a low incidence of possible adverse events.
MICROBIOLOGY SPECTRUM
(2022)
Article
Public, Environmental & Occupational Health
Jiwon Jung, Joung Ha Park, Hyejin Yang, Young-Ju Lim, Eun Ok Kim, Chae-Man Lim, Mi-Na Kim, Min-Woo Jo, Sung-Cheol Yun, Sung-Han Kim
Summary: This pragmatic study conducted in South Korea's adult ICU settings examined the effectiveness of active screening, preemptive isolation, and contact precautions in reducing transmission of CRGNB. The results suggest that active surveillance testing and preemptive isolation could be considered in settings with high baseline prevalence of CRGNB.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Immunology
Anke Breine, Megane Van Gysel, Mathias Elsocht, Clemence Whiteway, Chantal Philippe, Theo Quinet, Adam Valcek, Johan Wouters, Steven Ballet, Charles Van der Henst
Summary: This article investigates the issue of carbapenem-resistant Acinetobacter baumannii bacteria and identifies a compound with inhibitory activity against these strains.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jose Raul Nieto-Saucedo, Luis Esau Lopez-Jacome, Rafael Franco-Cendejas, Claudia Adriana Colin-Castro, Melissa Hernandez-Duran, Luis Raul Rivera-Garay, Karina Senyase Zamarripa-Martinez, Juan Luis Mosqueda-Gomez
Summary: The prevalence of carbapenem-resistant Gram-negative bacilli (CR-GNB) and the frequency of carbapenemase-encoding genes were evaluated in a tertiary referral center in El Bajio, Mexico. Among 508 Gram-negative bacilli, 37 were carbapenem-resistant (7.3%), and only 15 (40.5%) of them carried carbapenemase-encoding genes.
Article
Infectious Diseases
Himanshu Jangid, Deepak Kumar, Gaurav Kumar, Raj Kumar, Narsimha Mamidi
Summary: This review paper presents a comprehensive bibliometric analysis of global scientific research on carbapenem-resistant Acinetobacter baumannii (CRAB) from 1996 to 2023. The analysis reveals the earliest publication in the CRAB research domain in 1996 and provides valuable insights into the evolution of research themes and emerging areas of interest. It highlights that China has the highest quantity of published research articles in this field, while the United States has the most citations in CRAB research. The study emphasizes the need for collaborative initiatives to address the challenges posed by this antibiotic-resistant pathogen.
Article
Microbiology
Giancarlo Ceccarelli, Francesco Alessandri, Sonia Moretti, Alessandra Borsetti, Maria Teresa Maggiorella, Silvia Fabris, Alessandro Russo, Franco Ruberto, Daniele De Meo, Massimo Ciccozzi, Claudio M. Mastroianni, Mario Venditti, Francesco Pugliese, Gabriella D'Ettorre
Summary: This study assessed the risk factors for CR-GNB colonization and the clinical impact of colonization in severe trauma patients. The results showed a strong association between ICU stay duration, mechanical ventilation duration, previous colonization, and the risk of colonization. Additionally, factors such as higher comorbidity index and longer duration of treatment were associated with infection in colonized patients.
Article
Biotechnology & Applied Microbiology
Marius Muller, Andrea Wiencierz, Christian Gehringer, Veronika Muigg, Stefano Bassetti, Martin Siegemund, Vladimira Hinic, Sarah Tschudin-Sutter, Adrian Egli
Summary: This study aims to identify risk factors for and the clinical impact of infections caused by non-beta-lactamase mediated carbapenem-resistant bacteria. The duration of prior carbapenem treatment was found to be a strong risk factor for the development of carbapenem resistance, but there was no strong evidence for the clinical implications of resistance or increased mortality.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mei-Chun Lee, Hsun Chang, Fang-Ju Sun, Alice Ying-Jung Wu, Chien -Hung Lu, Chun -Ming Lee
Summary: This study focuses on the association between carbapenem-resistant Enterobacteriales and antimicrobial consumption in Taiwan. The findings reveal an increase in the consumption of piperacillin/tazobactam, fluoroquinolones, meropenem, and doripenem, and a decrease in the consumption of aminoglycosides and imipenem/cilastatin. The prevalence of carbapenem-resistant Klebsiella pneumoniae (CRKP) rose over time and correlated positively with the consumption of certain antibiotics. Both CRKP and carbapenem-resistant Escherichia coli (CREC) prevalence were negatively correlated with aminoglycosides consumption.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Infectious Diseases
Matteo Piccica, Michele Spinicci, Annarita Botta, Vincenzo Bianco, Filippo Lagi, Lucia Graziani, Alessandro Faragona, Roberto Parrella, Tommaso Giani, Andrea Bartolini, Gianluca Morroni, Mariano Bernardo, Gian Maria Rossolini, Marcello Tavio, Andrea Giacometti, Alessandro Bartoloni
Summary: Real-life data confirm that cefiderocol is a promising option against carbapenem-resistant Gram-negative infections, even as monotherapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Dee Shortridge, Jennifer M. Streit, Rodrigo Mendes, Mariana Castanheira
Summary: Cefiderocol is a broad-spectrum cephalosporin with activity against Gram-negative bacteria, making it a valuable therapeutic option for drug-resistant infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Abera Abdeta, Adane Bitew, Surafel Fentaw, Estifanos Tsige, Dawit Assefa, Tadesse Lejisa, Yordanos Kefyalew, Eyasu Tigabu, Martin Evans
Summary: The study detected a high prevalence of multidrug-resistant and extremely drug-resistant carbapenemase-producing gram-negative bacteria, particularly among intensive care unit patients at healthcare facilities. This highlights the increasing difficulty in clinical management of infected patients and the need for last-resort antibiotics, potentially worsening the global antimicrobial resistance crisis. Robust antimicrobial resistance monitoring and infection prevention and control programs are necessary.
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)