期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 37, 期 1, 页码 16-21出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2010.09.012
关键词
CTX-M-14; Extended-spectrum beta-lactamase; ESBL; Escherichia coli; MLST; ExPEC
资金
- Agencia Espanola de Cooperacion Internacional (AECI)
- Spanish Ministerio de Asuntos Exteriores y Cooperacion
- Instituto de Salud Carlos III del Ministerio de Ciencia e Innovacion, Fondo de Investigacion Sanitaria [PI020918, REIPI RD06/0008/1018-0025-1016, PS09/01273, PI081368, PS09/00687]
- Ministerio de Ciencia e Innovacion [AGL-2008-02129]
- Xunta de Galicia [09TAL007261PR, 2007/000044-0]
- European Regional Development Fund (ERDF)
CTX-M enzymes, mainly CTX-M-14 and CTX-M-15, have emerged as the most prevalent extended-spectrum beta-lactamase (ESBL) type produced by Escherichia coli in Spain, with successful dissemination of clonal group O25b:H4-B2-ST131 producing CTX-M-15 within the hospital and community settings. However, until now CTX-M-14-producing E. coli in Spain had been shown to belong to a wide variety of serotypes with no predominance of a certain clonal group. In the present study, 654 E. coli strains positive for ESBL production obtained between 2005 and 2008 from inpatients and outpatients of four hospitals in Galicia, northwest Spain, were analysed. The strains were characterised with regard to ESBL enzymes, serotype, virulence genes, phylogenetic group, multilocus sequence type, and pulsed-field gel electrophoresis of XbaI-digested DNA. As a result, the emergence of certain clonal groups of extraintestinal pathogenic E. coli producing CTX-M-14 has been detected in this geographic area, including O1:HNM-D-ST59, O15:H1-D-ST393/ST1394, O20:H34/HNM-D-ST354, O25b: H4-B2-ST131 and ONT:H21,42-B1-ST101. These five clonal groups showed a high virulence potential as they harboured more than eight virulence factors, which could explain their successful dissemination. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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