Article
Infectious Diseases
Chailat Maluangnon, Surat Tongyoo, Chairat Permpikul
Summary: This study compared the benefits of continuous and intermittent vancomycin infusion. Continuous infusion was found to achieve therapeutic targets faster and have fewer subtherapeutic episodes compared to intermittent infusion. However, there was no significant difference in treatment success, mortality, or incidence of acute kidney injury between the two methods.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Jinhui Xu, Lufen Duan, Jiahui Li, Fang Chen, Xiaowen Xu, Jian Lu, Zhiwei Zhuang, Yifei Cao, Yunlong Yuan, Xin Liu, Jiantong Sun, Qin Zhou, Lu Shi, Lian Tang
Summary: This prospective interventional study compared the pharmacokinetic/pharmacodynamics (PK/PD) target attainment, therapeutic efficacy, and safety between critically ill patients receiving continuous infusion (CI) or intermittent infusion (II) of vancomycin during continuous venovenous hemofiltration (CVVH). The study also explored the correlations between effluent flow rate (EFR) and PK/PD indices.
BMC INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
S. G. Passon, A. R. Schmidt, M. Wittmann, M. Velten, T. Baehner
Summary: Continuous infusion of ampicillin/sulbactam in critically ill patients showed therapeutic concentrations exceeding the minimum inhibitory concentration (MIC) breakpoint in all measurements and above the 4-fold MIC in the majority of analyses. However, patients with acute kidney injury had significantly higher serum concentrations, while impaired renal function and increased renal clearance affected drug levels.
Article
Multidisciplinary Sciences
Christina Medhat Naiim, M. M. Elmazar, Nagwa A. Sabri, Naglaa S. Bazan
Summary: This study compared the efficacy, safety, and cost-effectiveness between extended infusion and intermittent infusion of piperacillin/tazobactam in the treatment of gram-negative bacterial infections. The results demonstrated that extended infusion had shorter treatment duration and time to clinical success compared to intermittent infusion, and it was more cost-effective. Both regimens had comparable clinical and microbiological outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Uwe Liebchen, Hanna Salletmeier, Simon Kallee, Christina Scharf, Lucas Huebner, Alexandra Weber, Michael Zoller
Summary: This study aimed to investigate the optimal loading doses of meropenem before continuous infusion in critically ill patients, recommending a loading dose of 0.5 g in extreme scenarios for better target attainment following continuous infusion.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Romain Garreau, Benoit Falquet, Lisa Mioux, Laurent Bourguignon, Tristan Ferry, Michel Tod, Florent Wallet, Arnaud Friggeri, Jean-Christophe Richard, Sylvain Goutelle
Summary: This study conducted population pharmacokinetic analysis to identify optimal loading and maintenance doses of vancomycin administered by continuous infusion in ICU patients. The model-driven approach suggested loading dose of 27.5 mg/kg of ideal body weight and maintenance dose ranging from 17.5 to 30 mg/kg depending on renal function. Simulations showed that approximately 55.8% of patients would achieve the target exposure with the suggested dosages.
Article
Endocrinology & Metabolism
Eileen R. Faulds, Andrew Boutsicaris, Lyndsey Sumner, Laureen Jones, Molly McNett, Keaton S. Smetana, Casey C. May, Elizabeth Buschur, Matthew C. Exline, Matthew D. Ringel, Kathleen Dungan
Summary: This study provides data to support the feasibility, accuracy, safety, and potential workload reduction of using CGM with a hybrid protocol in the ICU for patients with COVID-19 on IV insulin therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Infectious Diseases
Ligia-Ancuta Hui, Constantin Bodolea, Laurian Vlase, Elisabeta Ioana Hiriscau, Adina Popa
Summary: A judicious antibiotic therapy is essential for critically ill patients with sepsis and septic shock. Understanding the pharmacokinetics and pharmacodynamics of antibiotics, particularly linezolid, is crucial for achieving therapeutic goals and minimizing side effects in intensive care settings.
Article
Infectious Diseases
Sarah Tournayre, Olivier Mathieu, Maxime Villiet, Noemie Besnard, Vincent Brunot, Delphine Daubin, Laura Platon, Philippe Corne, Kada Klouche, Romaric Larcher
Summary: This retrospective cohort study compares the plasma concentrations of meropenem achieved with continuous infusion and extended intermittent infusion in ICU patients, finding that continuous infusion is more effective in achieving the target concentration.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Pharmacology & Pharmacy
Julia E. Mohlmann, Matthijs van Luin, Esther V. Uijtendaal, Noel Zahr, Maaike A. Sikma
Summary: This study presents a case of using cefiderocol as continuous infusion to treat a critically ill patient with multidrug-resistant Pseudomonas aeruginosa infection. The results suggest that continuous infusion can achieve the desired drug concentrations for effective treatment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Giuliano Ramadori
Summary: SARS-CoV-2 infection leads to hypercoagulation and hypoalbuminemia, with albumin infusion playing a crucial role in improving hemodynamics and reducing the risk of thrombosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xiangqing Song, Mi Han
Summary: This study evaluated the PK/PD exposure of vancomycin in MRSA bloodstream infections using different infusion modes. The results showed that the optimal two-step infusion (OTSI) mode had advantages in terms of both efficacy and safety, especially for patients with a creatinine clearance (CLcr) of >= 60 ml/min and isolates with an MIC of <= 2 mg/L.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Sonia Luque, Adela Benitez-Cano, Leire Larranaga, Luisa Sorli, Maria Eugenia Navarrete, Nuria Campillo, Jesus Carazo, Isabel Ramos, Ramon Adalia, Santiago Grau
Summary: In critically ill patients treated with meropenem by extended or continuous infusion, there were no significant differences in drug exposure levels between patients with low body weight and normal body weight. The only factor independently associated with supratherapeutic drug exposure was a baseline estimated glomerular filtration rate (eGFR) < 90 mL/min.
Article
Infectious Diseases
Dong-gon Hyun, Jarim Seo, Su Yeon Lee, Jee Hwan Ahn, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
Summary: This study retrospectively compared the survival benefits of continuous vs. intermittent infusion of piperacillin-tazobactam in sepsis patients, showing that patients in the continuous group had significantly lower mortality at 28 days compared to those in the intermittent group.
Article
Pharmacology & Pharmacy
Ji-Yeon Bang, Hyun Il Kang, Hak-Jae Lee, Yong Pil Chong, Suk-Kyung Hong, Eun-Kyung Lee, Byung-Moon Choi, Gyu-Jeong Noh
Summary: This study aimed to construct a new pharmacokinetic model of vancomycin for target-concentration controlled infusion (TCI). The results showed that the TCI method maintained therapeutic concentration range the longest and reduced the dose by about 15% compared to standard administration methods, making it suitable for patient-tailored dosing in critically ill patients.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
