Article
Infectious Diseases
Joshua R. Watson, Cynthia Burch, Amy L. Leber
Summary: The susceptibility of urine isolates of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis to cefazolin can predict susceptibility to oral cephalosporins, with cefazolin-resistant isolates potentially still being susceptible to oral third generation cephalosporins. There is over 95% categorical agreement among oral third-generation cephalosporins in 194 urine isolates, and surrogate testing of cefpodoxime for cefdinir showed no major errors.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Shazad Mushtaq, Anna Vickers, Aiysha Chaudhry, Neil Woodford, David M. Livermore
Summary: The study found that combinations of PBP3-active beta-lactams with DBOs like zidebactam remain active against many MBL producers, but this activity is influenced by inoculum levels. MIC values for MBL producers were strongly dependent on inoculum, while non-MBL isolates showed less dependence on inoculum levels.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Andre Birgy, Fouad Madhi, Camille Jung, Corinne Levy, Aurelie Cointe, Philippe Bidet, Claire Amaris Hobson, Stephane Bechet, Elsa Sobral, Hoang Vuthien, Agnes Ferroni, Said Aberrane, Gaelle Cuzon, Laetitia Beraud, Vincent Gajdos, Elise Launay, Didier Pinquier, Herve Haas, Marie Desmarest, Marie-Aliette Dommergues, Robert Cohen, Stephane Bonacorsi
Summary: The study investigated the impact of beta-lactamases and Enterobacterales' genotypes on the MICs of cefixime, cefpodoxime, mecillinam alone and combined with amoxicillin/clavulanate. The results showed that most isolates were resistant to cefixime and cefpodoxime, but susceptibility was restored with the addition of amoxicillin/clavulanate, indicating potential clinical efficacy. The in vivo efficacy of cefixime + amoxicillin/clavulanate combination therapy was satisfactory, even in cases of initial treatment failure, suggesting it as a viable option for FUTIs.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Chemistry, Medicinal
Tuba Recber, Ece Ozkan, Emirhan Nemutlu, Sedef Kir
Summary: In this study, two cephalosporin groups of antibiotics were simultaneously analyzed by HPLC method, showing specific, linear, sensitive, accurate, precise, and robust results. The method was successfully applied to two combined pharmaceutical dosage forms containing cephalosporin antibiotics and clavulanic acid.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Article
Environmental Sciences
S. Balasurya, Mohammad K. Okla, Hamada AbdElgawad, Abdullah A. AL-ghamdi, Mostafa A. Abdel-Maksoud, Saud S. Al-Amri, Mahmoud M. Y. Madany, S. Sudheer Khan
Summary: The study presents an innovative approach for sunlit driven heterostructure photocatalytic generation of H2O2 and removal of cefixime. This was achieved through the use of Mn/Mg doped CoFe2O4 modified CaCr2O4 deco-rated by Ag3PO4 quantum dots (Ag3PO4 QDs), which formed a p-n-p nano heterojunction. The study highlights the robust activity of the nano heterojunction and its significance for sustainable water treatment.
Article
Infectious Diseases
Cecile Emeraud, Alexandre Godmer, Delphine Girlich, Oceane Vanparis, Feriel Mahamdi, Elodie Creton, Agnes B. Jousset, Thierry Naas, Remy A. Bonnin, Laurent Dortet
Summary: The study evaluated the susceptibility of mecillinam against various CRE strains, showing higher susceptibility rates for certain Enterobacterales species. However, lower susceptibility rates were observed for other species such as Klebsiella pneumoniae and Enterobacter cloacae complex. Mecillinam may be a potential alternative for treating CRE infections, particularly UTIs.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Niels Frimodt-Moller, Gunnar Skov Simonsen, Anders Rhod Larsen, Gunnar Kahlmeter
Summary: Despite easily developing resistance in vitro, pivmecillinam is widely used for treating urinary tract infections in primary care in Denmark, Norway, and Sweden without an increase in resistance rates.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Jonas Bredtoft Boel, Valeria Antsupova, Jenny Dahl Knudsen, Jens Otto Jarlov, Magnus Arpi, Barbara Juliane Holzknecht
Summary: The study suggests that IV mecillinam may be a suitable targeted treatment for bacteraemia with a urinary tract focus, but these results need confirmation by randomized controlled studies.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Aanchal Gupta, Saquib Malik, Monica Kaminski, David Landman, John M. Quale
Summary: The combination of amoxicillin-clavulanate with ceftibuten or cefpodoxime can effectively kill bacteria producing ESBL, regardless of the type of ESBL and the minimal inhibitory concentration of cephalosporin. This combination therapy can improve the survival rate of infected patients, but further clinical studies are needed to validate its efficacy.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Chemistry, Physical
Kaimin Wang, Yanqiu Dong, Xuling Bai, Xiong Zhao, Ruiting Zhao, Jie Zhou, Hongmei Yu, Lifeng Li, Huaijun Tang, Yulu Ma
Summary: A new Zn (II) coordination polymer, {[Zn(dia)(bpeh)]・3H2O}(CP1), was synthesized and used as a fluorescence sensor with excellent properties for selectively and sensitively identifying Cefixime (CFM) antibiotic in aqueous solutions. CP1 is also the first fluorescent probe material capable of detecting CFM antibiotic in multiple food samples. The fluorescence quenching mechanism is attributed to the internal filtration effect and photoelectron electron transfer.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Engineering, Environmental
B. Harikumar, S. Sudheer Khan
Summary: In this study, a ternary nanocomposite was fabricated and characterized for the efficient degradation of antibiotics under visible light irradiation. The photodegradation efficiency and mechanism were investigated, and the toxicity of the degraded end products was evaluated. The study provides new insights into the remediation of pharmaceutical pollutants using the fabricated photocatalyst.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
S. Balasurya, Abdallah M. Elgorban, Ali H. Bahkali, M. T. Yassin, R. Balakrishnaraja, Rajender S. Varma, Asad Syed, S. Sudheer Khan
Summary: This study investigated the photocatalytic remediation of antibiotics in water using CuCr2O4-BiI3O9 nanocomposite. The results showed that the nanocomposite achieved a 98.2% removal rate of cefixime under visible light irradiation. Furthermore, the nanocomposite exhibited excellent photostability and reusability, and showed no genotoxicity to plant cells.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Shashikant Srivastava, Tania Thomas, Dave Howe, Lesibana Malinga, Prithvi Raj, Jan-Willem Alffenaar, Tawanda Gumbo
Summary: The study showed that cefdinir has potential efficacy against both drug-susceptible and multi-drug resistant tuberculosis, with the ability to kill Mtb strains in both in vitro and pre-clinical models. The pharmacokinetic/pharmacodynamic index AUC(0-24)/MIC of 578.86 was identified as the optimal exposure for sterilizing efficacy. Further clinical validation of these findings is needed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Thi Thuy Trang Truong, Thi Ngan Vu, Thi Diu Dinh, Thu Thao Pham, Thi Anh Huong Nguyen, Manh Ha Nguyen, The Dung Nguyen, Shin-ichi Yusa, Tien Duc Pham
Summary: The study investigates the adsorption of a strong polycation, PMAPTAC, on nanosilica extracted from rice husk for the removal of beta-lactam cefixime (CEF). The pre-adsorption of PMAPTAC on nano-SiO2 dramatically enhances CEF removal, resulting in a new adsorbent named PCNS. Optimization of parameters such as time, dosage, pH, and concentration led to successful CEF removal by PCNS, with a pseudo-second-order kinetics model fitting the adsorption process. The hybrid adsorbent PMAPTAC coated nano-SiO2 shows promising results for antibiotic removal from wastewater, even after multiple reuses.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Pharmacology & Pharmacy
Shashikant Srivastava, Kayle N. Cirrincione, Devyani Deshpande, Tawanda Gumbo
Summary: The combination of tedizolid, moxifloxacin, and faropenem showed effective killing of nonreplicating persisters (NRP) of Mycobacterium tuberculosis. There was no significant difference in efficacy compared to the standard TB regimen, and no emergence of drug resistance was observed in the study. Further clinical studies are needed to validate these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)