Article
Microbiology
Weiliang Zeng, Xiaotuan Zhang, Yan Liu, Yi Zhang, Mengxin Xu, Sipei Wang, Yao Sun, Tieli Zhou, Lijiang Chen
Summary: This study investigated the activity and resistance mechanisms of new generation tetracycline agents against Staphylococcus aureus isolates. The results showed that eravacycline and tigecycline exhibited better antibacterial activity than omadacycline. Tetracycline-resistant isolates possessed multiple resistance mechanisms, including genetic mutations and efflux pump expression.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Parnrada Nulsopapon, Worapong Nasomsong, Manat Pongchaidecha, Dhitiwat Changpradub, Piraporn Juntanawiwat, Wichai Santimaleeworagun
Summary: The study on antibiotic sensitivity and pharmacokinetic/pharmacodynamic data of CRKP and CoRKP suggests that increasing antibiotic treatment doses and combination therapy may be effective strategies against these bacteria.
Article
Microbiology
David R. Snydman, Laura McDermott
Summary: The study evaluated the activity of Aztreonam-avibactam against 341 recent clinical isolates, showing that the drug lacks activity against anaerobic organisms.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Srijita Basak, Debashrito Deb, Utkarsh Narsaria, Tamalika Kar, Filippo Castiglione, Indraneel Sanyal, Pratap D. Bade, Anurag P. Srivastava
Summary: Clostridium difficile infection is a major health-associated infection with high incidence and mortality rates. A chimeric vaccine candidate was designed using immunoinformatics, which showed stability and reliability in silico and molecular dynamics simulations. Docking studies demonstrated stable interactions with immune receptors, and in silico modeling indicated competent expression in E. coli system for potential immune response.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Xi-Wang Liu, Ya-Jun Yang, Zhe Qin, Shi-Hong Li, Li-Xia Bai, Wen-Bo Ge, Jian-Yong Li
Summary: This study investigated the antibacterial activity of the active component IBCL from traditional Chinese herb medicine Cullen corylifolium against Clostridium difficile. Results showed that IBCL effectively killed the bacteria by disrupting the cell membrane integrity, reducing weight loss associated with CDI infections.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Jeongwoo Jo, Kwan Soo Ko
Summary: The study on Acinetobacter baumannii isolates from South Korea revealed a high prevalence of tigecycline heteroresistance, mainly attributed to the overexpression of AdeABC efflux pumps due to ISAba1 insertion in adeS. Resistance was found to be unstable in an antibiotic-free environment, with potential for reversion to susceptibility through additional mutations.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biotechnology & Applied Microbiology
Meng Wang, Zifeng Deng, Yanmei Li, Yi Ma, Jufang Wang
Summary: A novel lytic protein Cw1-CWB2 with high binding specificity and strong lytic activity has been designed in this study for combating C. difficile.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Nezar M. Bahabri, Maha Mahmoud Al-Alawi, Mohammed O. Qutub, Wail A. Tashkandi, Raha AlTurki, Safiah Saad Janah, Heidi Essam Ali, Albandari F. Almutairi, Sherif Khalil
Summary: The susceptibility of recently collected bacterial isolates to ceftolozane/tazobactam (C/T) and other antibiotics was investigated. The study found that C/T displayed high potency against all examined bacterial isolates, with the highest susceptibility observed in E.coli.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Bing Bai, Chengchun Chen, Yuxi Zhao, Guangjian Xu, Zhijian Yu, Vincent H. Tam, Zewen Wen
Summary: The study examined the in vitro activities of tigecycline (TGC) and the mechanisms of TGC stress response and resistance in clinical Enterococcus faecalis isolates from China. TGC showed excellent activity against a substantial proportion of clinical isolates, but E. faecalis exhibited strong adaptation mechanisms during TGC exposure, resulting in TGC resistance through mutation of TGC target sites and elevated expression of efflux pumps.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Alessandra Pino, Tommaso Mazza, Maura-Ann H. Matthews, Stefano Castellana, Cinzia Caggia, Cinzia L. Randazzo, Gary A. Gelbfish
Summary: Gardnerella species are key players in the development and recurrence of Bacterial Vaginosis (BV), often showing high resistance to antibiotics. Bovine lactoferrin may be a potential candidate for treating Gardnerella species infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Ha-Young Choi, Bo-Min Kim, Young-Rok Kim, Taehui Yang, Sunjoo Ahn, Dongeun Yong, Jin-Hwan Kwak, Won-Gon Kim
Summary: The study demonstrates that coralmycin A exhibits potent antibacterial activity against clinical resistant bacteria and shows promising efficacy in animal models, indicating its potential as a new class of antibiotic for treating multidrug-resistant Gram-positive bacterial infections.
Article
Microbiology
Siqi Wang, Leyang Xiang, Fang li, Wenlin Deng, Pinjing Lv, Ye Chen
Summary: This study found that levels of fecal short-chain fatty acids (SCFAs), particularly butyrate, are reduced, and normal colon structure is damaged in patients with CDI compared with those in healthy individuals. Bile acid (BA) metabolic disorder in patients with CDI is characterized by increased primary BA levels and decreased secondary BAs. Butyrate treatment may serve as a novel therapeutic approach for patients with CDI.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Jianwei Chen, Yaojia Lu, Yujie Du, Hong Wang, Qiang Wu
Summary: Clostridioides difficile infection poses a significant threat to human health. Traditional antibiotics are ineffective, necessitating the development of new antibacterial drugs or strategies. Inhibiting virulence or destroying vital physiological structures of C. difficile are promising approaches.
BIOORGANIC CHEMISTRY
(2022)
Article
Immunology
Caixia Tan, Fei Zhu, Yuanyuan Xiao, Yuqi Wu, Xiujuan Meng, Sidi Liu, Ting Liu, Siyao Chen, Juan Zhou, Chunhui Li, Anhua Wu
Summary: In this study, a multi-epitope vaccine against Clostridium difficile was designed using computer methods. The vaccine was able to induce immune response against both spore and propagule forms of the pathogen. The structure of the vaccine was predicted and validated, and its interaction with immune receptors was analyzed through docking and simulation. The findings suggest that the formulated vaccine shows promise against C. difficile, but further research is needed for verification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Charles Darkoh, Kadiatou Keita, Chioma Odo, Micah Oyaro, Eric L. Brown, Cesar A. Arias, Blake M. Hanson, Herbert L. DuPont
Summary: A study found that vancomycin nonsusceptible strains of Clostridioides difficile are circulating in patient populations, posing a serious challenge to treatment as vancomycin is a first-line antibiotic for CDI. Routine susceptibility testing may be necessary.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
