Article
Plant Sciences
Jianyan Qi, Min Gong, Rui Zhang, Yumeng Song, Qian Liu, Hongyan Zhou, Jue Wang, Yufeng Mei
Summary: Tea tree essential oil (TTO) is known for its traditional medicinal uses and earlier research has shown its effectiveness in inhibiting oral microorganisms. This study found that TTO can destroy cell membrane, inhibit biofilm formation, and eliminate mature biofilms of E. faecalis, suggesting its potential as a novel antibacterial drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Marlena Golas-Pradzynska, Magdalena Luszczynska, Jolanta Grazyna Rola
Summary: This study investigates the antimicrobial resistance, virulence, and resistance genes of Enterococcus faecalis and Enterococcus faecium isolated from raw goat's and sheep's milk and cheese. The results show that E. faecalis is the dominant species, with high levels of antimicrobial resistance and presence of virulence genes in some strains.
Article
Microbiology
Alaa Jarkhi, Angeline Hui Cheng Lee, Zhenquan Sun, Mingxin Hu, Prasanna Neelakantan, Xuechen Li, Chengfei Zhang
Summary: The study showed that (L)-Chg(10)-teixobactin exhibited potent antibacterial and antibiofilm effects against Enterococcus faecalis. These findings suggest its potential as an effective antibacterial and antibiofilm agent in endodontic treatment.
Article
Biotechnology & Applied Microbiology
Yingying Xiang, Chunlan Ma, Shuang Yin, Fei Song, Kunhao Qin, Yafang Ding, Xianghong Yang, Pengfei Song, Xiuling Ji, Yunlin Wei
Summary: This study investigated the resistance against Enterococcus faecalis infection using phage therapy and found that phage PEf771 showed significant antibacterial effect and prevention of infection.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Microbiology
Jiazhen Liu, Yanpeng Zhu, Yang Li, Yuwen Lu, Kun Xiong, Qiu Zhong, Jing Wang
Summary: In this study, a bacteriophage EFap02 with the potential for treating drug-resistant Enterococcus faecalis infection was isolated. The phage proved to be tolerant to harsh environments and high temperature. However, phage-resistant mutants were found to have impaired biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Jaclyn A. Cusumano, Kathryn E. Daffinee, Emily C. Piehl, Monica Garcia-Solache, Charlene Desbonnet, Louis B. Rice, Kerry L. LaPlante
Summary: This study explored the use of carbapenems in combination with cephalosporins for the treatment of severe Enterococcus faecalis infections. The results showed that the combination of meropenem and ceftaroline had similar efficacy to the standard treatment and could serve as an alternative for these infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Veterinary Sciences
Sung Hyun Bae, Sunghyun Yoon, Koeun Kim, Yeong Bin Kim, Young Ju Lee
Summary: The study compared chloramphenicol-resistant Enterococcus faecalis isolated from bulk tank milk of four major dairy companies in Korea. Results showed significant differences in antimicrobial resistance genes and the emergence of resistance among the dairy companies, emphasizing the need for effective surveillance programs at a multidisciplinary level.
VETERINARY SCIENCES
(2021)
Article
Infectious Diseases
Sonia Nina Coccitto, Marzia Cinthi, Simona Fioriti, Gianluca Morroni, Serena Simoni, Carla Vignaroli, Cristiana Garofalo, Marina Mingoia, Andrea Brenciani, Eleonora Giovanetti
Summary: This study characterized a linezolid-resistant Enterococcus gallinarum isolate from pigs that carried the cfr, optrA, and poxtA genes. Two plasmids were identified, each carrying different resistance genes. The plasmids showed features of circular intermediates and were not transferable to other enterococcal strains. The persistence of these plasmids in the absence of selective pressure is concerning.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Lara Thieme, Simon Briggs, Eamon Duffy, Oliwia Makarewicz, Mathias W. Pletz
Summary: This study suggests that benzylpenicillin/ceftriaxone is suitable for the treatment of E. faecalis infections with ceftriaxone MIC ≤ 256mg/L, but not for those with ceftriaxone MIC ≥ 512mg/L. Further investigation is needed to analyze the relationship between ceftriaxone susceptibility and penicillin/ceftriaxone synergy.
Article
Microbiology
Xiaoju Liu, Yanpeng Xiong, Yiyi Shi, Xiangbin Deng, Qiwen Deng, Yansong Liu, Zhijian Yu, Duoyun Li, Jinxin Zheng, Peiyu Li
Summary: This study found that licochalcone A has antibacterial effects on Enterococcus faecalis and significantly inhibits biofilm formation. Through genetic mutation analysis, it is suggested that licochalcone A may act by regulating transcription factor genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chunyan Fu, Yuxi Xu, Hao Zheng, Xinyi Ling, Chengzhi Zheng, Leihao Tian, Xiaobin Gu, Jiabei Cai, Jing Yang, Yuanyuan Li, Peiyu Wang, Yuan Liu, Yongliang Lou, Meiqin Zheng
Summary: This study found that diacerein has an inhibitory effect on biofilm formation in drug-resistant E. faecalis strains. The results showed that diacerein can inhibit biofilm formation by suppressing the expression of the esp gene and reducing cell hydrophobicity. In addition, transcriptome analysis revealed that diacerein inhibits bacterial growth and biofilm formation by affecting various metabolic pathways and gene expression.
Article
Infectious Diseases
Lucia Malisova, Vladislav Jakubu, Katarina Pomorska, Martin Musilek, Helena Zemlickova
Summary: The main mechanisms of linezolid resistance in linezolid-resistant enterococci in the Czech Republic were found to be the G2576T mutation in the domain V of 23S rRNA and the presence of the optrA gene, with some isolates also showing resistance to tigecycline and vancomycin.
Article
Agriculture, Dairy & Animal Science
Hyo Jung Kang, Sunghyun Yoon, Koeun Kim, Young Ju Lee
Summary: This study investigated high-level aminoglycoside-resistant Enterococcus faecalis isolated from bulk tank milk in Korea. Most isolates were high-level aminoglycoside resistant and multidrug resistant. Enterococci easily acquired aminoglycoside-resistant genes, requiring advanced management programs by companies to minimize the dissemination of antimicrobial resistance and virulence factors.
Article
Microbiology
Xuying Wu, Wei Fan, Bing Fan
Summary: The study evaluated the synergistic antibacterial activities of silver ions and metformin hydrochloride against Enterococcus faecalis under different conditions, finding that the combination of the two enhanced antibacterial effects, especially on biofilms on dentin slices.
Article
Polymer Science
Jerry Jose, Kavalipurapu Venkata Teja, Krishnamachari Janani, Mohammad Khursheed Alam, Osama Khattak, Mahmoud Gamal Salloum, Shilpa S. Magar, Shaliputra P. Magar, Shanmugam Rajeshkumar, Ajitha Palanivelu, Kumar Chandan Srivastava, Deepti Shrivastava
Summary: The study evaluated the antimicrobial effectiveness of a novel nanocomposite (NC) prepared using a combination of zinc oxide, silver, and chitosan with lemon extract as a cross-linking agent against Enterococcus faecalis (E. faecalis). The NC showed improved antimicrobial action against E. faecalis compared with its individual components under laboratory conditions.
Article
Biochemistry & Molecular Biology
Diego Duchi, Kristofer Gryte, Nicole C. Robb, Zakia Morichaud, Carol Sheppard, Konstantin Brodolin, Sivaramesh Wigneshweraraj, Achillefs N. Kapanidis
NUCLEIC ACIDS RESEARCH
(2018)
Article
Instruments & Instrumentation
A. Baud, L. Ayme, F. Gonnet, I. Salard, Y. Gohon, P. Jolivet, K. Brodolin, P. Da Silva, A. Giuliani, B. Sclavi, T. Chardot, P. Mercere, P. Roblin, R. Daniel
JOURNAL OF SYNCHROTRON RADIATION
(2017)
Article
Microbiology
Emilie Racine, Patrice Nordmann, Lucile Pantel, Matthieu Sarciaux, Marine Serri, Jessica Houard, Philippe Villain-Guillot, Anthony Demords, Carina Vingsbo Lundberg, Maxime Gualtieri
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Lucile Pantel, Tanja Florin, Malgorzata Dobosz-Bartoszek, Emilie Racine, Matthieu Sarciaux, Marine Serri, Jessica Houard, Jean-Marc Campagne, Renata Marcia de Figueiredo, Camille Midrier, Sophie Gaudriault, Alain Givaudan, Anne Lanois, Steve Forst, Andre Aumelas, Christelle Cotteaux-Lautard, Jean-Michel Bolla, Carina Vingsbo Lundberg, Douglas L. Huseby, Diarmaid Hughes, Philippe Villain-Guillot, Alexander S. Mankin, Yury S. Polikanov, Maxime Gualtieri
Article
Multidisciplinary Sciences
David Dulin, David L. V. Bauer, Anssi M. Malinen, Jacob J. W. Bakermans, Martin Kaller, Zakia Morichaud, Ivan Petushkov, Martin Depken, Konstantin Brodolin, Andrey Kulbachinskiy, Achillefs N. Kapanidis
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Rishi Kishore Vishwakarma, Anne-Marinette Cao, Zakia Morichaud, Ayyappasamy Sudalaiyadum Perumal, Emmanuel Margeat, Konstantin Brodolin
Article
Chemistry, Medicinal
Matthieu Sarciaux, Lucile Pantel, Camille Midrier, Marine Serri, Cristelle Gerber, Renata Marcia de Figueiredo, Jean-Marc Campagne, Philippe Villain-Guillot, Maxime Gualtieri, Emilie Racine
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Ayyappasamy Sudalaiyadum Perumal, Rishi Kishore Vishwakarma, Yangbo Hu, Zakia Morichaud, Konstantin Brodolin
NUCLEIC ACIDS RESEARCH
(2018)
Review
Microbiology
Emilie Racine, Maxime Gualtieri
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Einars Loza, Matthieu Sarciaux, Martins Ikaunieks, Martins Katkevics, Tatyana Kukosha, Nadezhda Trufilkina, Victoria Ryabova, Kirill Shubin, Lucile Pantel, Marine Serri, Douglas L. Huseby, Sha Cao, Kavita Yadav, Karin Hjort, Diarmaid Hughes, Maxime Gualtieri, Edgars Suna, Emilie Racine
BIOORGANIC & MEDICINAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Katelyn Knuff-Janzen, Audrey Tupin, Sophie Yurist-Doutsch, Jennifer L. Rowland, B. Brett Finlay
Article
Biochemistry & Molecular Biology
Konstantin Brodolin, Zakia Morichaud
Summary: The study reveals that the absence of the s4 promoter-binding domain renders the RNAP holoenzyme ineffective in de novo transcription initiation. The sigma 4 domain stabilizes short RNA:DNA hybrids, suppresses pausing, and enhances RNAP processivity. The antipausing activity of sigma 4 is modulated by its interaction with other factors, ultimately favoring productive transcription initiation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Nesrine Aissaoui, Josephine Lai-Kee-Him, Allan Mills, Nathalie Declerck, Zakia Morichaud, Konstantin Brodolin, Sonia Baconnais, Eric Le Cam, Jean Baptiste Charbonnier, Remy Sounier, Sebastien Granier, Virginie Ropars, Patrick Bron, Gaetan Bellot
Summary: Technological breakthroughs in electron microscopy have made it possible to study biological macromolecular complexes with novel challenges, such as sample preparation and heterogeneous macromolecular assemblies. In this study, a V-shaped DNA origami template was used to position proteins, demonstrating a new approach for characterizing mechanosensitive proteins and expanding the range of potential targets for single-particle EM investigation. Validation with RNAP protein showed compatibility with cryo-EM sample preparation.
Article
Microbiology
Lucile Pantel, Paulo Juarez, Marine Serri, Lilia Boucinha, Emilie Lessoud, Anne Lanois, Alain Givaudan, Emilie Racine, Maxime Gualtieri
Summary: NOSO-502, a preclinical antibiotic candidate, shows activity against Enterobacteriaceae pathogens but some colistin-resistant bacteria may develop resistance to it, possibly through mutations in the crrB gene. This study highlights the importance of CrrAB in controlling the resistance pathway and the role of the kexD gene in NOSO-502 susceptibility.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Zakia Morichaud, Stefano Trapani, Rishi K. Vishwakarma, Laurent Chaloin, Corinne Lionne, Josephine Lai-Kee-Him, Patrick Bron, Konstantin Brodolin
Summary: Researchers discovered that a stress-response factor called sigma(B) from Mycobacterium tuberculosis can induce the oligomerization of RNA polymerase (RNAP), resulting in the formation of a supramolecular complex composed of eight RNAP units. This finding reveals how sigma(B) can regulate gene expression by modulating the assembly and hibernation of RNAP holoenzyme.
NATURE COMMUNICATIONS
(2023)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
