Article
Microbiology
Mohammad Al-Tamimi, Hadeel Albalawi, Mohamd Alkhawaldeh, Abdullah Alazzam, Hassan Ramadan, Majd Altalalwah, Ahmad Alma'aitah, Dua'a Al Balawi, Sharif Shalabi, Jumana Abu-Raideh, Ashraf Khasawneh, Farah Alhaj, Kamal Hijawi
Summary: This study is the first large-scale, multicenter, and prolonged research on Acinetobacter baumannii infections in Jordan, providing insights into the epidemiology and molecular characteristics of MDR-A. baumannii in the country. Attention to high-risk patients and early identification are crucial. Colistin and tigecycline are the most effective antimicrobials.
Article
Infectious Diseases
In Young Na, Ki Tae Kwon, Kwan Soo Ko
Summary: The study identified nine isolates of Verona integron-encoded metallo-beta-lactamase-2 (VIM-2)-producing Acinetobacter from South Korea, with 8 being Acinetobacter nosocomialis and 1 being Acinetobacter seifertii. Whole-plasmid sequencing indicated clonal dissemination of the VIM-2-producing Acinetobacter nosocomialis isolates, while the plasmid-bearing bla(VIM-2) in Acinetobacter seifertii isolate differed from those in Acinetobacter nosocomialis isolates.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Haiyang Liu, Robert A. Moran, Ying Chen, Emma L. Doughty, Xiaoting Hua, Yan Jiang, Qingye Xu, Linghong Zhang, Jessica M. A. Blair, Alan McNally, Willem van Schaik, Yunsong Yu
Summary: A novel plasmid type, GR34, carrying multiple antibiotic resistance genes was identified in this study. These plasmids are found in various Acinetobacter species in diverse environments, displaying considerable variation in accessory content.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Nouf Al-Rashed, Khalid M. Bindayna, Mohammad Shahid, Nermin Kamal Saeed, Abdullah Darwish, Ronni Mol Joji, Ali Al-Mahmeed
Summary: This study collected 50 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from four main hospitals in Bahrain. The results showed that all isolates were resistant to imipenem, meropenem, and cephalosporins, and harbored various resistance genes. The study emphasizes the importance of strengthening surveillance and stringent infection control measures in clinical settings to prevent the further spread of such isolates.
Article
Biochemistry & Molecular Biology
Sandra Sanchez-Urtaza, Alain Ocampo-Sosa, Ainhoa Molins-Bengoetxea, Jorge Rodriguez-Grande, Mohammed A. El-Kholy, Marta Hernandez, David Abad, Sherine M. Shawky, Itziar Alkorta, Lucia Gallego
Summary: The increasing rates of antimicrobial resistance among carbapenem-resistant Acinetobacter baumannii in the Middle East and North Africa are a major concern. The first A. baumannii isolate with five β-lactamases was identified in Egypt. This isolate exhibited resistance to multiple antibiotics and carried genes associated with virulence and biofilm production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Yuiko Takebayashi, Jacqueline Findlay, Kate J. Heesom, Philip J. Warburton, Matthew B. Avison, Benjamin A. Evans
Summary: Elevated carbapenem MICs were observed by expression of OxaAb variants carrying clinically prevalent substitutions I129L and L167V, requiring overexpression by the upstream ISAba1 promoter. LC-MS/MS analysis confirmed overexpression of these variants, with no other differences in expression levels of proteins commonly associated with carbapenem resistance detected.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
Xinmiao Jia, Peiyao Jia, Ying Zhu, Wei Yu, Xue Li, Jingyuan Xi, Xiaoyu Liu, Kang Liao, Yingchun Xu, Bin Cheng, Qiwen Yang
Summary: We identified a novel hybrid plasmid carrying both bla(NDM-1) and bla(IMP-4) genes, and characterized its genetic and phenotypic features. The plasmid showed potential for horizontal transfer and high stability, without exerting significant growth pressure on bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Clyde A. Smith, Nichole K. Stewart, Marta Toth, Pojun Quan, John D. Buynak, Sergei B. Vakulenko
Summary: The widespread presence of carbapenem-hydrolyzing beta-lactamases in Gram-negative bacteria has reduced the effectiveness of carbapenem antibiotics, limiting treatment options. In the Enterobacteriaceae family, production of class D beta-lactamases, specifically from the OXA-48-type family, is a major mechanism of resistance. This study evaluates a novel carbapenem, NA-1-157, which shows promise in treating infections caused by OXA-48-producing bacterial pathogens.
ACS INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Jacqueline Findlay, Patrice Nordmann, Maxime Bouvier, Auriane Kerbol, Laurent Poirel
Summary: This study investigated the spread and emergence of A. baumannii clones co-producing OXA-23 and ArmA in Switzerland. The majority of the isolates were obtained from infections and belonged to the high-risk GC-2 clone. Monitoring and control of these MDR A. baumannii strains are crucial to prevent further spread.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Hao Guo, Lirong Li, Yanmin Chen, Fang He
Summary: We report the genome sequence of a multidrug-resistant A. bereziniae strain co-carrying bla OXA-301 and bla NDM-1 from China. These findings contribute to understanding the genomic characteristics of this pathogen and are of significance for its future prevalence.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Infectious Diseases
Jee Hong Kim, Yun Young Cho, Ji Young Choi, Yu Mi Wi, Kwan Soo Ko
Summary: This study investigated the characteristics of KPC-2-producing Klebsiella pneumoniae isolates from a hospital in South Korea. It identified two main clones, ST11 and ST307, with different resistance profiles and virulence levels. Continuous monitoring of these clones, which show different characteristics including resistance and virulence, is necessary.
Article
Health Care Sciences & Services
Mohd Saleem, Azharuddin Sajid Syed Khaja, Ashfaque Hossain, Fahaad Alenazi, Kamaleldin B. Said, Soha Abdallah Moursi, Homoud Abdulmohsin Almalaq, Hamza Mohamed, Ehab Rakha
Summary: A 2-year prospective study in a hospital in Saudi Arabia revealed a high prevalence of drug-resistant Acinetobacter baumannii in ventilator-associated pneumonia patients, with a significant increase in incidence rate. The study highlights the importance of strict antibiotic stewardship policies and resistance monitoring.
Article
Microbiology
Jia Li, Yang Li, Xiaoli Cao, Jie Zheng, Yan Zhang, Hui Xie, Chuchu Li, Chang Liu, Han Shen
Summary: Genomic analysis was used to identify Acinetobacter spp. and investigate the distribution of ss-lactamase oxallicinases (blaOXA) globally. OXA-like carbapenemases were found to be the main blaOXA-type beta-lactamase widely spread among Acinetobacter spp. The blaOXA-23 and blaOXA-66 variants were the most frequent, with ST2 (belonging to CC2) being the main clone disseminated globally.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Siquan Shen, Xiangning Huang, Qingyu Shi, Yan Guo, Yang Yang, Dandan Yin, Xun Zhou, Li Ding, Renru Han, Hua Yu, Fupin Hu
Summary: This study reports the first case of a P. rettgeri strain co-harboring bla(NDM-1), bla(VIM-1), and bla(OXA-10). The occurrence of this strain needs to be closely monitored.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Ozlem K. Ozyurt, Ozgul Cetinkaya, Betil Ozhak, Gozde Ongut, Ozge Turhan, Hatice Yazisiz, Levent Donmez, Mert A. Kuskucu, Kenan Midilli, Dilara Ogunc
Summary: The study assessed the performance of the BD Phoenix CPO Detect Test for the detection of carbapenemase-producing Enterobacterales. It found that the test accurately detected carbapenemase production and had a high sensitivity and specificity. This test can be clinically useful for determining treatment options.
FUTURE MICROBIOLOGY
(2023)
Article
Medical Laboratory Technology
Junhyup Song, Shinyoung Yoon, Yongha In, Daewon Kim, Hyukmin Lee, Dongeun Yong, Kyoungwon Lee
Summary: This study evaluated the performance of MALDI-TOF MS in identifying nontuberculous mycobacteria (NTM) and achieved improved identification results through an upgraded database. The study laid the foundation for further application of MALDI-TOF MS in the rapid identification of NTM.
ANNALS OF LABORATORY MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jayeon Song, Baekdong Cha, Jeong Moon, Hyowon Jang, Sunjoo Kim, Jieun Jang, Dongeun Yong, Hyung-Jun Kwon, In-Chul Lee, Eun-Kyung Lim, Juyeon Jung, Hyun Gyu Park, Taejoon Kang
Summary: A DAMPR assay for the detection of SARS-CoV-2 and its variants genes with high accuracy and sensitivity is reported. A portable detection system and a smartphone application were developed to examine the diagnostic results. This method is of great significance for the rapid and accurate detection of SARS-CoV-2 and its variants genes, as well as the diagnosis of various infectious diseases.
Article
Chemistry, Multidisciplinary
Kyung Ho Kim, Sung Eun Seo, Chul Soon Park, Soomin Kim, Soohyun Lee, Choong-Min Ryu, Dongeun Yong, Yoo Min Park, Oh Seok Kwon
Summary: This study demonstrated the fabrication of a highly stable and efficient nanobiosensor using OICs as linkers on graphene. OPE was shown to have higher binding energy and lower band gap compared to other OICs, and it improved the immobilization efficiency of bioprobes by forming a self-assembly monolayer. The MOGMFET constructed using this technology exhibited high sensitivity, high selectivity, and a low detection limit.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Byunghoon Kang, Youngjin Lee, Jaewoo Lim, Dongeun Yong, Young Ki Choi, Sun Woo Yoon, Seungbeom Seo, Soojin Jang, Seong Uk Son, Taejoon Kang, Juyeon Jung, Kyu-Sun Lee, Myung Hee Kim, Eun-Kyung Lim
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a global pandemic of coronavirus disease (COVID-19). Early diagnosis, isolation, and prevention are crucial due to the lack of specific antiviral drugs and the emergence of viral variants. Researchers have developed a new fluorescence detection method that can accurately detect SARS-CoV-2 in a short period of time with a low detection limit.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Infectious Diseases
Ha-Young Choi, Bo-Min Kim, Young-Rok Kim, Taehui Yang, Sunjoo Ahn, Dongeun Yong, Jin-Hwan Kwak, Won-Gon Kim
Summary: The study demonstrates that coralmycin A exhibits potent antibacterial activity against clinical resistant bacteria and shows promising efficacy in animal models, indicating its potential as a new class of antibiotic for treating multidrug-resistant Gram-positive bacterial infections.
Article
Nanoscience & Nanotechnology
Mengdan Lu, Younju Joung, Chang Su Jeon, Sunjoo Kim, Dongeun Yong, Hyowon Jang, Sung Hyun Pyun, Taejoon Kang, Jaebum Choo
Summary: This study developed a dual-mode SERS-LFA strip that can accurately diagnose both SARS-CoV-2 and influenza A virus, reducing the false-negative rate significantly.
Article
Public, Environmental & Occupational Health
E. H. Lee, S. K. Lee, J. H. Cheon, H. Koh, J. A. Lee, C. H. Kim, J. N. Kim, K. H. Lee, S. J. Lee, J. H. Kim, J. Y. Ahn, S. J. Jeong, N. S. Ku, D. E. Yong, S. S. Yoon, J. S. Yeom, J. Y. Choi
Summary: This study aimed to compare the efficacy of different FMT methods for decolonizing MDRO and found that the oral capsule is an effective method. Discontinuation of antibiotics after FMT is a key factor in the success of decolonization.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Multidisciplinary Sciences
Yong Chan Kim, Heun Choi, Young Ah Kim, Yoon Soo Park, Young Hee Seo, Hyukmin Lee, Kyungwon Lee
Summary: Understanding the risk factors and microbiological features in recurrent E. coli BSI can aid clinicians in their management planning. Data from 2017 to 2018 were collected to assess antimicrobial resistance rates and molecular epidemiology. Risk factors for recurrence included vascular catheterization, ESBL phenotype, and high SOFA score. The highest proportion of ST131 and ESBL genotype was observed in early onset recurrent BSI. Whole genome sequencing revealed the presence of various virulence factors, resistant genes, and plasmid types in all types of BSI. This knowledge is important for clinicians in managing recurrent E. coli BSI.
Article
Multidisciplinary Sciences
Dongeun Yong, Hakbae Lee, Hyung-Gyu Min, Kyungnam Kim, Hyun-Seok Oh, Min Kyung Chu
Summary: This study investigated whether the composition of gut microbiota differed in participants with episodic migraine (EM) and chronic migraine (CM) compared to controls. The results showed significant differences in microbiota composition between the EM and CM groups and the control group. Moreover, a higher abundance of PAC000195_g was associated with lower headache frequency, while Agathobacter showed a significant negative association with severe headache intensity.
SCIENTIFIC REPORTS
(2023)
Article
Medical Laboratory Technology
Yangsoon Lee, Hye Gyung Bae, Dongju Won, Woobin Yun, Hyukmin Lee, Jong Rak Choi, Young Uh, Kyungwon Lee
Summary: In this study, the distribution of GBS isolates in pregnant Korean women was investigated. CC1 was the dominant lineage, followed by CC19, CC12, and CC17. The low prevalence of CC17 GBS colonization may explain the low frequency of neonatal GBS infections. Whole-genome sequencing is a useful tool for predicting antimicrobial susceptibility and capsular serotypes in GBS isolates.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Jong -Min Park, Mijung Kwon, Ki Ho Hong, Hyukmin Lee, Dongeun Yong
Summary: RAST is effective for early diagnosis and treatment of bloodstream infections caused by Klebsiella pneumoniae and Staphylococcus aureus, but not as accurate for Escherichia coli.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Immunology
Han Sang Kim, Chang Gon Kim, Won Kyu Kim, Kyung-A Kim, Jinseon Yoo, Byung Soh Min, Soonmyung Paik, Sang Joon Shin, Hyukmin Lee, Kyungwon Lee, Hoguen Kim, Eui-Cheol Shin, Tae-Min Kim, Joong Bae Ahn
Summary: This study found that Fusobacterium nucleatum (FN) in colorectal cancer tissues is associated with immune regulation in the tumor microenvironment, and its infection is correlated with poor prognosis and altered distribution of immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Mi Hyun Bae, Min -Sun Kim, Taek Soo Kim, Sunjoo Kim, Dongeun Yong, Gyoung Yim Ha, Nam Hee Ryoo, Young Uh, Jong Hee Shin, Hye Soo Lee, Yong-Hak Sohn, Sue Shin, Mi-Na Kim
Summary: The distribution and antimicrobial susceptibility of pathogenic bacteria in Korea have changed significantly over the past 20 years. Staphylococcus aureus prevalence initially increased and then decreased, while Escherichia coli became the most common species with an increase in cefotaxime resistance. Pseudomonas aeruginosa and Acinetobacter baumannii also increased in prevalence, along with imipenem resistance. Streptococcus agalactiae became the most common streptococcal species, and pneumococcal penicillin and levofloxacin susceptibility decreased.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medical Laboratory Technology
Gyu Ri Kim, Eun-Young Kim, Si Hyun Kim, Hae Kyung Lee, Jaehyeon Lee, Jong Hee Shin, Young Ree Kim, Sae Am Song, Joseph Jeong, Young Uh, Yu Kyung Kim, Dongeun Yong, Hyun Soo Kim, Sunjoo Kim, Young Ah Kim, Kyeong Seob Shin, Seok Hoon Jeong, Namhee Ryoo, Jeong Hwan Shin
Summary: After the introduction of PCV13 in Korea, there have been changes in the serotype distribution and antimicrobial resistance of invasive S. pneumoniae causing IPD. Non-PCV13 serotypes are increasing, and there are differences in antimicrobial resistance according to specific serotypes. Continuous monitoring of serotypes and antimicrobial resistance is crucial for the appropriate management of S. pneumoniae infections.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Shin Young Yun, Yunhee Lee, Juwon Hong, Dong-Chan Kim, Hyukmin Lee, Dongeun Yong, Yun Kyong Lim, Joong-Ki Kook, Kyungwon Lee
Summary: The aim of this study was to improve the accuracy and efficacy of identifying Fusobacterium species in clinical laboratories. Through the identification of 229 Fusobacterium isolates, the updated ASTA MicroIDSys system was found to be able to effectively identify nine species of Fusobacterium and four subspecies of F. nucleatum.
YONSEI MEDICAL JOURNAL
(2022)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
