Article
Infectious Diseases
Aya A. Mahfouz, Heba S. Said, Sherin M. Elfeky, Mona I. Shaaban
Summary: The increasing prevalence of erythromycin and erythromycin-induced clindamycin resistance in Staphylococcus aureus infection is a serious concern. This study identified the prevalence of resistance phenotypes and corresponding genes, and evaluated potential inhibitors. Several compounds were found to reduce erythromycin resistance and combat inducible clindamycin resistance. The findings emphasize the importance of managing antibiotic resistance and provide potential inhibitors for further investigation.
Article
Infectious Diseases
Sarita Manandhar, Raju Shrestha, Ratna Shova Tuladhar, Sunil Lekhak
Summary: This study aimed to investigate the incidence of MLSB resistance and biofilm formation in staphylococci. The findings showed a predominance of resistant phenotypes, especially among MRSA, highlighting the importance of routine D tests in the lab.
INFECTIOUS DISEASE REPORTS
(2021)
Article
Infectious Diseases
Hak Jin Lee, Seong Tae Jhang, Hyung Jong Jin
Summary: Resistance to Macrolide-lincosamide-streptogramin B antibiotics is mainly caused by the action of erythromycin ribosome methylation proteins. Research on the conservation region of Erms may lead to the development of inhibitors. The size and chemical properties of side chains in mutants significantly affect their activity.
Article
Medicine, Research & Experimental
Lutfun Nahar, Hideharu Hagiya, Takahiro Nada, Koji Iio, Kazuyoshi Gotoh, Osamu Matsushita, Fumio Otsuka
Summary: This study investigated the frequency and genotypic profiles of inducible resistance to macrolide, lincosamide, and streptogramin B (iMLSB) antibiotics in clindamycin-susceptible Staphylococcus aureus isolates. The results showed that approximately 33% of the isolates exhibited iMLSB resistance, predominantly caused by the ermA gene.
ACTA MEDICA OKAYAMA
(2023)
Article
Plant Sciences
Kuohai Yu, Lingling Wei, Hongjun Yuan, Weiqin Zhang, Xingquan Zeng, Bin Wang, Yulin Wang
Summary: This study performed genome-wide association studies (GWAS) and targeted metabolic profiling on 246 qingke varieties to evaluate drought sensitivity. The root-specific expressed gene CYP84 and various metabolites, including GABA, proline, sucrose, and raffinose, were found to be involved in the regulation of drought resistance. The study provides new insights into the response mechanism of plant drought stress and drought resistance breeding.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Infectious Diseases
Duangdaow Khunbutsri, Nattakarn Naimon, Khomson Satchasataporn, Natnaree Inthong, Sarawan Kaewmongkol, Samak Sutjarit, Chanokchon Setthawongsin, Nattakan Meekhanon
Summary: This study aimed to investigate the potential antibacterial activity of Solanum torvum leaf extract against multidrug-resistant Staphylococcus isolated from clinically healthy dogs. The results showed that the leaf extract displayed inhibitory effects, especially when used in combination with oxacillin.
Article
Infectious Diseases
Degi Janos, Herman Viorel, Iancu Ionica, Pascu Corina, Florea Tiana, Dascalu Roxana
Summary: The study investigated the prevalence of Staphylococcus species in dogs from an animal shelter in Timisoara, identifying various Staphylococcus isolates and detecting multidrug-resistant strains. This highlights a potential threat to both animal and human health, emphasizing the importance of monitoring and managing antibiotic resistance in veterinary and public health practices.
Review
Veterinary Sciences
Remous Ocloo, Justin Nyasinga, Zubair Munshi, Aisha Hamdy, Tessa Marciniak, Manonmani Soundararajan, Mae Newton-Foot, Wilma Ziebuhr, Adebayo Shittu, Gunturu Revathi, Alaa Abouelfetouh, Andrew Whitelaw
Summary: This systematic review provides a comprehensive overview of the epidemiology and antimicrobial resistance of non-Staphylococcus aureus Staphylococci (SOSA) in companion animals and livestock in Africa. The study highlights the lack of research on livestock-associated SOSA in certain regions of Africa and advocates for further studies on companion animals and the development of advanced methods for identification and strain typing of SOSA.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Janos Degi, Viorel Herman, Violeta Igna, Diana Maria Degi, Anca Hulea, Florin Muselin, Romeo Teodor Cristina
Summary: Treatment of staphylococcal infection in dogs is often associated with challenges such as side effects and drug resistance. This study evaluated the antimicrobial activity of Romanian propolis ethanolic extracts against Staphylococcus aureus strains in dogs. The results showed that the extracts had a pronounced antibacterial activity and could be a promising therapeutic agent for Staphylococcus aureus infections in dogs.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
A. Schnitt, T. Lienen, H. Wichmann-Schauer, B-A Tenhagen
Summary: This study found the occurrence of MR-NAS on dairy farms in Germany, with varying positive rates among different types of samples and in the environment. Nine species of MR-NAS were identified. Similar mobile genetic elements were detected in MR-NAS and MRSA on some farms, suggesting potential transfer of resistance genes between NAS and Staph. aureus on these farms.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
A. Rodriguez Jimenez, E. Dechamps, A. Giaux, L. Goetghebuer, M. Bauwens, P. Willenz, S. Flahaut, M. S. Laport, I. F. George
Summary: Cultivable bacteria associated with the marine sponges Hymeniacidon perlevis and Halichondria panicea exhibit promising antibacterial activity against multi-drug-resistant Staphylococcus aureus, indicating their potential as a valuable source of antibacterial compounds with pharmaceutical interest. This study is the first to show the antibacterial potential of these bacteria against MDR bacteria, including vancomycin nonsusceptible and methicillin-resistant strains, highlighting the urgent need for new antibiotics.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Yu Jin Lee, Young Ju Lee
Summary: This study investigated the pathogenic potential of Coagulase-negative staphylococci (CoNS) isolated from bulk tank milk. The results showed that these bacteria exhibited a high prevalence of biofilm-forming ability and multidrug resistance. Therefore, developing a strong monitoring and sanitation program for dairy factories is crucial for ensuring hygienic milk production.
VETERINARY SCIENCES
(2022)
Article
Infectious Diseases
Natalia Carrillo Gaeta, Joao Eduardo Cavalcante Brito, Juliana Maria Nunes Batista, Beatriz Gagete Verissimo de Mello, Ricardo Augusto Dias, Marcos B. Heinemann
Summary: This study aimed to investigate the species and antimicrobial susceptibility of Staphylococci on bat skin. The results showed that 42.8% of bats in the Metropolitan Region of Sao Paulo, Brazil carried Staphylococcaceae, mainly young bats in the rural area during summer. The majority of the isolates exhibited antibiotic resistance, indicating the potential transmission of clinically relevant Staphylococcus aureus and antimicrobial-resistant bacteria by bats.
Article
Multidisciplinary Sciences
Pauline C. Goeller, Tabea Elsener, Dominic Lorge, Natasa Radulovic, Viona Bernardi, Annika Naumann, Nesrine Amri, Ekaterina Khatchatourova, Felipe Hernandes Coutinho, Martin J. Loessner, Elena Gomez-Sanz
Summary: The study reveals that staphylococcal phages have a predominant multi-species host range, facilitating horizontal gene transfer. Additionally, there is potential for antibiotic resistance gene transfer among phages sharing common hosts.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Beverly Egyir, Esther Dsani, Christian Owusu-Nyantakyi, Grebstad Rabbi Amuasi, Felicia Amoa Owusu, Emmanuel Allegye-Cudjoe, Kennedy Kwasi Addo
Summary: This study investigates the antimicrobial resistance patterns of staphylococci isolated from livestock and farm attendants in Northern Ghana. The majority of the isolates show resistance to penicillin, clindamycin, cefoxitin, tetracycline, and erythromycin, but high susceptibility to gentamicin, sulphamethoxazole/trimethoprim, and rifampicin. Multiple resistance genes were commonly found among the staphylococcal isolates. Genome sequencing reveals that most of the methicillin-resistant staphylococci (MRS) isolates from livestock carry the mecA1 gene and the sal(A) gene, which confer resistance to beta-lactams, lincosamides, and streptogramins.
Article
Emergency Medicine
Mustafa Onur Oztan, Aysegul Aksoy Gokmen, Fatma Demet Arslan, Ebru Cakir, Ali Sayan, Elif Abay, Selcuk Kaya, Gokhan Koyluoglu
PEDIATRIC EMERGENCY CARE
(2020)
Article
Infectious Diseases
Huseyin Can, Aysegul Aksoy Gokmen, Mert Doskaya, Sedef Erkunt Alak, Aysu Degirmenci Doskaya, Muhammet Karakavuk, Ahmet Efe Koseoglu, Tugba Karakavuk, Ceren Gul, Mervenur Guvendi, Aytul Gul, Adnan Yuksel Guruz, Selcuk Kaya, Aurelien Mercier, Cemal Un
Summary: By sequencing and ELISA experiments, this study successfully proposed a serotyping schema that can be used to serotype T. gondii infections caused by type II, III, and Africa 1 genotypes.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Tuba Muderris, Bilal Olcay Peker, Nurten Gulvardar Baran, Aysegul Aksoy Gokmen, Selcuk Kaya, Sureyya Gul Yurtsever
Summary: Syphilis and HIV have a strong association and co-infection is common in HIV-positive individuals. This study aimed to determine the seroprevalence of syphilis in HIV-positive patients and found that a significant proportion of patients were positive for both syphilis and HIV-RNA. Routine screening for other sexually transmitted diseases is crucial in the presence of STDs. The findings provide important insights into future research on the prevention and eradication of HIV/syphilis infections.
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
(2022)
Article
Parasitology
Tuelay Oncue Oner, Mehmet Karabey, Huseyin Can, Aysu Degirmenci Doskaya, Muhammet Karakavuk, Aytuel Gul, Ahmet Efe Koseoglu, Mert Doskaya, Cemal Un, Adnan Yuksel Guruz, Selcuk Kaya, Bayram Pektas, Ayseguel Aksoy Gokmen
Summary: This study investigated the prevalence of Blastocystis sp. and its subtypes in patients with different types of malignant solid tumors undergoing chemotherapy. The results showed a molecular prevalence of 48.9% for Blastocystis, with ST4 being the most predominant subtype.
Article
Oncology
Ayse Akbiyik, Huseyin Tasli, Nermin Topaloglu, Vildan Alptuzun, Sulunay Parlar, Selcuk Kaya
Summary: Antimicrobial photodynamic inactivation (aPDI) of multidrug-resistant wound pathogens was evaluated using cationic porphyrin derivatives (CPDs). The study showed that aPDI with CPD PL exhibited the best antimicrobial effect without significant cytotoxicity.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Microbiology
Tuba Muderris, Tugce Albayrak, Efecan Erisken, Ayse Karatas Demirciler, Hamit Gunes Feran, Selcuk Kaya
Summary: This case report presents a meningitis case caused by Abiotrophia defectiva in a patient who had undergone neurosurgery, and reviews all cases of central nervous system infections caused by NVS in the literature. This is the first reported case of A. defectiva meningitis in our country, according to the available literature.
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
(2022)
Article
Medicine, General & Internal
Serkan Bilgin, Adnan Yamanoglu, Ahmet Kayali, Umut Payza, Mehmet Goktug Efgan, Osman Sezer Cinaroglu, Selcuk Kaya
Summary: The purpose of this study is to describe long COVID-19 symptoms in patients receiving outpatient treatment. A 12-week follow-up of COVID-19 outpatients revealed that 23% of patients experienced at least one long COVID symptom. The frequency of symptoms varied with gender, age, and blood type, with myalgia being the most common symptom.
CUKUROVA MEDICAL JOURNAL
(2023)
Article
Infectious Diseases
Merve Zerey Albayrak, Sureyya Gul Yurtsever, Bilal Olcay Peker, Tuba Muderris, Selcuk Kaya
Summary: This study evaluated the antibody and T cell responses of homologous and heterologous booster doses for SARS-CoV-2 vaccines. The results showed that individuals who received heterologous boosters had higher antibody levels and higher levels of IFN-gamma, IL-2, and IL-13.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2024)
Article
Microbiology
Ufuk Akbayirli, Selcuk Kaya, Aysegul Aksoy Gokmen
Summary: COVID-19 patients have higher levels of PTX3 and suPAR, and low levels of PTX3 and suPAR may be clinically important.
MIKROBIYOLOJI BULTENI
(2022)
Article
Infectious Diseases
Yesim Tuyji-Tok, Asli Gamze Sener, Ayseguel Aksoy-Gokmen, Tuna Demirdal, Selcuk Kaya
Summary: This study indicates that the percentage of Tregs in patients with hepatitis C infection is significantly higher than in healthy controls, and is strongly correlated with HCV RNA load and serum AFP levels. Tregs are believed to play a crucial role in the immunology of HCV infection, providing a promising method for predicting disease prognosis and new treatments.
INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Mehmet Karabey, Huseyin Can, Tulay Oncu Oner, Mert Doskaya, Sedef Erkunt Alak, Aysu Degirmenci Doskaya, Muhammet Karakavuk, Ahmet Efe Koseoglu, Cemal Un, Adnan Yuksel Guruz, Ahmet Alacacioglu, Bayram Pektas, Aytul Gul, Selcuk Kaya, Aysegul Aksoy Gokmen
Summary: This study investigated the prevalence of Cryptosporidium spp. among patients undergoing chemotherapy for malignant solid tumors, revealing a certain percentage of patients infected with the parasite. The findings suggest the importance of using at least two different diagnostic methods to diagnose Cryptosporidium infection accurately.
ANNALS OF SAUDI MEDICINE
(2021)
Article
Medicine, General & Internal
Sureyya Gul Yurtsever, Selcuk Kaya, Tamer Arkali, Tuba Muderris, Pelin Gunaydin, Yuksel Kucuzeybek
Article
Microbiology
Yesim Tuyji Tok, Asli Gamze Sener, Aysegul Aksoy Gokmen, Tuna Demirdal, Selcuk Kaya
MIKROBIYOLOJI BULTENI
(2020)
Article
Medicine, General & Internal
Sureyya Gul Yurtsever, Abdurrahman Aygul, Ismail Ozturk, Salih Atakan Nemli, Selcuk Kaya, Safak Ermertcan
EUROPEAN JOURNAL OF THERAPEUTICS
(2020)
Article
Medicine, General & Internal
Isa Dongel, Aysegul Aksoy Gokmen, Hasan Ekrem Camas, Ibak Gonen, Selcuk Kaya
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2020)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
