Review
Peripheral Vascular Disease
Carlos Escudero, Ellen Kupka, Belen Ibanez, Hermes Sandoval, Felipe Troncoso, Anna-Karin Wikstroem, Daniela Lopez-Espindola, Jesenia Acurio, Pablo Torres-Vergara, Lina Bergman
Summary: Preeclampsia is a maternal syndrome characterized by hypertension and proteinuria after 20 weeks of gestation with brain complications being the main cause of morbidity and mortality, especially in low- and middle-income countries. In addition to the cardiovascular effects, women with preeclampsia have higher risk of stroke, dementia, white matter lesions, epilepsy, and cognitive decline postpartum, and evidence also links preeclampsia with similar cognitive and cerebral disorders in offspring. However, the mechanistic links between these associations remain unresolved. This article summarizes the current knowledge and potential pathophysiological mechanisms of cerebrovascular complications in preeclampsia.
Article
Multidisciplinary Sciences
Issam Rimawi, Sunny Yanai, Gadi Turgeman, Joseph Yanai
Summary: This study investigated the effects of paternal exposure to chlorpyrifos, a developmental insult, on the offspring's gene expression using an avian model. The results showed significant changes in mRNA gene expression in the offspring, particularly in genes related to neurogenesis, learning, and memory. The effects of paternal exposure were more pronounced in female offspring.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Francesca Castiello, Beatriz Suarez, Andrea Beneito, Maria-Jose Lopez-Espinosa, Loreto Santa-Marina, Aitana Lertxundi, Adonina Tardon, Isolina Riano-Galan, Maribel Casas, Martine Vrijheid, Nicolas Olea, Mariana F. Fernandez, Carmen Freire
Summary: This study examined the associations between urinary metabolites of non-persistent pesticides and pubertal development in children from urban and rural areas in Spain. The results showed that higher concentrations of certain pesticide metabolites were associated with increased odds of pubertal development, especially in girls, and BMI may modify these associations.
ENVIRONMENTAL POLLUTION
(2023)
Article
Rheumatology
John A. Reynolds, Mary Gayed, Munther A. Khamashta, Francesca Leone, Veronica Toescu, Ian N. Bruce, Ian Giles, Lee-Suan Teh, Neil McHugh, Mohammed Akil, Christopher J. Edwards, Caroline Gordon
Summary: This study investigated the outcomes of children born to mothers with SLE exposed to HCQ or AZA during pregnancy. The results showed that there were no significant negative outcomes in children exposed to HCQ during pregnancy. However, the use of AZA was associated with an increased reporting of childhood infection, which requires further study.
Article
Obstetrics & Gynecology
Ashild Jensen Kolseth, Signe Kulseth, Signe Nilssen Stafne, Siv Morkved, Kjell asmund Salvesen, Kari Anne I. Evensen
Summary: This study aimed to investigate the impact of gestational diabetes risk factors on the physical health and neurodevelopment of children at 7 years of age. The children born to mothers with a risk of gestational diabetes had higher birthweight and length and were more likely to be overweight at the age of 7. However, there was no difference in physical activity levels and neurodevelopmental outcomes between the two groups. The prevention of pre-pregnancy overweight should be emphasized.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Women's Studies
Shani Pitcho-Prelorentzos, Elazar Leshem, Michal Mahat-Shamir
Summary: This qualitative study explores the narrative identities of women bereaved to intimate partner femicide. Through interviews with 11 Israeli female participants whose biological mothers were murdered by their biological fathers, the study finds that they experience unique challenges in identity reconstruction as they are neither like their fathers nor their mothers, and society may also have biased perceptions about them.
VIOLENCE AGAINST WOMEN
(2023)
Article
Gastroenterology & Hepatology
Helene Chiarella-Redfern, Sangmin Lee, Bellal Jubran, Nastaran Sharifi, Remo Panaccione, Cora Constantinescu, Eric Benchimol, Cynthia H. Seow
Summary: Pregnant women with IBD were investigated for vaccination rates and factors influencing vaccine administration. Vaccination rates were relatively good in pregnant women with IBD, but improvements are needed. Inadvertent administration of the rotavirus vaccine in biologic-exposed infants did not result in significantly more adverse events.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Endocrinology & Metabolism
Anuradhaa Subramanian, Jan Idkowiak, Konstantinos A. Toulis, Shakila Thangaratinam, Wiebke Arlt, Krishnarajah Nirantharakumar
Summary: The studies on the pubertal timing of boys and girls born to mothers with gestational diabetes mellitus (GDM) suggest a potential influence of maternal GDM on the timing of puberty, although the current evidence is scarce and of limited quality. Further prospective cohort studies coupled with objective biochemical tests are needed to provide more insights into this relationship.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Nursing
Amber C. Welborn, Tracy Nichols, Meredith Gringle, Lynne Lewallen
Summary: This study explores the impact of power dynamics and hospital organizational structure on neonatal intensive care nurses' experiences in caring for infants and families affected by substance exposure during pregnancy. The study findings suggest that nurses face challenges due to high workloads, power imbalances, and organizational constraints, which hinder the provision of high-quality, family-centered care. Workload issues may contribute to stigma and inhibit relationship-building opportunities between nurses and families.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Pediatrics
Christiana Smith, Lori Silveira, Megan Crotteau, Krystle Garth, Jennifer Canniff, Kirk B. Fetters, Sarah Lazarus, Shannon Capraro, Adriana Weinberg, CHIP Perinatal Team
Summary: In sub-Saharan Africa, tuberculosis is a major public health issue and is often associated with HIV co-infection. Establishing TB diagnostics among HIV-infected individuals is critical for timely management and control of tuberculosis transmission.
FRONTIERS IN PEDIATRICS
(2022)
Article
Environmental Sciences
Kerstin Kraetschmer, Rainer Malisch, Walter Vetter
Summary: The study analyzed levels of chlorinated paraffins in human milk samples from 53 countries, with CPs detected in all samples at concentrations of 23-700 ng/g lipid, accounting for 18-46% of total POPs. CP concentrations exceeded PCB concentrations in most countries, emphasizing the need for regulation and research on health effects related to CPs.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Hematology
Marc Righini, Helia Robert-Ebadi, Alessio Cremonesi, Antoine Elias, Olivier Sanchez, Emmanuelle Le Moigne, Jeannot Schmidt, Catherine Le Gall, Jacques Cornuz, Drahomir Aujesky, Pierre-Marie Roy, Celine Chauleur, Frederic Rouyer, Pierre-Alexandre Poletti, Caroline Moreau, Gregoire Le Gal
Summary: No cases of neonatal hypothyroidism were identified among 149 pregnant women investigated for suspected pulmonary embolism using CTPA, providing further reassurance regarding the safety of CTPA in this indication.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Immunology
Shari Sapuan, Nick Andrews, Bassam Hallis, Laura Hole, Christine E. Jones, Mary Matheson, Elizabeth Miller, Matthew D. Snape, Paul T. Heath
Summary: The study evaluated the long-term impact of antenatal pertussis vaccination on children's immune response and found that the blunting effect on pertussis responses can persist until preschool age but is overcome by a preschool booster dose.
Article
Psychology, Developmental
Farah Ghosn, Pablo Navalon, Laura Pina-Camacho, Belen Almansa, Rosa Sahuquillo-Leal, Alba Moreno-Gimenez, Vicente Diago, Maximo Vento, Ana Garcia-Blanco
Summary: Infants born after a threatened preterm labour (TPL infants) are at high risk of autism spectrum disorder (ASD). This study found that TPL infants showed higher autistic symptom load at age 30 months, with poorer communication and problem-solving skills, and greater vocal reactivity. Higher levels of anxiety symptoms in TPL mothers after a TPL diagnosis also predicted higher autistic symptom load for the infants at age 30 months.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Psychology, Developmental
Vered Ben-David, Guy Enosh
Summary: The study analyzes the Israeli legal discourse surrounding motherhood, parenting capacity, and marginalized women whose parental rights were terminated, finding associations between maternal unfitness and sexual immorality, illegitimacy, and inappropriate sexual choices. Discussions focus on the importance of women's voices in parenting decision-making processes, and the need for professionals to avoid bias against socially marginalized women and critically reflect on why information about a mother's sexual conduct is relevant to the assessment of parental fitness and the child's best interest.
Article
Psychology, Developmental
Camilla V. B. Palm, Dorte Glintborg, Laura G. Find, Pia Larsen, Cilia M. Dalgaard, Henriette Boye, Tina K. Jensen, Anja F. Dreyer, Marianne S. Andersen, Niels Bilenberg
Summary: Maternal testosterone levels were positively associated with ASD traits in boys, while maternal PCOS was associated with increased ASD traits in offspring. However, the association became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychiatry
Emily Cantio, Niels Bilenberg, Signe Monrad Norgaard, Iben Have Beck, Soren Moller, Cathriona Cantio, Tina Kold Jensen, Nicoline Bebe Mortensen, Asta Rasmussen, Henrik Boye Thybo Christesen
Summary: This study investigates the association between blood concentrations of serum 25-hydroxyvitamin D at different time points and intelligence quotient score at the age of 7, and explores potential differences in the association based on child sex.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Ophthalmology
Diana C. Schmidt, Line Kessel, Daniella Bach-Holm, Katharina M. Main, Dorte A. Larsen, Regitze Bangsgaard
Summary: This study aimed to investigate the prevalence and risk factors of hypothalamus-pituitary-adrenal axis suppression in infants receiving glucocorticoid eye drops. The results showed that high daily glucocorticoid doses per weight were associated with HPA axis suppression in infants. Monitoring is necessary for infants receiving glucocorticoids after ocular surgery.
ACTA OPHTHALMOLOGICA
(2023)
Article
Environmental Sciences
Marie Tysman, Jorma Toppari, Katharina M. Main, Annika Adamsson, Christine Wohlfahrt-Veje, Jean-Philippe Antignac, Bruno Le Bizec, Eliisa Loyttyniemi, Niels E. Skakkebaek, Helena E. Virtanen
Summary: Hypospadias is a congenital malformation of the penile urethra, and the etiology is mostly unknown. This study investigated the association between hypospadias and exposure to persistent organic pollutants (POPs) through breast milk. The study included Danish and Finnish mother-son pairs, and breast milk samples were analyzed for various classes of POPs. The results did not show any significant associations between POP concentrations and hypospadias in either country. This study provides information on quantitative exposures but does not support a direct link between hypospadias and POP exposure.
Article
Public, Environmental & Occupational Health
Antje Gerofke, Madlen David, Phillipp Schmidt, Joana Lobo Vicente, Jurgen Buekers, Liese Gilles, Ann Colles, Jos Bessems, Michiel Bastiaensen, Adrian Covaci, Elly Den Hond, Gudrun Koppen, Michelle Laeremans, Veerle J. Verheyen, Milena Cerna, Jana Klanova, Andrea Krskova, Martin Zvonar, Lisbeth E. Knudsen, Holger M. Koch, Tina Kold Jensen, Loic Rambaud, Margaux Riou, Nina Vogel, Catherine Gabriel, Spyros Karakitsios, Nafsika Papaioannou, Denis Sarigiannis, Reka Kakucs, Szilvia Kozepesy, Peter Rudnai, Tamas Szigeti, Fabio Barbone, Valentina Rosolen, Cedric Guignard, Arno C. Gutleb, Amrit Kaur Sakhi, Line Smastuen Haug, Beata Janasik, Danuta Ligocka, Milada Estokova, Lucia Fabelova, Branislav Kolena, Lubica Palkovicova Murinova, Ida Petrovicova, Denisa Richterova, Milena Horvat, Darja Mazej, Janja Snoj Tratnik, Agneta Annika Runkel, Argelia Castano, Marta Esteban-Lopez, Susana Pedraza-Diaz, Agneta Akesson, Sanna Lignell, Jelle Vlaanderen, Jan-Paul Zock, Greet Schoeters, Marike Kolossa-Gehring
Summary: Within the HBM4EU initiative, HBM indicators were developed to address key policy questions and support chemical policies. Result indicators provide information on chemical exposure in different demographic groups and allow comparisons to identify differences and inform policy measures. Impact indicators assess health risks by comparing exposure values to health-based guidance values, helping to identify relevant health issues and support risk management decisions.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Andrology
Laura Smidt Hansen, Laerke Priskorn, Stine A. Holmboe, Tina Kold Jensen, Ann Holm Hansen, Anna-Maria Andersson, Niels Jorgensen
Summary: This study found an association between testicular function and markers of metabolic and cardiovascular health in young men. Reproductive hormone levels and semen quality may serve as early biomarkers of cardiovascular health in healthy men.
Review
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Trine Holm Johannsen, Margit Bistrup Fischer, Emmie N. Upners, Alexander S. Busch, Katharina M. Main, Anna-Maria Andersson, Casper P. Hagen, Anders Juul
Summary: The ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been found to be a reliable marker for sex determination in healthy infants. However, its role in patients with differences of sex development (DSD) remains unclear. This retrospective study aimed to describe LH/FSH in infants with DSD and found that the ratio sometimes corresponds to the assigned sex, but not in all cases.
ENDOCRINE CONNECTIONS
(2023)
Article
Biology
Marc K. Pedersen, Elvira V. Brauner, Ann H. Hansen, Laura S. Hansen, Tina K. Jensen, Niels Jorgensen, Laerke Priskorn
Summary: In this cross-sectional study, the association between self-reported asthma and testicular function was investigated. The results showed that men with self-reported asthma had poorer testicular function, specifically lower total sperm count and borderline lower sperm concentration compared to men without asthma. However, the causality cannot be determined due to the study's design limitations.
Article
Environmental Sciences
Damaskini Valvi, David C. Christiani, Brent Coull, Kurt Hojlund, Flemming Nielsen, Karine Audouze, Li Su, Pal Weihe, Philippe Grandjean
Summary: This study evaluated the genetic heterogeneity as a modifier in the association between perfluoroalkyl substances (PFAS) and insulin sensitivity and pancreatic beta-cell function. The findings suggest that certain genetic variations play an important role in the association between PFAS and insulin sensitivity.
ENVIRONMENTAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Philippe Grandjean, Alessandra Meddis, Flemming Nielsen, Anders Sjodin, Mads F. F. Hjorth, Arne Astrup, Esben Budtz-Jorgensen
Summary: The objective of this study was to test the association between perfluorinated alkylate substance (PFAS) exposures and body weight increases in a dietary intervention study. The results showed that elevated plasma concentrations of PFOA and PFHxS were significantly associated with increased weight gain, exceeding the effects of different diet groups. The findings suggest that obesogenic PFASs may contribute to the obesity pandemic.
Article
Pediatrics
Philippe Grandjean, Yu-Hsuan Shih, Louise Helskov Jorgensen, Flemming Nielsen, Pal Weihe, Esben Budtz-Jorgensen
Summary: A study found that early exposure to perfluoroalkyl substances (PFASs) was associated with lower resistin concentrations at the age of 9, suggesting that infancy may be a vulnerable time window for metabolic programming affected by PFAS exposure.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Nutrition & Dietetics
Kamil Demircan, Richard Christian Jensen, Thilo Samson Chillon, Tina Kold Jensen, Qian Sun, Steen Joop Bonnema, Julian Hackler, Tim I. M. Korevaar, Dorte Glintborg, Lutz Schomburg, Marianne Skovsager Andersen
Summary: This study found that low serum selenium levels during pregnancy, particularly low selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPX3) activity, were associated with an increased risk of gestational diabetes mellitus (GDM) and large for gestational-age offspring. Offering selenium status assessment during pregnancy can identify high-risk women for GDM who may benefit from selenium substitution.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Obstetrics & Gynecology
Camilla V. B. Palm, Anja F. Dreyer, Henriette Boye, Jan S. Jorgensen, Chunsen Wu, Frederik D. Hojsager, Tina K. Jensen, Dorte Glintborg, Marianne S. Andersen
Summary: This study found associations between maternal testosterone levels and birth anthropometrics in offspring. Higher levels of maternal testosterone were linked to lower birth weight, length, and abdominal circumference in boys, but no associations were found in girls.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Environmental Sciences
Valentina Rosolen, Elisa Giordani, Marika Mariuz, Maria Parpinel, Vicente Mustieles, Liese Gilles, Eva Govarts, Laura Rodriguez Martin, Kirsten Baken, Greet Schoeters, Ovnair Sepai, Eva Sovcikova, Lucia Fabelova, Jiri Kohoutek, Tina Kold Jensen, Adrian Covaci, Maarten Roggeman, Lisa Melymuk, Jana Klanova, Argelia Castano, Marta Esteban Lopez, Fabio Barbone
Summary: The knowledge about the effects of organophosphate flame retardants on children's neurodevelopment is limited. This research aimed to evaluate the association between exposure to these flame retardants and children's neurodevelopment. The study found a small, negative trend between neurodevelopment and exposure to BDCIPP and DPHP, but the evidence is limited. Further investigations are needed to explore the timing of exposure and the effect of other metabolites.