期刊
INTERNATIONAL JOURNAL OF ANDROLOGY
卷 33, 期 2, 页码 252-258出版社
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2605.2009.01001.x
关键词
cell differentiation; disorders of sex differentiation; DSD; germ cells
类别
P>Testes and ovaries develop from the same primordial structures, the genital ridges, in the mammalian foetus. Male development depends critically on the correct functioning of the Y-linked testis-determining gene, Sry. However, Sry is highly vulnerable to mutation, and so does not provide a very robust sex-determining mechanism. Both in testes and in ovaries, proper gonadal development involves co-ordinated regulation of the bipotential fates of a number of different cell lineages, and is dependent on intercellular signalling mechanisms. If either the testicular or ovarian pathway stalls in the early stages, mechanisms operate to engage the alternative pathway. For these reasons, the early steps in mammalian sexual development are vulnerable to genetic and environmental perturbation, and represent possible points of action of endocrine disrupting compounds.
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