Article
Pediatrics
Lei Gao, Daxing Tang, Weizhong Gu
Summary: This study analyzed the histopathological features of resected testicular remnant specimens and found a very low incidence of SNTs and GCs, indicating extremely low chances of potential malignancy. It suggested that surgical removal of vanishing testis remnants may not be necessary.
FRONTIERS IN PEDIATRICS
(2022)
Article
Andrology
Carme Grande-Moreillo, Sara Fuentes-Carretero, Jaume Margarit-Mallol, Carlos Perez-Lopez, Alejandro Rodriguez-Molinero
Summary: Acquired cryptorchidism accounts for more than half of cryptorchidism cases requiring surgery in our setting, with a clearly different age of presentation than that for congenital cryptorchidism.
Article
Medicine, General & Internal
Jerzy Niedzielski, Maciej Nowak, Piotr Kucharski, Katarzyna Marchlewska, Jolanta Slowikowska-Hilczer
Summary: This study aimed to investigate the prevalence of testicular, epididymal, and vasal anomalies (TEVA) in pediatric patients with cryptorchidism and communicating hydrocele. The results showed that TEVA were more commonly found in boys with undescended testes and were associated with testis position and size.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jae Yeon Kim, Jae Min Chung
Summary: This study evaluated the practice patterns of Korean urologists regarding the diagnosis and management of retractile and gliding testes. The findings showed that more than half of the urologists found it difficult to distinguish between the two conditions in the clinical setting, leading to a higher tendency for surgical correction. Therefore, establishing practical guidelines is crucial in preventing unnecessary surgical treatment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Riccardo Bartoletti, Antonio Luigi Pastore, Filippo Menchini Fabris, Tommaso Di Vico, Riccardo Morganti, Andrea Mogorovich, Girolamo Morelli, Diego Peroni, Yazan Al Salhi, Alessandro Zucchi
Summary: This study aimed to investigate the best treatment to preserve fertility in cryptorchid subjects. The results showed that early prolonged hormonal therapy can improve sperm quality in adult patients, with the best outcome observed in patients treated with combined hormone and surgery therapy.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Pediatrics
Andrea Schmedding, Felix van Wasen, Ralf Lippert
Summary: An undescended testis is the most common genitourinary disease in boys. The study analyzed the implementation of German guidelines proposing orchidopexy before 12 months of age, 10 years after publication.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Surgery
J. A. O'Kelly, K. J. Breen, R. Amoateng, L. Scanlon, E. J. Redmond, E. A. Kiely
Summary: The study evaluated the referral patterns and diagnostic factors of undescended testis in boys. Most referrals were from primary care physicians, but a majority of boys referred for assessment did not have undescended testis. Predictive factors such as history of prematurity, mention of undescended testis at birth, and scrotal asymmetry were identified as aiding in the diagnosis of undescended testis.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Urology & Nephrology
Anthony D'Oro, Ilina Rosoklija, Elizabeth B. Yerkes, Bruce W. Lindgren, Karen Rychlik, Earl Y. Cheng
Summary: Patients with proximal hypospadias have an increased risk of acquired cryptorchidism, and operative notes reveal a high rate of epididymal nonfusion with ascended testes. Close monitoring of testis position is necessary for these patients.
JOURNAL OF UROLOGY
(2021)
Article
Surgery
J. A. O'kelly, K. J. Breen, R. Amoateng, L. Scanlon, E. J. Redmond, E. A. Kiely
Summary: This study aimed to assess referral patterns and identify predictive factors for undescended testis (UDT) that can assist primary care physicians in diagnosing the condition. The majority of referred boys were older than the recommended age for orchidopexy, and most of the assessed boys did not have UDT. Prematurity, parental awareness of UDT at birth, and scrotal asymmetry were identified as predictive factors for UDT.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Genetics & Heredity
Carmen Iulia Ciongradi, Ioan Sarbu, Codruta Olimpiada Iliescu Halitchi, Diana Benchia, Klara Sarbu
Summary: Cryptorchidism is a common diagnosis in pediatric urology, with ongoing debates about the optimal timing for surgery and expected results. This review aims to clarify the impact of cryptorchidism on testicular histology and function, semen analysis, the relationship between hormonal and surgical treatment, future fertility, and paternity rate.
Review
Pediatrics
Qiongzhang Xia, Tongshuai Kuang, Xiaokun Lin, Hua Zhang
Summary: This study analyzed the clinical records of a 1-year-old male with a testicular tumor originating in the intra-abdominal undescended testis. The patient underwent laparoscopic orchiopexy and tumor excision, and had a successful recovery. Literature review showed that mature teratomas are the most common type of intra-abdominal testicular tumors. Early diagnosis and prompt surgical intervention lead to excellent outcomes.
FRONTIERS IN PEDIATRICS
(2023)
Article
Reproductive Biology
N. Prapaiwan, S. Manee-in, R. Thanawongnuwech, S. Srisuwatanasagul
Summary: AMH analysis has provided new information in the reproductive endocrinology of domestic animals with clinically available diagnostic tools. This study evaluates the clinical relevance of AMH analysis in peripheral blood as a diagnostic tool for dogs with suspected bilateral abdominal cryptorchidism. The results suggest that AMH levels in peripheral blood can be used as an alternative and rapid screening method for detecting dogs with abdominal cryptorchidism.
Article
Pediatrics
Lars Dinkelbach, Dirk Lehnick, Sandra Shavit, Philipp Szavay, Sabine Zundel
Summary: Acquired undescended testes are a common cause of cryptorchidism, with ascent occurring between the ages of one and fourteen, emphasizing the need for regular follow-up of testicular position until puberty.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Wei Zhou, Shoulin Li, Hao Wang, Guanglun Zhou, Jianguo Wen
Summary: This study aimed to explore the value of ultrasound in the preoperative diagnosis of NPT in children. The results showed that ultrasound had a high consistency rate when compared with surgical exploration and pathological results, especially in identifying EAT and IAT with normal testicular morphology.
SCIENTIFIC REPORTS
(2022)
Review
Pediatrics
Gulcan Sarila, John M. Hutson, Jaya Vikraman
Summary: This article reviews the complex anatomical steps and hormonal regulation of testicular descent, highlighting many overlooked areas of morphology and signaling pathways in the search for causes of undescended testes (UDT).
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Ophthalmology
Diana C. Schmidt, Line Kessel, Daniella Bach-Holm, Katharina M. Main, Dorte A. Larsen, Regitze Bangsgaard
Summary: This study aimed to investigate the prevalence and risk factors of hypothalamus-pituitary-adrenal axis suppression in infants receiving glucocorticoid eye drops. The results showed that high daily glucocorticoid doses per weight were associated with HPA axis suppression in infants. Monitoring is necessary for infants receiving glucocorticoids after ocular surgery.
ACTA OPHTHALMOLOGICA
(2023)
Article
Environmental Sciences
Marie Tysman, Jorma Toppari, Katharina M. Main, Annika Adamsson, Christine Wohlfahrt-Veje, Jean-Philippe Antignac, Bruno Le Bizec, Eliisa Loyttyniemi, Niels E. Skakkebaek, Helena E. Virtanen
Summary: Hypospadias is a congenital malformation of the penile urethra, and the etiology is mostly unknown. This study investigated the association between hypospadias and exposure to persistent organic pollutants (POPs) through breast milk. The study included Danish and Finnish mother-son pairs, and breast milk samples were analyzed for various classes of POPs. The results did not show any significant associations between POP concentrations and hypospadias in either country. This study provides information on quantitative exposures but does not support a direct link between hypospadias and POP exposure.
Article
Clinical Neurology
Line Pickering, Katharina M. M. Main, Ulla Feldt-Rasmussen, Astrid Sehested, Rene Mathiasen, Marianne Klose, Rikke Ibsen, Jakob Kjellberg, Poul Jennum
Summary: This nationwide prospective cohort study in Denmark aimed to evaluate survival distributions, long-term socioeconomic consequences, and health care costs in patients with childhood and adolescent onset of brain tumours. The study found that the probability of mortality was highest during the first year after tumour diagnosis. In young adulthood, the patients had negative long-term socioeconomic consequences, such as lower educational levels, employment rates, and higher health care costs.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Environmental Sciences
Louise Scheutz Henriksen, Hanne Frederiksen, Niels Jorgensen, Anders Juul, Niels E. Skakkebaek, Jorma Toppari, Jorgen Holm Petersen, Katharina M. Main
Summary: This study aimed to explore if there is an association between fetal phthalate exposure and markers of testicular function in young adult men. The results showed that higher maternal phthalate exposure was associated with higher luteinizing hormone (LH) but unchanged testosterone in adult sons. Additionally, higher maternal exposure was associated with lower total and free testosterone/LH ratios in adult sons.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Trine Holm Johannsen, Margit Bistrup Fischer, Emmie N. Upners, Alexander S. Busch, Katharina M. Main, Anna-Maria Andersson, Casper P. Hagen, Anders Juul
Summary: The ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been found to be a reliable marker for sex determination in healthy infants. However, its role in patients with differences of sex development (DSD) remains unclear. This retrospective study aimed to describe LH/FSH in infants with DSD and found that the ratio sometimes corresponds to the assigned sex, but not in all cases.
ENDOCRINE CONNECTIONS
(2023)
Article
Medicine, General & Internal
Casper P. Hagen, Margit Bistrup Fischer, Christine Wohlfahrt-Veje, Maria Assens, Alexander S. Busch, Anette Tonnes Pedersen, Anders Juul, Katharina M. Main
Summary: This study indicates that ovarian activity in healthy girls remains remarkably stable from small growing follicles, suggesting that AMH concentrations in early life can serve as a useful clinical tool to predict future ovarian activity.
Article
Anesthesiology
Pernille D. K. Diasso, Dalia Abou-Kassem, Susanne D. Nielsen, Katharina M. Main, Per Sjogren, Geana P. Kurita
Summary: Long-term opioid treatment (L-TOT) for chronic non-cancer pain (CNCP) may result in endocrine dysfunction, including changes in testosterone, growth hormone, and prolactin levels. This study found that compared to CNCP patients not receiving opioids, those on L-TOT had lower testosterone and growth hormone levels, as well as higher prolactin levels. Additionally, a correlation was observed between high opioid dose and low growth hormone levels.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Endocrinology & Metabolism
Jakob Albrethsen, Peter Busch Ostergren, Pernille Badsberg Norup, Jens Sonksen, Mikkel Fode, Caroline Kistorp, Nikolai B. Nordsborg, Sara Amalie Solheim, Jakob Morkeberg, Katharina M. Main, Anders Juul
Summary: This study aimed to investigate the changes in serum insulin-like factor 3 (INSL3) concentration during hypothalamus-pituitary-testicular suppression. The results showed that INSL3 levels decreased during experimental testicular suppression and returned to baseline levels after release of suppression. Similarly, INSL3, testosterone, and LH concentrations decreased during therapeutic hormonal hypothalamus-pituitary-testicular suppression in transgender girls and patients with prostate cancer. Therefore, INSL3 can serve as a sensitive marker of testicular suppression and complement testosterone measurement in male reproductive disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hans Valdemar Lopez Krabbe, Jorgen Holm Petersen, Louise Laub Asserhoj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Laerke Priskorn, Niels Jorgensen, Katharina M. Main, Anders Juul, Lise Aksglaede
Summary: Adult patients with Klinefelter syndrome (KS) exhibit variable phenotypes and a high risk of metabolic disorders. Most adults require testosterone replacement therapy (TRT), but its use during puberty is debated. This study found that patients with KS have unfavorable body composition and impaired bone mineral status already during childhood and adolescence. Further research is needed to evaluate the effects of TRT during puberty on these parameters.
ENDOCRINE CONNECTIONS
(2023)
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Health Care Sciences & Services
Agnethe Berglund, Marie J. Ornstrup, Marie Lind-Holst, Morten Duno, Marie Baekvad-Hansen, Anders Juul, Luise Borch, Niels Jorgensen, Ase K. Rasmussen, Marianne Andersen, Katharina M. Main, Dorte Hansen, Claus H. Gravholt
Summary: This study aimed to describe diagnostic trends for all patients with CAH in Denmark. The prevalence of CAH combined was 15.1 and 9.0 per 100,000 newborn females and males, respectively. Diagnosis of NC-CAH increased significantly during the course of the study.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Endocrinology & Metabolism
And Demir, Matti Hero, Anders Juul, Katharina M. Main
Summary: The study aimed to investigate the association between central pubertal activation ages and clinical signs of puberty, analyzing total LH concentrations in urine samples. Initial increases in nocturnal total U-LH concentrations occurred around 9-10 years old in both sexes, with a longer lag time from puberty onset to gonadotropin secretion in boys.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Psychiatry
Mikkel Kjaer Bahnsen, Christian Graugaard, Kirsten Arntz Boisen, Josefine Bernhard Andresen, Mikael Andersson, Morten Frisch
Summary: Mental health problems are common among adolescents and young adults, and their associations with sexuality have been sparsely researched. This study aimed to investigate the association between mental health problems and various sexual outcomes in this population. The results showed that female AYA treated for mental health problems had more active sex lives, but also reported higher rates of sexual dysfunctions, early sexual debut, high partner numbers, sexual victimization, unsafe sex, and other sexual adversities. AYA treated for mental health problems constitute a vulnerable group at increased risk of adverse sexual outcomes. Healthcare professionals should acknowledge and address these challenges in order to reduce the risk for this group.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Endocrinology & Metabolism
Casper P. P. Hagen, Margit Bistrup Fischer, Gylli Mola, Theis Bech Mikkelsen, Line Hartvig Cleemann, Claus Hojbjerg Gravholt, Mette H. H. Viuff, Anders Juul, Anette Tonnes Pedersen, Katharina Maria Main
Summary: Turner syndrome (TS) is a chromosomal disorder characterized by the absence of the second X chromosome, affecting about 1 in 2500 female births. TS is associated with primary ovarian insufficiency (POI), with only a small percentage of women achieving pregnancy without egg donation. This review evaluates the clinical use of ovarian function markers in TS patients and reports on the transition from pediatric to gynecological and adult endocrinological care in a Danish center.
FRONTIERS IN ENDOCRINOLOGY
(2023)