Article
Biochemistry & Molecular Biology
Yi Zhai, Si-Ping Deng, Jian-Ye Liu, Dong-Neng Jiang, Yang Huang, Chun-Hua Zhu, Guang-Li Li, Ming-Hui Li
Summary: The study found that Lpxrfa in spotted scat may play a role in regulating reproduction and have significant impact on the hypothalamo-pituitary-gonadal axis.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Marie L. Ljubicic, Alexander S. Busch, Emmie N. Upners, Margit B. Fischer, Jorgen H. Petersen, Lars L. Raket, Hanne Frederiksen, Trine H. Johannsen, Anders Juul, Casper P. Hagen
Summary: This study aimed to establish continuous reference ranges for commonly used reproductive hormones in female infants and revealed a biphasic and prolonged female minipuberty.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Andrology
Kai Quin Chan, Claire Stewart, Neil Chester, Sareena H. Hamzah, Ashril Yusof
Summary: A study found that Eurycoma longifolia supplementation can increase testosterone levels in young males, mainly through activation of the hypothalamic-pituitary-adrenal axis, with a lesser role in activating the hypothalamic-pituitary-gonadal axis.
Article
Multidisciplinary Sciences
Angelica Gualtieri, Nikolina Kyprianou, Louise C. Gregory, Maria Lillina Vignola, James G. Nicholson, Rachael Tan, Shin-ichi Inoue, Valeria Scagliotti, Pedro Casado, James Blackburn, Fernando Abollo-Jimenez, Eugenia Marinelli, Rachael E. J. Besser, Wolfgang Hoegler, I. Karen Temple, Justin H. Davies, Andrey Gagunashvili, Iain C. A. F. Robinson, Sally A. Camper, Shannon W. Davis, Pedro R. Cutillas, Evelien F. Gevers, Yoko Aoki, Mehul T. Dattani, Carles Gaston-Massuet
Summary: Mutations in BRAF and other components of the MAP kinase pathway are associated with RASopathies, leading to congenital syndromes such as Septo-Optic Dysplasia and Cardio-Facio-Cutaneous syndrome. The gain-of-function mutations in BRAF are shown to play a critical role in the development of the hypothalamo-pituitary axis, resulting in endocrine deficiencies in patients with RASopathies.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Chong Li, Yanfang Cao, Yangguang Ren, Yudian Zhao, Xing Wu, Sujin Si, Jing Li, Qi Li, Na Zhang, Donghua Li, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Ruirui Jiang, Yadong Tian
Summary: This study investigated the correlation between adiponectin levels and reproductive hormones in laying hens. The results showed a significant correlation between adiponectin and reproductive hormones in the hypothalamic-pituitary-ovarian (HPO) axis. AdipoRon, an activator of adiponectin receptors, was found to promote the secretion of reproductive hormones and enhance the expression of genes related to follicle and testicular development.
Article
Environmental Sciences
Giulia Guarnieri, Matteo Becatti, Roberta Squecco, Paolo Comeglio, Rachele Garella, Lara Tamburrino, Sara Marchiani, Linda Vignozzi, Gabriella Barbara Vannelli, Mario Maggi, Annamaria Morelli
Summary: The neuroendocrine control of reproduction is regulated by the pulsatile release of GnRH by hypothalamic neurons. BaP, a pollutant, can disrupt endocrine function and affect gonadal function and gamete maturation. This study found that BaP alters the phenotype and function of GnRH neurons by interfering with KISS1R signaling and GnRH secretion, highlighting its importance in the central neuroendocrine control of reproduction.
ENVIRONMENTAL POLLUTION
(2023)
Article
Oncology
Ramadevi Subramani, Adriana Estrada, Madeline Dixon, Maria Parada, Sheryl Rodriguez, Diego A. Pedroza, Matthew D. Ramirez, Alexa Clift, Lilia Garcia, Rajkumar Lakshmanaswamy
Summary: Early pregnancy reduces the lifetime risk of breast cancer by persistently altering the hypothalamic-pituitary hormonal axis, although the exact physiological mechanisms involved are not clear.
Article
Environmental Sciences
Yongquan Yu, Di Zhang, Jiayi Xu, Daiwei Zhang, Liu Yang, Rong Xia, Shou-Lin Wang
Summary: This study investigates the association between acrylamide (AA) and sex hormones, particularly in adolescents. The findings suggest a negative correlation between AA and sex hormones, and indicate that AA can disrupt the hypothalamic-pituitary-gonadal (HPG) axis and injure gonadotropin-releasing hormone (GnRH) neurons, leading to reduced testosterone and estradiol levels in puberty.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Andrology
Gozde Gormus, Sinem Ilgin, Merve Baysal, Abdullah Burak Karaduman, Volkan Kilic, Gozde Aydogan-Kilic, Onur Karagoz, Ozlem Atli-Eklioglu
Summary: The study demonstrated that RIS may cause reproductive toxicity in male rats through inducing oxidative stress and disrupting hormonal regulation.
Article
Endocrinology & Metabolism
Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N. Upners, Margit Bistrup Fischer, Lars Lau Raket, Hanne Frederiksen, Jakob Albrethsen, Trine Holm Johannsen, Casper P. Hagen, Anders Juul
Summary: The male hypothalamic-pituitary-gonadal axis is transiently active during the first months of life, with surging serum concentrations of reproductive hormones, a period known as minipuberty. In healthy male infants, reproductive hormone concentrations show marked dynamics during the first 6 months, with correlations with testicular volume and establishment of reference curves for serum levels of reproductive hormones.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Cynthia Dela Cruz, Cassandra A. Horton, Kelsey N. Sanders, Nathan D. Andersen, Pei-San Tsai
Summary: The study found that Fgfr1 signaling directly supports reproductive axis function to some extent in GnRH neurons, but is not critically required for pubertal onset or reproductive maintenance in sexually mature animals.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Cynthia N. Ikeji, Isaac A. Adedara, Ebenezer O. Farombi
Summary: This study investigated the impact of myricetin on atrazine-induced reproductive dysfunction and found that myricetin can alleviate the effects of atrazine on the reproductive axis through anti-inflammatory and antioxidant mechanisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Maria Cruz Sueiro, Maria G. Palacios, Vance L. Trudeau, Gustavo M. Somoza, Cynthia A. Awruch
Summary: This study found that the reproductive health of fish in South American environments is affected by anthropogenic pollution, with different effects observed in different species, sexes, and seasons. The findings highlight the importance of considering multiple reproductive parameters to better understand the impacts of human activities on wild animals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Shih-Min Hsia, Yi-Fen Chiang, Hsin-Yuan Chen, Mohamed Ali, Paulus S. Wang, Kai-Lee Wang
Summary: The study found that a high-fructose diet can lead to decreased plasma testosterone levels in rats, affecting the responsiveness of Leydig cells to hormones and the activity of the hypothalamus-pituitary-gonadal (HPG) axis.
Article
Endocrinology & Metabolism
Zuleyha Karaca, Ashley Grossman, Fahrettin Kelestimur
Summary: The HPA axis is essential for maintaining normal physiological events and survival, with cortisol playing a key role. While a correct diagnosis of AI can often be made with basal cortisol levels, more complicated tests may be necessary for SAI cases. Numerous studies have been published on assessing the HPA axis, with detailed discussions and recommendations for diagnosing secondary AI or investigating suspected HPA axis insufficiency.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Obstetrics & Gynecology
Mette Jorgensen Langergaard, Andreas Ernst, Nis Brix, Anne Gaml-Sorensen, Sandra S. Tottenborg, Jens Peter E. Bonde, Gunnar Toft, Karin S. Hougaard, Cecilia H. Ramlau-Hansen
Summary: This study found that later maternal age at menarche was associated with impaired semen characteristics, lower testes volume, and altered levels of reproductive hormones in sons. However, earlier maternal age at menarche was not strongly associated with reproductive outcomes in sons. These findings may suggest a shared heritability or underlying epigenetic profile of reproductive health, but the exact mechanism remains unknown.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Jesus Catienas, Liv la Cour Poulsen, Linn Salto Mamsen, Claus Yding Andersen
Summary: In several mammalian species, oocytes from small antral follicles after in vitro maturation (IVM) are successfully used for procreation. Humans are the exception, mainly due to limited access to immature oocytes and unique regulation of oocyte maturation. However, recent findings suggest that human IVM can be developed, with factors such as oocyte diameter, follicle size, hormone levels, and cumulus-oocyte complex secretion influencing the maturation process. Furthermore, studies on signal transduction pathways and hormone levels during physiological conditions provide new insights for improving the current IVM platform. With continued research efforts, it is envisioned that a human IVM platform equally effective as in other mammalian species can be achieved. (Fertil Sterile 2023;119:550-9. (c) 2023 by American Society for Reproductive Medicine.)
FERTILITY AND STERILITY
(2023)
Article
Andrology
Anne Gaml-Sorensen, Nis Brix, Birgit Bjerre Hoyer, Sandra Sogaard Tottenborg, Karin Sorig Hougaard, Jens Peter Ellekilde Bonde, Pernille Jul Clemmensen, Andreas Ernst, Linn Hakonsen Arendt, Sjurdur Frodi Olsen, Charlotta Granstrom, Tine Brink Henriksen, Gunnar Toft, Cecilia Host Ramlau-Hansen
Summary: This study aimed to investigate the association between maternal folate intake during pregnancy and markers of fecundity in young men. The results showed that lower maternal folate intake was associated with lower sperm count and testes volume in adult men, but also with a lower proportion of non-progressive and immotile spermatozoa. Further investigation is needed to determine if this affects the ability to achieve pregnancy.
Article
Andrology
Mette Moller Dornfeldt, Anne-Marie Nybo Andersen, Karin Sorig Hougaard, Cecilia Host Ramlau-Hansen, Gunnar Toft, Jens Peter Ellekilde Bonde, Katia Keglberg Haervig, Kajsa Ugelvig Petersen, Ane Berger Bungum Kofoed, Laura Deen, Sandra Sogaard Tottenborg
Summary: A study found no strong associations between maternal fever during pregnancy and male reproductive health in young men, including timing, duration, and temperature of the fever. Concurrent use of antipyretics and antibiotics did not modify the association.
Article
Cardiac & Cardiovascular Systems
Louise F. Udholm, Linn H. Arendt, Ulla B. Knudsen, Cecilia H. Ramlau-Hansen, Vibeke E. Hjortdal
Summary: This study evaluated the fertility of men and women with congenital heart disease (CHD) and found that those with simple or moderate CHD were not at an increased risk of infertility compared to the general population. However, individuals with CHD were more likely to be childless, but those who became parents had the same number of children as parents without CHD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Anne Gaml-Sorensen, Nis Brix, Katia Keglberg Haervig, Christian Lindh, Sandra Sogaard Tottenborg, Karin Sorig Hougaard, Birgit Bjerre Hoyer, Andreas Ernst, Linn Hakonsen Arendt, Pernille Jul Clemmensen, Jens Peter Ellekilde Bonde, Tine Brink Henriksen, Gunnar Toft, Onyebuchi A. A. Arah, Cecilia Host Ramlau-Hansen
Summary: Maternal vitamin D levels during pregnancy may have an impact on reproductive health in male offspring, affecting testes volume and total sperm count. This study found that lower maternal vitamin D levels during pregnancy were associated with decreased testes volume and lower total sperm count in adult sons. The findings were supported by continuous models, spline plots, and instrumental variable analysis. Maternal vitamin D levels above 75 nmol/L during pregnancy may be beneficial for testes function in adult sons.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Nis Brix, Anne Gaml-Sorensen, Andreas Ernst, Linn Hakonsen Arendt, Lea Lykke Harrits Lunddorf, Gunnar Toft, Sandra S. Tottenborg, Katia Keglberg Haervig, Birgit Bjerre Hoyer, Karin S. Hougaard, Jens Peter E. Bonde, Cecilia Host Ramlau-Hansen
Summary: The timing of puberty is associated with semen characteristics, testicular volume, and reproductive hormone levels.
FERTILITY AND STERILITY
(2023)
Article
Public, Environmental & Occupational Health
Anne Gaml-Sorensen, Nis Brix, Andreas Ernst, Lea Lykke Harrits Lunddorf, Christian Lindh, Gunnar Toft, Tine Brink Henriksen, Onyebuchi A. Arah, Cecilia Host Ramlau-Hansen
Summary: This study investigated whether the season of first trimester or maternal 25-hydroxyvitamin D-3 levels were associated with pubertal timing in children. The results showed that children of mothers who had their first trimester during November-April or had lower 25(OH)D-3 levels had earlier pubertal timing.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Anne Gaml-Sorensen, Nis Brix, Lea Lykke Harrits Lunddorf, Andreas Ernst, Birgit Bjerre Hoyer, Sjurdur Frodi Olsen, Charlotta Granstrom, Gunnar Toft, Tine Brink Henriksen, Cecilia Host Ramlau-Hansen
Summary: A study found that maternal intake of folate during pregnancy was not associated with pubertal timing in girls, but it was slightly later in boys. The minor delay is unlikely to be clinically significant.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Review
Obstetrics & Gynecology
Marie Brond, Kjerstine Breintoft, Axel Forman, Tine Brink Henriksen, Cecilia Host Ramlau-Hansen, Dorte Rytter, Linn Hakonsen Arendt
Summary: This study systematically reviewed and meta-analyzed the association between measures of fetal growth and preterm birth and the risk of endometriosis and adenomyosis in adult life. The results showed that low birthweight and preterm birth were associated with an increased risk of endometriosis, but the evidence for adenomyosis was limited. The findings suggest a potential early programming effect of endometriosis, but further research is needed.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Cardiac & Cardiovascular Systems
Louise F. Udholm, Ninna H. Ebdrup, Linn H. Arendt, Ulla B. Knudsen, Vibeke E. Hjortdal, Cecilia H. Ramlau-Hansen
Summary: This nationwide cohort study evaluated the risk of impaired fertility in women with congenital heart disease (CHD) compared with unaffected women. The results showed that women with CHD did not have an increased risk in time to pregnancy (TTP).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Pernille Jul Clemmensen, Nis Brix, Jorg Schullehner, Andreas Ernst, Lea Lykke Harrits Lunddorf, Anne Ahrendt Bjerregaard, Thorhallur Ingi Halldorsson, Sjurdur Frodi Olsen, Birgitte Hansen, Leslie Thomas Stayner, Henrik Albert Kolstad, Torben Sigsgaard, Cecilia Host Ramlau-Hansen
Summary: This study investigated the association between prenatal exposure to nitrosatable drugs and timing of puberty, and found no significant association between the two. Sub-analyses examining different subtypes of nitrosatable drugs, dose-dependency, and the potential effect of maternal intake of nitrate, nitrite, and antioxidants also yielded null findings. This research suggests that prenatal exposure to nitrosatable drugs does not appear to impact the timing of puberty in children.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Review
Public, Environmental & Occupational Health
Pernille Jul Clemmensen, Jorg Schullehner, Nis Brix, Torben Sigsgaard, Leslie Thomas Stayner, Henrik Albert Kolstad, Cecilia Host Ramlau-Hansen
Summary: Recently, several epidemiological studies have investigated the potential health effects of prenatal exposure to nitrate, even at levels below the current drinking water standard. The reviewed studies showed indications of increased risk of preterm delivery, lower birth weight, birth defects, and childhood cancer related to prenatal nitrate exposure. However, more studies are needed to confirm these findings and explore the impact of other factors such as water consumption and diet.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2023)
Review
Public, Environmental & Occupational Health
Mette J. Langergaard, Andreas Ernst, Nis Brix, Lea L. H. Lunddorf, Cecilia H. Ramlau-Hansen
Summary: The purpose of this study is to review recent epidemiological studies published from 2017 to 2022 on the potential associations between prenatal exposure to parental lifestyle factors, diseases, and medication use and pubertal development in sons. The reviewed studies found that maternal pre-pregnancy obesity and smoking during pregnancy may be associated with earlier pubertal development in sons, while the association between paternal obesity and timing of puberty was less clear. Maternal alcohol consumption may be associated with later pubertal development in sons. Maternal gestational diabetes mellitus was associated with faster pubertal development in terms of growth, but no association was found with other markers of pubertal timing. Recent studies also reported earlier timing of puberty in sons born to mothers with hyperthyroidism and mothers accidentally using oral contraceptives during early pregnancy. No other explored prenatal exposures were associated with pubertal development in sons.
CURRENT EPIDEMIOLOGY REPORTS
(2023)
Article
Obstetrics & Gynecology
Anne Gaml-Sorensen, Anne Hjorth Thomsen, Sandra Sogaard Tottenborg, Nis Brix, Karin Sorig Hougaard, Gunnar Toft, Siri Eldevik Haberg, Mikko Myrskyla, Jens Peter Bonde, Cecilia Host Ramlau-Hansen
Summary: The maternal pre-pregnancy BMI was associated with altered reproductive hormone profile in young adult sons, characterized by higher levels of estradiol, LH, and free androgen index, and lower levels of sex hormone-binding globulin. The effects of maternal pre-pregnancy BMI on hormone levels may be partly mediated by sons' birthweight, fat mass, and BMI.
HUMAN REPRODUCTION
(2023)
