Article
Endocrinology & Metabolism
Cristian Iorga, Cristina Raluca Iorga, Iuliana Andreiana, Iustinian Bengulescu, Traian Constantin, Victor Strambu
Summary: After analyzing the obtained results, it was concluded that total parathyroidectomy is the preferred intervention for patients with secondary hyperparathyroidism when pharmacotherapy fails, in order to prevent disease recurrence and correct metabolic parameters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Geng-He Chang, Fong-Fu Chou, Ming-Shao Tsai, Yao-Te Tsai, Ming-Yu Yang, Ethan Huang, Hui-Chen Su, Cheng-Ming Hsu
Summary: Patients with end-stage renal disease may develop secondary hyperparathyroidism, which affects vocal cord muscle contraction and voice, increasing the risk of vocal dysfunction. SHPT is identified as an independent risk factor for voice disorders in ESRD patients, mainly impacting acoustic factors.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Babak J. Orandi, Cora E. Lewis, Paul A. MacLennan, Haiyan Qu, Shikha Mehta, Vineeta Kumar, Saulat S. Sheikh, Robert M. Cannon, Douglas J. Anderson, Michael J. Hanaway, Rhiannon D. Reed, A. Cozette Killian, Joshua W. Purvis, Norah A. Terrault, Jayme E. Locke
Summary: This study found that around 40,000 dialysis patients with obesity as their only transplant contraindication were less likely to be wait-listed and, for those who were, had a lower likelihood of transplant.
Article
Nutrition & Dietetics
Eun Hui Bae, Tae Ryom Oh, Sang Heon Suh, Eun Mi Yang, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim
Summary: Weight variability is known to be a risk factor for cardiovascular events and mortality. This study investigated the relationship between weight change and the risk of end-stage renal disease (ESRD). The findings showed that both weight loss and weight gain of 10% or more were associated with a higher risk of ESRD compared to a weight change of less than 5%.
Article
Cardiac & Cardiovascular Systems
Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Summary: This study found that hypertension control is associated with the risk of end-stage renal disease in newly diagnosed atrial fibrillation patients, emphasizing the importance of blood pressure control once patients are diagnosed with AF to prevent ESRD.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Wonyoung Jung, Junhee Park, Hye Ryoun Jang, Junseok Jeon, Kyungdo Han, Bongseong Kim, Je Moon Yoon, Dong Hui Lim, Dong Wook Shin
Summary: This study investigated the association between age-related macular degeneration (AMD) and end-stage renal disease (ESRD) risk using a large cohort in Korea. The results showed that people with AMD had a 33% increased risk of ESRD, and the risk was even higher when accompanied by visual disability.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
Ghulam Rehman Mohyuddin, Aynharan Sinnarajah, Anastasia Gayowsky, Kelvin K. W. Chan, Hsien Seow, Hira Mian
Summary: Optimizing end-of-life care for multiple myeloma is still needed. A study in Ontario, Canada analyzed an administrative cohort between 2006 and 2018, finding that many patients still receive aggressive care at the end of life, but the adoption of supportive care has increased. Age, income, and community size were identified as factors influencing the receipt of supportive care.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, General & Internal
Shih-Yi Lin, Cheng-Li Lin, Wu-Huei Hsu, Cheng-Chieh Lin, Sui-Foon Lo, Chia-Hung Kao
Summary: This study found that patients with ESRD have a significantly higher risk of idiopathic polyneuropathy compared to the control group. Patients with ESRD and carpal tunnel syndrome had a higher incidence of idiopathic peripheral neuropathy than those with ESRD but without carpal tunnel syndrome.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Oak-Kee Hong, Hyuk-Sang Kwon
Summary: This study investigated the impact of changes in MetS components on ESRD using data from the Korean National Health Insurance System. The results showed that individuals with MetS components had a higher risk of developing ESRD, especially in those with impaired renal function.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ying-Chang Tung, Chi-Jen Chang, Jia-Rou Liu, Shu-Hao Chang, Yi-Hsin Chan, Chi-Tai Kuo, Lai-Chu See
Summary: The study found that among hemodialysis patients receiving DAPT for AMI, ticagrelor was comparable to clopidogrel in terms of the composite efficacy endpoint and bleeding.
SCIENTIFIC REPORTS
(2021)
Article
Neuroimaging
Kuo-Wei Chen, Chih-Hao Chen, Yen-Heng Lin, Chung-Wei Lee, Kun-Chang Tsai, Li-Kai Tsai, Sung-Chun Tang, Jiann-Shing Jeng
Summary: This study investigated the outcome of endovascular thrombectomy in patients with end-stage renal disease (ESRD). The results showed that ESRD-dialysis patients had more adverse events and worse outcomes. Patients with premorbid functional dependency also had a higher mortality rate.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Allison E. Gaffey, Lindsey Rosman, Matthew M. Burg, Sally G. Haskell, Cynthia A. Brandt, Melissa Skanderson, James Dziura, Jason J. Sico
Summary: The study revealed that the use of SSRI antidepressants was associated with a 45% increased risk of hemorrhagic stroke, while the effects of PTSD and SNRI were weaker. Factors such as hypertension, drug abuse, and alcohol abuse were linked to an increased stroke risk, while nonobesity and being non-Hispanic were protective.
Article
Dentistry, Oral Surgery & Medicine
Kyungdo Han, Jun-Beom Park
Summary: The study suggests an association between oral health, depicted by number of natural teeth, and the increased risk of kidney diseases. The risk of end-stage renal disease was found to be higher with lower number of natural teeth and longer follow-up periods. Factors such as age, body mass index, and smoking status were also significantly associated with this relationship.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Peripheral Vascular Disease
Eun Hui Bae, Sang Yeob Lim, Bongseong Kim, Tae Ryom Oh, Su Hyun Song, Sang Heon Suh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Summary: This study found that higher blood pressure is associated with an increased risk of end-stage renal disease (ESRD) in patients with diabetes. The risk is particularly higher in younger individuals. Age, sex, use of antihypertensive medication, and history of chronic kidney disease have different effects on the risk of ESRD.
Article
Biochemistry & Molecular Biology
Fang-Ju Cheng, Chia-Hung Chen, Wen-Chen Tsai, Bo-Wei Wang, Meng-Chieh Yu, Te-Chun Hsia, Ya-Ling Wei, Yu-Chun Hsiao, Dai-Wei Hu, Chien-Yi Ho, Tzong-Shiun Li, Chun-Yi Wu, Wen-Yu Chou, Yung-Luen Yu, Chih-Hsin Tang, Chih-Yi Chen, Chuan-Mu Chen, Jennifer L. Hsu, Hsiao-Fan Chen, Yeh Chen, Chih-Yen Tu, Mien-Chie Hung, Wei-Chien Huang
Summary: Smokers with non-small cell lung cancer have lower sensitivity to EGFR tyrosine kinase inhibitors, as exposure to cigarette smoke extract enhances glycolysis and weakens the inhibition of mTOR by AMPK, thus reducing the sensitivity of NSCLC cells to EGFR TKI by repressing LKB1 expression. Additionally, LKB1 expression is positively correlated with TKI sensitivity in NSCLC patients, and combined treatment with EGFR TKI and AMPK activators increases TKI sensitivity synergistically.
Article
Environmental Sciences
Hsiu-Ling Huang, Chuan-Yu Kung, Shun-Mu Wang, Pei-Tseng Kung, Yen-Hsiung Lin, Li-Ting Chiu, Wen-Chen Tsai
Summary: The study found that diabetes patients with lower BMI had higher mortality rates, while participation in the P4P program could lower the risk of death, especially in the underweight or obese groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Chun-Ming Liao, Wen-Hao Huang, Pei-Tseng Kung, Li-Ting Chiu, Wen-Chen Tsai
Summary: This study aimed to investigate the differences in the probability of colorectal cancer screening with faecal immunochemical testing between people with disability and without disability in Taiwan. The results showed that people with disability were less likely than people without disability to undergo CRC screening, indicating health inequalities exist under National Health Insurance in Taiwan.
Article
Multidisciplinary Sciences
Chao-Ping Chen, Pei-Tseng Kung, Wen-Yu Chou, Wen-Chen Tsai
Summary: The study found no significant differences in risk were observed between the use of conventional DMARDs and biologics in patients with rheumatoid arthritis in terms of venous thromboembolism (VTE).
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Chun-Ming Liao, Wei-Yin Kuo, Pei-Tseng Kung, Chuang-Hui Chuan, Wen-Chen Tsai
Summary: This study examined the epidemiology and medical utilization of multiple sclerosis (MS) patients in Taiwan using the National Health Insurance Research Database from 2001 to 2015. The standardized prevalence of MS steadily increased during this period, reaching a peak of 7.14/100,000 in 2015. The number of emergency visits peaked in 2011 and the average length of hospital stays decreased from 19.2 days in 2001 to 5.6 days in 2015.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Oncology
Fung-Chang Sung, Yi-Ting Yeh, Chih-Hsin Muo, Chih-Cheng Hsu, Wen-Chen Tsai, Yueh-Han Hsu
Summary: This study examined the association between statin therapy and the risk of liver cancer in hyperlipidemic patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). The results showed that patients receiving statin therapy had a reduced risk of liver cancer, especially those with normal renal function and those using hydrophilic statins or statin-ezetimibe combination therapy. The study also highlighted the effectiveness of ezetimibe as a treatment option for hyperlipidemia.
Article
Environmental Sciences
Puchong Inchai, Wen-Chen Tsai, Li-Ting Chiu, Pei-Tseng Kung
Summary: Women with disabilities are less likely to undergo breast cancer screening, particularly those with dementia, multiple disabilities, or intellectual disabilities.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Fung-Chang Sung, Ying-Chin Jong, Chih-Hsin Muo, Chih-Cheng Hsu, Wen-Chen Tsai, Yueh-Han Hsu
Summary: Through analyzing insurance claims data from Taiwan, we found that statin therapy may reduce mortality risks for hyperlipidemic patients, especially in those with end-stage renal disease. Hydrophilic statin therapy showed superior effects in reducing all-cause mortality and deaths from cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Tai-Yi Hsu, Jhu-Jing Ye, Sih-Yun Ye, Hsiao-Yuan Tseng, Wen-Yu Chou, Pei-Tseng Kung, Wen-Chen Tsai
Summary: Liver cancer is a major health concern in Taiwan, but the government does not include it in its free cancer screening services. This study found significant differences in cancer stage and survival between patients diagnosed with liver cancer in outpatient departments versus emergency departments.
Article
Public, Environmental & Occupational Health
Wen -Chen Tsai, Kuang-Hua Huang, Pei -Chun Chen, Yu -Chia Chang, Michael S. Chen, Chiachi Bonnie Lee
Summary: This study investigated the impact of individual and neighborhood social risks on exclusion from and adherence to a diabetes pay-for-performance (P4P) program for patients with type 2 diabetes in Taiwan. The results showed that patients with higher individual social risks were more likely to be excluded from the program, while those with higher neighborhood-level social risks were slightly less likely to be excluded. Patients with higher individual or neighborhood social risks also had lower adherence to the program. Therefore, disease-specific P4P programs should consider individual social risk adjustment and special financial incentives to improve program adherence.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Health Care Sciences & Services
Chia-Yu Chen, Pei-Tseng Kung, Li-Ting Chiu, Wen-Chen Tsai
Summary: There is a significant difference in the utilization of Pap smear tests between individuals with disabilities and those without disabilities in Taiwan, with a lower percentage of individuals with disabilities receiving the test. It is crucial to recognize the unique needs of individuals with disabilities, especially those with cognitive impairments.
Article
Health Care Sciences & Services
Chun-Ming Liao, Chia-Yu Chen, Pei-Tseng Kung, Wei-Yin Kuo, Hui-Chuan Chuang, Wen-Chen Tsai
Summary: Despite the global decline in MS mortality rate, limited research has been conducted on MS patient survival in Taiwan. This study analyzed data from 1444 MS patients and found that age at diagnosis was positively correlated with the risk of death. The leading causes of disease-related deaths among the 190 patients who died were nervous system diseases, followed by respiratory system diseases and certain infectious and parasitic diseases. The study also concluded that socioeconomic status, environmental factors, comorbidity severity, and related medical variables were not significantly associated with MS patient survival.
Article
Health Care Sciences & Services
Wei-Yin Kuo, Wen-Chen Tsai, Pei-Tseng Kung
Summary: People with disabilities are less likely to participate in the diabetes pay-for-performance program in Taiwan and have unequal access to care. However, the program is more effective at reducing mortality among people with disabilities compared to those without.
Article
Health Care Sciences & Services
Yi-Shu Liao, Wen-Chen Tsai, Li-Ting Chiu, Pei-Tseng Kung
Summary: This study found a relationship between educational attainment and the risk of diabetes complications and mortality. The results showed that higher educational attainment was associated with a lower risk of diabetes complications at diagnosis.
Article
Environmental Sciences
Wei-Yin Kuo, Han-Sheng Hsu, Pei-Tseng Kung, Wen-Chen Tsai
Summary: The study found that socioeconomic status significantly impacts the risk of colorectal cancer and patient survival, with education level being a key determinant of both incidence risk and survival. However, only income had a significant impact on the risk of developing colorectal cancer.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)