期刊
MEDICINE
卷 94, 期 23, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000000901
关键词
-
资金
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [15H04806] Funding Source: KAKEN
Alpha-fetoprotein (AFP) has not played a large role in the surveillance of hepatocellular carcinoma due to inadequate sensitivity and specificity for active chronic hepatitis or cirrhosis. The aim of this study was to evaluate the diagnostic accuracy of AFP in small hepatocellular carcinomas after hepatitis C virus eradication to determine the optimal cutoff value.We conducted a case-control study of 29 cases and 58 controls, matched for age, gender, and platelet counts.The AFP cutoff was 5ng/mL in patients after hepatitis C virus eradication and 17ng/mL in those without hepatitis C virus eradication. The areas under the receiver operating characteristic curve were 0.86 (95% confidence interval, 0.76-0.96) in patients after hepatitis C virus eradication and 0.83 (95% confidence interval, 0.74-0.91) in those without hepatitis C virus eradication. In patients after hepatitis C virus eradication, the sensitivity and specificity of AFP levels were 24.1% and 100%, respectively, using a cutoff value of 17ng/mL. Using a lower cutoff value of 5ng/mL, the sensitivity increased to 75.9%, although the specificity decreased to 89.0%.AFP is a specific tumor marker for the diagnosis of hepatocellular carcinoma after hepatitis C virus eradication when using the optimal cutoff value of 5ng/mL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据