Article
Nutrition & Dietetics
Arzu Kabasakal Cetin, Yucel Buyukdere, Atila Gulec, Asli Akyol
Summary: Maternal taurine supplementation can reduce adiposity and alter hepatic gene expression patterns, mitigating the detrimental effects of maternal obesogenic diet on offspring. The offspring supplemented with taurine showed lower fat deposition and body fat compared to those without supplementation. Genes related to steroid hormone biosynthesis, cholesterol metabolism, and fatty acid degradation were down-regulated in the taurine-supplemented offspring.
NUTRITION RESEARCH
(2023)
Article
Nutrition & Dietetics
Samia Squizani, Jeferson Jantsch, Fernanda da Silva Rodrigues, Matheus Filipe Braga, Sarah Eller, Tiago Franco de Oliveira, Alexandre Kleber Silveira, Jose Claudio Fonseca Moreira, Marcia Giovenardi, Marilene Porawski, Renata Padilha Guedes
Summary: This study aimed to evaluate the effects of zinc supplementation on the intestinal microbiota, fatty acid profile, and neurofunctional parameters in obese rats. The findings showed that zinc supplementation did not protect obese animals from intestinal dysbiosis, but an increase in acetate levels was observed, suggesting a partial beneficial effect of zinc.
Article
Nutrition & Dietetics
Veronica Arreaza-Gil, Ivan Escobar-Martinez, Manuel Suarez, Francisca Isabel Bravo, Begona Muguerza, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: Gut microbiota and biological rhythms are key factors that affect physiological and metabolic processes. This study found that seasonal changes in photoperiod significantly altered gut microbiota composition and influenced diet-induced obesity development.
Article
Food Science & Technology
Hatice Ozcaliskan Ilkay, Derya Karabulut, Gonca Kamaci Ozocak, Ecmel Mehmetbeyoglu, Emin Kaymak, Betul Kisioglu, Betul Cicek, Asli Akyol
Summary: The study aimed to investigate the protective effects of quinoa in glucose homeostasis in a model of cafeteria diet-induced obesity. Results showed that quinoa lowered body weight, blood glucose, and insulin levels, increased liver IRS-1 and AMPK gene expressions, and enhanced pancreatic beta-cell insulin immunoreactivity. Quinoa may be useful in preventing obesity and associated metabolic disorders.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Andreu Gual-Grau, Maria Guirro, Noemi Boque, Lluis Arola
Summary: Genetic factors and sex can influence the gut microbiota composition and obesity status of rats fed a CAF diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biology
Syed Mohammed Basheeruddin Asdaq, Shrey Tambe, Yahya Mohzari, Ahmed Alrashed, Hamdan Najib Alajami, Awad Othman Aljohani, Abdullah Ali Al Mushtawi, Majed Sultan Alenazy, Rakan Fahad Alamer, Abdulmajead Khalid Alanazi, Syed Imam Rabbani
Summary: This study evaluated the anti-obesity potential of almonds under different dietary conditions. Results showed that almond can prevent weight gain, improve lipid parameters, and stabilize CNS parameters. The high dose almond preparation was most effective in reducing body weight.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jakub Poloczek, Wojciech Kazura, Elzbieta Chelmecka, Katarzyna Michalczyk, Jerzy Jochem, Janusz Gumprecht, Dominika Stygar
Summary: Over-nutrition leads to glycemic control failure and obesity, which can be mitigated by bariatric surgery and specific dietary protocol. The study measured the levels of antioxidant markers and lipid peroxidation markers in rats fed with different diets and subjected to surgery. The results showed that the diet change strongly influenced antioxidant marker activity, while bariatric surgery had a greater effect on superoxidase dismutase activity. All dietary protocols increased ceruloplasmin activity, and cafeteria diet decreased total antioxidant capacity levels. Bariatric surgery and no change in diet reduced lipid peroxidation and lipofuscin levels, respectively.
Article
Multidisciplinary Sciences
Chen Xu, Ning Dong, Kaichao Chen, Xuemei Yang, Ping Zeng, Changshun Hou, Edward Wai Chi Chan, Xi Yao, Sheng Chen
Summary: Vitamin C (VC) has strong bactericidal, anti-biofilm, and virulence-suppressing effects on carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP). It induces reactive oxygen species generation to kill the bacteria and inhibits biofilm formation by suppressing exopolysaccharide (EPS) production. In addition, VC acts as an efflux pump inhibitor to disrupt EPS and capsular polysaccharide transportation, further inhibiting biofilm and capsule formation. Virulence-associated genes in CR-hvKP are downregulated when exposed to sub-MIC of VC. VC could be an effective and safe therapeutic agent for urgent cases when other treatment options fail.
Article
Multidisciplinary Sciences
Arzu Kabasakal Cetin, Tugba Alkan Tug, Atila Gulec, Asli Akyol
Summary: The study showed that maternal taurine supplementation has modest protective effects against cafeteria diet-induced maternal obesity. However, in the setting of normal pregnancy, taurine supplementation may lead to increased neonatal mortality. Further research is needed to explore the optimal dosage of taurine supplementation and its long-term effects on offspring.
Article
Multidisciplinary Sciences
Marianela Andrea Diaz Urrutia, Amanda Gemelli Ramos, Rafaela Beatriz Menegusso, Rafael Dewes Lenz, Mateus Gemelli Ramos, Adriana Gadioli Tarone, Cinthia Bau Betim Cazarin, Solange Maria Cottica, Sostenez Alexandre Vessaro da Silva, Daniela Miotto Bernardi
Summary: The supplementation of kombucha and green banana flour did not prevent the lipid and liver profile changes caused by a cafeteria diet in Wistar rats. However, it did lead to less weight gain in the animals.
Article
Biochemistry & Molecular Biology
Aynaz Tajaddini, Michael D. Kendig, Kelly V. Prates, R. Frederick Westbrook, Margaret J. Morris
Summary: Maternal obesity increases the risk of health complications in offspring, and the effects can be exacerbated by offspring exposure to unhealthy diets. This study found that offspring from obese mothers who were fed an unhealthy "cafeteria" diet had smaller size, more abdominal fat, and altered gene expression in the liver. Additionally, maternal obesity enhanced the negative effects of postweaning unhealthy diet on male offspring, while having minimal impact on female offspring. These findings highlight the importance of understanding the sex-specific detrimental effects of maternal obesity on offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Liaqat Hussain, Saba Rana, Ghulam Abbas, Abdulrahman Alshammari, Abdullah F. Alasmari, Metab Alharbi, Muhammad Toseef Zahid, Muhammad Irfan
Summary: The commonly seen female endocrine disorder, polycystic ovarian syndrome (PCOS), which mainly affects women in their childbearing age, can be effectively managed using Hippophae rhamnoides L. and its nano-emulsion (HRNE) that showed better bioavailability. The treatment improved hormonal imbalance, lipid profile, and antioxidant markers, while also restoring ovarian echotexture and follicular development.
Article
Food Science & Technology
Nabab Khan, Amit Kumar Singh, Ankit Saneja
Summary: The study demonstrates that LAA-cyclodextrin inclusion complex-incorporated nanofibers (NFs) can improve the stability and antioxidant potential of L-Ascorbic acid (LAA). The encapsulation of LAA within HP-beta-CD cavities enhances its thermal stability and antioxidant activity. This research provides promising avenues for addressing the limitations of LAA in therapeutic and food applications.
Article
Food Science & Technology
Hang Yu, Yaxin He, Mengru Wang, Fangwei Yang, Yunfei Xie, Yahui Guo, Yuliang Cheng, Weirong Yao
Summary: The study demonstrated that DHA can be regenerated to AA in the presence of TBHQ, significantly increasing the regeneration rate of AA. The extent of regeneration is influenced by factors such as the surface area of the PE film, TBHQ content, reaction time, and temperature. Adding TBHQ to chocolate improves the antioxidant capacity of AA and may extend the shelf-life of liqueur chocolate.
Article
Food Science & Technology
Abdullah AlSaleh, Mohammed Shahid, Eman Farid, Khalid Bindayna
Summary: This study aims to investigate the effects of ascorbic acid and nicotinamide on Panton-Valentine Leukocidin (PVL) cytotoxicity and granulocyte viability. The results demonstrate that ascorbic acid and nicotinamide can reduce PVL cytotoxicity and maintain cell viability. Further research is needed to explore the potential of these antioxidants in attenuating PVL cytotoxicity in PVL-related diseases.
Article
Endocrinology & Metabolism
J. Alfredo Martinez, Franco Sassi, Luis A. Moreno, Josep A. Tur
Summary: The article highlights the seriousness of childhood obesity as a global public health issue, as well as the research collaborations and policy goals related to childhood obesity. Addressing childhood obesity requires considerations of different levels and global impacts.
Article
Endocrinology & Metabolism
Josep A. Tur, J. Alfredo Martinez
Summary: Childhood obesity is influenced by factors such as birth weight, dietary habits, and gut microbiota. Further research is needed to explore the metabolic patterns and the role of specific molecules in childhood obesity. The interaction between genes and the environment also plays a significant role in understanding the increasing rates of childhood obesity.
Review
Endocrinology & Metabolism
Begona de Cuevillas, Fermin I. Milagro, Josep A. Tur, Mercedes Gil-Campos, Pilar de Miguel-Etayo, J. Alfredo Martinez, Santiago Navas-Carretero
Summary: This review discusses various factors that impact infant intestinal microbiota, potentially affecting the rise of childhood obesity rates and the microbiota shifts associated with excessive body weight in children. Studies have linked excessive body weight to a specific profile of gut microbiota, with factors such as gestational weight gain, perinatal diet, antibiotic administration, birth delivery, and feeding patterns playing a role.
Article
Biotechnology & Applied Microbiology
Florencio Marzo, Patricia Jauregui, Jaione Barrenetxe, Ana Martinez-Penuela, Francisco C. Ibanez, Fermin Milagro
Summary: This study analyzed the effect of a diet supplemented with a combination of sphingomyelin and lactic acid-producing bacteria on mice with DMH-induced colon cancer. The results confirmed the beneficial effects of the synbiotic on the intestinal physiology and contributed to the understanding of possible mechanisms involved.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Biochemistry & Molecular Biology
Jorge G. Garcia, Carlos de Miguel, Fermin I. Milagro, Guillermo Zalba, Eduardo Ansorena
Summary: This study demonstrates the impact of endothelial NOX5 expression on neighboring adipose tissue in obesity conditions, revealing that NOX5 activity can promote thermogenesis and lipolysis in adipose tissue by regulating IL-6 production.
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Marta P. Silvestre, Mikael Fogelholm, Marta Alves, Ana Papoila, Tanja Adam, Amy Liu, Jennie Brand-Miller, Margriet Westerterp-Plantenga, Teodora Handjieva-Darlenska, Ian A. Macdonald, Ruixin Zhu, Elli Jalo, Roslyn Muirhead, Santiago Navas Carretero, Svetoslav Handjiev, Moira A. Taylor, Anne Raben, Sally D. Poppitt
Summary: This study aimed to compare the differences between HbA1c and glucose-related variables in predicting weight loss and glycemic changes in individuals with overweight and hyperglycemia. The results showed that neither HbA1c nor fasting glucose can predict short-term weight loss success, but they may impact the metabolic response to rapid weight loss.
CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Diego Martinez-Urbistondo, Ana Huerta, David Navarro-Gonzalez, Laura Sanchez-Inigo, Alejandro Fernandez-Montero, Manuel F. Landecho, J. Alfredo Martinez, Juan C. Pastrana-Delgado
Summary: The study found that metabolic syndrome (MetS), prediabetes (PreDM), and metabolic-associated fatty liver disease (MAFLD) are associated with the onset of type 2 diabetes mellitus (T2DM). The non-invasive assessment of MAFLD combined with PreDM and MetS features may provide a more accurate prediction of hyperglycemic status. The study identified five different liver status-linked phenotypes with increasing risk of T2DM.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Peripheral Vascular Disease
Minghao Kou, Xiang Li, Xiaojian Shao, Elin Grundberg, Xuan Wang, Hao Ma, Yoriko Heianza, J. Alfredo Martinez, George A. Bray, Frank M. Sacks, Lu Qi
Summary: DNAm may play a critical role in connecting prenatal adverse events and cardiometabolic disorders, including hypertension in later life. The study found that regional DNAm at LINC00319 was associated with weight loss and blood pressure reduction, suggesting that DNAm could be a metabolic memory bridging early and later life.
Article
Nutrition & Dietetics
Francisca Salas-Perez, Tais Silveira Assmann, Omar Ramos-Lopez, J. Alfredo Martinez, Jose Ignacio Riezu-Boj, Fermin I. Milagro
Summary: This study found a link between gut microbiota and DNA methylation patterns in individuals with obesity. Through DNA methylation and bacterial DNA sequencing analysis, they identified BMI-related differentially methylated DNA regions (DMRs) and bacterial genera. The abundance of Ruminococcus was found to be negatively correlated with BMI, and it was associated with a hypermethylated DMR located between the MACROD2/SEL1L2 genes. The mediation test showed that 19% of the effect of Ruminococcus abundance on BMI is mediated by the methylation of the MACROD2/SEL1L2 DMR. These findings suggest that crosstalk between gut microbiota and epigenetic markers may contribute to obesity development.
Article
Nutrition & Dietetics
Pilar Sanchis, Rafael Maria Prieto, Jadwiga Konieczna, Felix Grases, Itziar Abete, Jordi Salas-Salvado, Vicente Martin, Miguel Ruiz-Canela, Nancy Babio, Jesus Francisco Garcia-Gavilan, Albert Goday, Antonia Costa-Bauza, Jose Alfredo Martinez, Dora Romaguera
Summary: The main objective of this study was to examine the relationship between dietary phytate intake and bone mineral density (BMD) in a Mediterranean population of postmenopausal women. The results showed that phytate intake was positively associated with BMD in Mediterranean postmenopausal women, indicating a potential protective effect on bone. However, further large-scale, long-term, and randomized prospective clinical studies are needed to assess the potential benefits of phytate consumption on BMD in postmenopausal women.
Article
Nutrition & Dietetics
Cristina Valle-Hita, Andres Diaz-Lopez, Nerea Becerra-Tomas, Estefania Toledo, Isabel Cornejo-Pareja, Itziar Abete, Antoni Sureda, Maira Bes-Rastrollo, J. Alfredo Martinez, Francisco J. Tinahones, Josep A. Tur, Tany E. Garciduenas-Fimbres, Francisco Paris-Palleja, Albert Goday, Nuria Goni-Ruiz, Jordi Salas-Salvado, Nancy Babio
Summary: The consumption of ultra-processed food (UPF) is associated with a decline in kidney function, particularly among older adults. Therefore, reducing the intake of UPF is important for maintaining kidney function.
CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
O. Pano, C. Sayon-Orea, M. S. Hershey, V. de la O, C. Fernandez-Lazaro, M. Bes-Rastrollo, J. -M. Martin-Moreno, A. Sanchez-Villegas, J. A. Martinez
Summary: This study aimed to examine the association between a lifestyle assessment tool called the LWB-I and incident depression in healthy participants. The results showed that healthier lifestyles were associated with a lower risk of depression.
Article
Clinical Neurology
Magdalena Arnal Segura, Giorgio Bini, Dietmar Fernandez Orth, Eleftherios Samaras, Maya Kassis, Fotis Aisopos, Jordi Rambla De Argila, George Paliouras, Peter Garrard, Claudia Giambartolomei, Gian Gaetano Tartaglia
Summary: In this study, tree-based machine learning algorithms were used to discriminate Alzheimer's disease from unaffected individuals, leading to the identification of specific genomic profiles defined by interactions among single nucleotide variants in gene regions such as PVRL2, TOMM40, APOE, and APOC1.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)