Article
Immunology
Nosheen Basharat, Jadoon Khan, Irfan Ullah, Aamer Ali Shah, Ijaz Ali
Summary: In this study, the molecular characterization of human echinococcosis in the southern Punjab region of Pakistan was conducted. The majority of human infections were caused by E. granulosus s.s., followed by E. multilocularis and E. canadensis. Genotypic characterization among both human and livestock populations is needed to explore the genetic diversity of echinococcosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Veterinary Sciences
Ian David Woolsey, Andrea L. Miller
Summary: Echinococcus spp. have a global distribution and are of significance to human and veterinary professionals. Infections can lead to different diseases, including cystic echinococcosis and alveolar echinococcosis.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Parasitology
Huijiao Jiang, Xiaoyi Wang, Lijiao Guo, Xiaowu Tan, Xianwei Gui, Zhenyu Liao, Zhiwei Li, Xueling Chen, Xiangwei Wu
Summary: The study demonstrated that SU11248 effectively inhibited the growth of E. multilocularis metacestodes and reduced neovascular lesions. The expression of pro-angiogenic factors VEGFA, VEGFR2, and p-VEGFR2 was significantly decreased in the metacestode tissues after SU11248 treatment. It also showed some anthelmintic effects in vitro, damaging the cellular structure of the metacestodes. Moreover, SU11248 was less toxic to certain cells and completely inhibited EPC migration.
PARASITES & VECTORS
(2023)
Article
Parasitology
Jian Gao, Xuan Zhou, Ling Liu, Guodong Lv, Qiulian Hou, Xiaofan Zhang, Yujuan Shen
Summary: The study identified 5 miRNAs potentially involved in regulating the Notch pathway during PSC encystation, with EVs possibly regulating the expression of EgrG_000892700 in PSCs through continuous targeting of egr-miR-4989-3p and egr-miR-277a-3p.
PARASITES & VECTORS
(2022)
Article
Parasitology
Poleta Luga, Arben Gjata, Ilir Akshija, Ledina Mino, Valbona Gjoni, Arben Pilaca, Michael Zobi, Gabriela Equihua Martinez, Joachim Richter
Summary: Echinococcosis is a neglected zoonotic disease with a high risk to human health. In Albania, cystic echinococcosis (CE) is prevalent, but there is a lack of data to confirm this. A total of 771 CE cases were documented through systematic literature search and reviewing hospital records. Surgery was the main treatment approach. Mandatory notification should be strengthened to establish a realistic estimate of CE prevalence and incidence in Albania.
PARASITOLOGY RESEARCH
(2023)
Article
Infectious Diseases
Alexander Oberli, Lavinia Furrer, Lena Skoko, Norbert Muller, Bruno Gottstein, Pascal Bittel
Summary: The study validated a real-time PCR technique that can distinguish Echinococcus multilocularis, E. granulosus s.l., and Taenia spp. in biopsy or cytology material. Sanger sequencing of E. granulosus s.l. and Taenia spp. amplicons enables differentiation of various Echinococcus and Taenia species. The assay demonstrated high sensitivity and specificity in detecting and identifying larval cestodiases in human tissue.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Parasitology
Sebastian Miles, Javier Magnone, Joaquin Garcia-Luna, Maria Eugenia Ancarola, Marcela Cucher, Sylvia Dematteis, Friedrich Frischknecht, Marek Cyrklaff, Gustavo Mourglia-Ettlin
Summary: This study provides an in-depth characterization of the tegument of Echinococcus ortleppi protoscoleces, revealing a novel structure termed the 'tegumental vesicular body' and vesicle-like structures possibly involved in endocytic/exocytic routes. Parasite antigens were unevenly localized within tegumental structures, with both being detected in vesicles found within the TVB. The presence of host IgG suggests a possible endocytic route in protoscoleces.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Review
Parasitology
Hamidreza Ghasemirad, Nasrin Bazargan, Armita Shahesmaeili, Majid Fasihi Harandi
Summary: This study systematically reviewed the literature on echinococcosis in immunocompromised individuals. The most frequent condition in immunocompromised cystic echinococcosis (CE) patients was found to be HIV/AIDS, while malignancies were dominant in alveolar echinococcosis (AE) patients. Surgery was the common treatment approach, but a high mortality rate was observed in CE patients.
Article
Immunology
Philipp A. Kronenberg, Michael Reinehr, Ramon Marc Eichenberger, Sina Hasler, Teivi Laurimae, Achim Weber, Ansgar Deibel, Beat Muellhaupt, Bruno Gottstein, Norbert Mueller, Andrew Hemphill, Peter Deplazes
Summary: This study investigated the use of monoclonal antibodies (mAbs) for the detection and visualization of major antigens in Echinococcus multilocularis and E. granulosus s.l. The mAbs Em2G11 and EmG3 showed specific binding to the extracellular vesicles (EVs) of both species, and exhibited staining patterns specific to the laminated layer and germinal layer of the parasite. These mAbs are valuable tools for studying parasite-host interactions and pathogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Petra Bandelj, Rok Blagus, Gorazd Vengust, Diana Zele Vengust
Summary: This study molecularly tested the prevalence of Echinococcus species in Slovenian wild carnivores and found that red foxes and golden jackals were positive for Echinococcus multilocularis. The prevalence of EM was associated with the region, with higher risk of infection in central and southern Slovenia. The golden jackal may soon become an important source for human infection with EM.
Article
Microbiology
Philipp A. Kronenberg, Ansgar Deibel, Bruno Gottstein, Felix Grimm, Beat Mullhaupt, Cordula Meyer zu Schwabedissen, Sezdbek Aitbaev, Rakhatbek A. Omorov, Kubanychbek K. Abdykerimov, Gulnara Minbaeva, Jumagul Usubalieva, Mar Siles-Lucas, Paola Pepe, Laura Rinaldi, Markus Spiliotis, Junhua Wang, Norbert Mueller, Paul R. Torgerson, Peter Deplazes
Summary: This study compared the performance of different antigens and assays in the diagnosis of alveolar and cystic echinococcosis. Native antigens and three commercial tests showed high sensitivity and specificity in Swiss patients, while slightly lower values were found in Kyrgyz patients. A test combination of an E. multilocularis protoscolex antigen and the recombinant antigen Em95 appeared to be the most suitable strategy for the diagnosis of alveolar echinococcosis in Kyrgyzstan. However, the diagnosis of cystic echinococcosis was hindered by cross-reactivity with other parasitic diseases and limited sensitivity.
Article
Parasitology
Tamas Balog, Gabor Nagy, Tibor Halasz, Erika Csanyi, Zoltan Zomborszky, Agnes Csivincsik
Summary: In Europe, the golden jackal serves as an important definitive host for Echinococcus multilocularis and Echinococcus granulosus s.l., potentially promoting the spread of these parasites. Research conducted in southwestern Hungary found infections of both parasites in the dense golden jackal population, indicating a potential impact on the geographical distribution and characteristics of these helminths in different host species.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Chemistry, Applied
Mohaddeseh Abouhosseini Tabari, Amir Hossein Jafari, Filippo Maggi, Eugenia Mazzara, Mohammad Reza Youssefi, Elham Moghaddas, Mohammad Mehdi Yazdani Rostam, Fatemeh Rezaei
Summary: This study evaluated the scolicidal activity of six essential oils on Echinococcus granulosus and found that the oils of Syzygium aromaticum and Clausena anisata showed promising results for further development of therapeutics.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2022)
Article
Parasitology
Yanping Zhao, Dunzhu Gesang, Li Wan, Jiandong Li, Gezhen Qiangba, Wangmu Danzeng, Zhuoga Basang, Nibu Renzhen, Jiefang Yin, Quzhen Gongsang, Huimin Cai, Huasheng Pang, Daxi Wang, Asan, Qingda Zhang, Junhua Li, Weijun Chen
Summary: This research conducted a comprehensive molecular investigation of Echinococcus species and genotypes infecting humans in Tibet Autonomous Region (TAR). The study identified various Echinococcus species and genotypes, including the identification of the possible origin of G1 in TAR as Turkey. These findings are crucial for understanding the epidemiology and pathology of echinococcosis in TAR.
PARASITES & VECTORS
(2022)
Article
Parasitology
Mehdi Farhadi, Ali Haniloo, Kobra Rostamizadeh, Nahid Ahmadi
Summary: The study demonstrated that the ABZ-NLCs are significantly more efficient in treating and preventing the development of Echinococcus granulosus protoscoleces, metacestodes, and cysts in mice compared to free ABZ. ABZ-NLCs lead to more effective treatment of these parasites.
PARASITOLOGY RESEARCH
(2021)
Article
Parasitology
Juan Pablo Arrabal, Hector Gabriel Avila, Maria Romina Rivero, Federico Camicia, Martin Miguel Salas, Sebastian A. Costa, Carlos G. Nocera, Mara C. Rosenzvit, Laura Kamenetzky
VETERINARY PARASITOLOGY
(2017)
Article
Infectious Diseases
Federico Camicia, Ana M. Celentano, Malcolm E. Johns, John D. Chan, Lucas Maldonado, Hugo Vaca, Nicolas Di Siervi, Laura Kamentezky, Ana M. Gamo, Silvia Ortega-Gutierrez, Mar Martin-Fontecha, Carlos Davio, Jonathan S. Marchant, Mara C. Rosenzvit
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Parasitology
Natalia Macchiaroli, Marcela Cucher, Laura Kamenetzky, Cristian Yones, Leandro Bugnon, Matt Berriman, Peter D. Olson, Mara Cecilia Rosenzvit
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2019)
Article
Infectious Diseases
Gustavo Mourglia-Ettlin, Sebastian Miles, Maria Velasco-De-Andres, Noelia Armiger-Borras, Marcela Cucher, Sylvia Dematteis, Francisco Lozano
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Parasitology
Michaela Herz, Klaus Brehm
PARASITES & VECTORS
(2019)
Article
Parasitology
Jorge L. Porfido, Michaela Herz, Ferenc Kiss, Laura Kamenetzky, Klaus Brehm, Mara C. Rosenzvit, Betina Corsico, Gisela R. Franchini
PARASITOLOGY RESEARCH
(2020)
Article
Infectious Diseases
Matias Gaston Perez, Markus Spiliotis, Natalia Rego, Natalia Macchiaroli, Laura Kamenetzky, Nancy Holroyd, Marcela Alejandra Cucher, Klaus Brehm, Mara Cecilia Rosenzvit
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Review
Parasitology
Javier Sotillo, Mark W. Robinson, Michael J. Kimber, Marcela Cucher, Maria Eugenia Ancarola, Peter Nejsum, Antonio Marcilla, Ramon M. Eichenberger, Lucienne Tritten
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2020)
Article
Parasitology
Michaela Herz, Klaus Brehm
Summary: The study reveals the important role of serotonin in E. multilocularis development and proliferation, with evidence that serotonin is crucial for parasite integrity and survival. Serotonin also stimulates parasite metacestode development and proliferation, potentially contributing to parasite formation and growth in the liver.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Maria Eugenia Ancarola, Gabriel Lichtenstein, Johannes Herbig, Nancy Holroyd, Mara Mariconti, Enrico Brunetti, Matthew Berriman, Krystyna Albrecht, Antonio Marcilla, Mara Cecilia Rosenzvit, Laura Kamenetzky, Klaus Brehm, Marcela Cucher
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Infectious Diseases
Natalia Macchiaroli, Matias Preza, Matias Gaston Perez, Laura Kamenetzky, Marcela Cucher, Uriel Koziol, Estela Castillo, Matthew Berriman, Klaus Brehm, Mara Cecilia Rosenzvit
Summary: The neglected zoonotic disease alveolar echinococcosis (AE) is caused by the metacestode stage of the tapeworm parasite Echinococcus multilocularis. MicroRNAs play important roles in regulating gene expression. The research identified 37 miRNAs in E. multilocularis, some of which are absent in the host. The study also revealed highly regulated miRNAs during different transitions or cultured conditions and showed that miR-71 is expressed in germinative cells and other cell types in E. multilocularis metacestodes.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Marcela A. Cucher, Maria Eugenia Ancarola, Laura Kamenetzky
Summary: In recent years, cell free or extracellular RNAs (ex-RNAs) have emerged as novel intercellular messengers between animal cells, including pathogens. They have been found to play important roles in infectious diseases and have been studied in parasitic helminths. Protected by encapsulation in extracellular vesicles (EV) or association to proteins or lipoproteins, ex-RNAs have been detected in the excretion/secretion products of helminth parasites.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nadja Thielemann, Michaela Herz, Oliver Kurzai, Ronny Martin
Summary: The human body is home to a dynamic ecosystem of millions of microbes, with fungi playing a smaller but significant role. Fungi can be found in various host niches such as the gut, oral cavity, and skin, and have potential impacts on the health and disease of the human host.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Infectious Diseases
Alexander Maximilian Aldejohann, Michaela Herz, Ronny Martin, Grit Walther, Oliver Kurzai
Summary: In Germany, resistant C. glabrata strains are emerging, with overlapping resistance to anidulafungin and fluconazole, and anidulafungin resistance may occur despite a wild-type FKS genotype.
JAC-ANTIMICROBIAL RESISTANCE
(2021)
Article
Biotechnology & Applied Microbiology
Lucas L. Maldonado, Juliana Assis, Flavio M. Gomes Araujo, Anna C. M. Salim, Natalia Macchiaroli, Marcela Cucher, Federico Camicia, Adolfo Fox, Mara Rosenzvit, Guilherme Oliveira, Laura Kamenetzky
