期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 43, 期 7, 页码 515-520出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2013.01.008
关键词
Strongyloides stercoralis; Insulin receptor; Ss-daf-2; DAF-2; Alternate splicing; Dauer
类别
资金
- National Institutes of Health (NIH), USA [AI-50688, RR02512]
- NIH [AI007532]
- NIH National Center for Research Resources
We hypothesise that developmental arrest in infectious larvae of parasitic nematodes is regulated by signalling pathways homologous to Caenorhabditis elegans DAF (dauer formation) pathways. Alignment of Strongyloides stercoralis (Ss) DAF-2 with DAF-2 of C elegans and homologs of other species shows that most structural motifs in these insulin-like receptors are conserved. However, the catalytic domain of Ss-DAF-2 contains two substitutions (Q1242 and Q1256), that would result in constitutive dauer formation in C elegans or diabetes in vertebrate animals. Ss-daf-2 also shows two alternately spliced isoforms, the constitutively expressed Ss-daf-2a, and Ss-daf-2b, which is only expressed in stages leading to parasitism. (C) 2013 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据