期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 42, 期 6, 页码 589-595出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2012.03.008
关键词
Malaria; Mosquito; Vector biology; Plasmodium; COI; Immunity; Complement
类别
资金
- Institut de Recherche pour le Developpement (IRD), France
- DSF-IRD
- Institut National de la Sante et de la Recherche Medicate [Inserm U963]
- Centre National de la Recherche Scientifique [CNRS UPR9022]
- IRD-CNRS [6774.00]
- EC FP7 Network of Excellence
- EC FP7 MALVECBLOK
- Ministry of Culture, Higher Education and Research, CRP-Sante, Luxembourg
Mosquito infections with natural isolates of Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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