期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 40, 期 2, 页码 157-161出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2009.11.010
关键词
Cutaneous leishmaniasis; Murine model; Co-infection; B cells; Macrophages
类别
资金
- National Institutes of Health [K08Al076616, A148357]
- Fort Dodge Animal Health Fellowship in Veterinary Medicine.
Infection of C3HeB/FeJ and C57BL/6 mice with Leishmania major stimulates a healing cell-mediated immune response, while Leishmania amazonensis infection leads to chronic disease. Here we show C3HeB/FeJ mice co-infected with both species of Leishmania heal, while co-infected C57BL/6 mice do not. Using an in vitro killing assay we determined B cells from infected C57BL/6 mice are ineffective in promoting parasite killing compared with B cells from infected C3HeB/FeJ mice. Furthermore, infected C57BL/6 mice produce less antigen-specific antibodies compared with infected C3HeB/FeJ mice. These findings Suggest B cells play a required role in the cell-mediated immune response against L. amazonensis. (C) 2009 Australian Society for Parasitology Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据