期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 39, 期 2, 页码 175-189出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2008.10.001
关键词
Genetic diversity; Apicomplexa; Genotyping; Molecular epidemiology; Population structure
类别
资金
- Wellcome Trust and the European Union [ICA4-2000-300020]
- State Secretariat for Education and Research [CC05.0043]
- Swiss National Science Foundation [3100A0-104043]
- Spanish Ministry of Education and Science [AGL2007-60132/GAN]
- I.N.I.A. [RTA04-047-C2]
Apicomplexan parasites include many parasites of importance either for livestock or as Causative agents of human diseases. The importance of these parasites has been recognised by the European Commission and resulted in support of the COST (Cooperation in Science and Technology) Action 857 'Apicomplexan Biology in the Post-Genomic Era'. In this review we discuss the current understanding in 'Biodiversity and Population Genetics' of the major apicomplexan parasites, namely the Eimeria spp., Cryptosporidium spp., Toxoplasma gondii, Neospora caninum, Theileria spp. and Plasmodium spp. During the past decade molecular tools for characterizing and monitoring parasite populations have been firmly established as an integral part of field studies and intervention trials. Analyses have been conducted for most apicomplexan pathogens to describe the extent of genetic diversity, infection dynamics or population structure. The underlying key question for all parasites is to understand flow genetic diversity influences epidemiology and pathogenicity and its implication in therapeutic and vaccination strategies as well as disease control. Similarities in the basic biology and disease or transmission patterns among this order of parasites promote multifaceted discussions and comparison of epidemiological approaches and methodological tools. This fosters mutual learning and has the potential for cross-fertilisation of ideas and technical approaches. (c) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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